A 3D imaging system integrating photoacoustic and fluorescence orthogonal projections for anatomical, functional and molecular assessment of rodent models

Brecht, Hans-Peter; Ivanov, Vassili; Dumani, Diego S.; Emelianov, Stanislav; Anastasio, Mark A.; Ermilov, Sergey A.

doi:10.1117/12.2290880

Cited by 1 publication

(4 citation statements)

References 27 publications

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“…Volumetric PACT imagers commonly adopt a sequential data acquisition strategy utilizing rotating measurement gantries because of their cost-effectiveness and simplified hardware. 2,[19][20][21] However, the relatively slow data acquisition times associated with this approach pose significant challenges for dynamic imaging. Consequently, previous studies on dynamic PACT have predominantly focused on 2D dynamic imaging scenarios, leveraging the rapid data acquisition and computationally less demanding image reconstruction calculations of 2D systems.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

“…In the context of PACT, the sequential data acquisition strategy commonly involves utilizing one or more rotating or translating ultrasonic transducer arrays within single or multiple acoustic probes. 2,19,20 This approach facilitates data collection by rotating the probes along a fixed axis, resulting in the acquisition of a few tomographic measurements at each step, as depicted in Fig. 1.…”

Section: Imaging Model For Sequential Volumetric Imagers and Inverse ...mentioning

confidence: 99%

“…⊳ Increment outer loop iteration end while 4.1 3D PACT Imaging System Specifications for Experimental and Numerical Studies The TriTom preclinical imaging system 19,51 developed by PhotoSound was employed for the experimental studies and emulated for the numerical in-silico studies. It integrates photoacoustic (PA) and fluorescence (FL) imaging modalities, harnessing their individual strengths.…”

Section: Low-rank Matrix Estimation-based Spatiotemporal Image Recons...mentioning

confidence: 99%

“…They often target two-dimensional (2D) spatial imaging due to shorter data acquisition times and computationally less demanding image reconstruction compared with 3D imaging. 11,[14][15][16][17][18] Most existing 3D PACT imagers developed to date utilize a rotating measurement geometry in which the tomographic data are sequentially acquired 2,[19][20][21] as opposed to being acquired simultaneously at all views. This design is advantageous because it reduces system costs by employing a limited number of acoustic transducers and associated electronics.…”

Section: Introductionmentioning

confidence: 99%

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Spatiotemporal image reconstruction to enable high-frame-rate dynamic photoacoustic tomography with rotating-gantry volumetric imagers

Cam,

Wang,

Thompson

et al. 2024

J. Biomed. Opt.

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Dynamic photoacoustic computed tomography (PACT) is a valuable imaging technique for monitoring physiological processes. However, current dynamic PACT imaging techniques are often limited to two-dimensional spatial imaging. Although volumetric PACT imagers are commercially available, these systems typically employ a rotating measurement gantry in which the tomographic data are sequentially acquired as opposed to being acquired simultaneously at all views. Because the dynamic object varies during the data-acquisition process, the sequential data-acquisition process poses substantial challenges to image reconstruction associated with data incompleteness. The proposed image reconstruction method is highly significant in that it will address these challenges and enable volumetric dynamic PACT imaging with existing preclinical imagers. Aim:The aim of this study is to develop a spatiotemporal image reconstruction (STIR) method for dynamic PACT that can be applied to commercially available volumetric PACT imagers that employ a sequential scanning strategy. The proposed reconstruction method aims to overcome the challenges caused by the limited number of tomographic measurements acquired per frame.Approach: A low-rank matrix estimation-based STIR (LRME-STIR) method is proposed to enable dynamic volumetric PACT. The LRME-STIR method leverages the spatiotemporal redundancies in the dynamic object to accurately reconstruct a four-dimensional (4D) spatiotemporal image. Results:The conducted numerical studies substantiate the LRME-STIR method's efficacy in reconstructing 4D dynamic images from tomographic measurements acquired with a rotating measurement gantry. The experimental study demonstrates the method's ability to faithfully recover the flow of a contrast agent with a frame rate of 10 frames per second, even when only a single tomographic measurement per frame is available. Conclusions:The proposed LRME-STIR method offers a promising solution to the challenges faced by enabling 4D dynamic imaging using commercially available volumetric PACT imagers. By enabling accurate STIRs, this method has the potential to significantly advance preclinical research and facilitate the monitoring of critical physiological biomarkers.

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Section: Conclusion and Discussionmentioning

confidence: 99%

Section: Imaging Model For Sequential Volumetric Imagers and Inverse ...mentioning

confidence: 99%

Section: Low-rank Matrix Estimation-based Spatiotemporal Image Recons...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spatiotemporal image reconstruction to enable high-frame-rate dynamic photoacoustic tomography with rotating-gantry volumetric imagers

Cam,

Wang,

Thompson

et al. 2024

J. Biomed. Opt.

Self Cite

View full text Add to dashboard Cite

show abstract

A 3D imaging system integrating photoacoustic and fluorescence orthogonal projections for anatomical, functional and molecular assessment of rodent models

Cited by 1 publication

References 27 publications

Spatiotemporal image reconstruction to enable high-frame-rate dynamic photoacoustic tomography with rotating-gantry volumetric imagers

Spatiotemporal image reconstruction to enable high-frame-rate dynamic photoacoustic tomography with rotating-gantry volumetric imagers

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