A 3D co-culture intestinal organoid system for exploring glucose metabolism

Jianping, Nie; Liao, Wei; Zhang, Zijie; Zhang, Minjiao; Wen, Yuxi; Çapanoğlu, Esra; Sarker, Md. Moklesur Rahman; Zhu, Ruiyu; Zhao, Chao

doi:10.1016/j.crfs.2022.11.021

Cited by 3 publications

(1 citation statement)

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“…If microorganisms and animal cells are used, one might first imagine the interaction between humans and intestinal bacteria. Indeed, several examples of co-culture of human cells and intestinal bacteria have been reported, and the changes in gene expression on the host side during such co-culture experiments have been well studied [ 117 – 118 ]. On the other hand, unlike intestinal bacteria, pathogenic microorganisms that adversely affect human health also interact with host cells when they invade the body [ 119 – 120 ].…”

Section: Reviewmentioning

confidence: 99%

Methodology for awakening the potential secondary metabolic capacity in actinomycetes

Saito,

Arai

2024

Beilstein J. Org. Chem.

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Secondary metabolites produced by actinomycete strains undoubtedly have great potential for use in applied research areas such as drug discovery. However, it is becoming difficult to obtain novel compounds because of repeated isolation around the world. Therefore, a new strategy for discovering novel secondary metabolites is needed. Many researchers believe that actinomycetes have as yet unanalyzed secondary metabolic activities, and the associated undiscovered secondary metabolite biosynthesis genes are called “silent” genes. This review outlines several approaches to further activate the metabolic potential of actinomycetes.

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