A 3D analysis of hindlimb motion during treadmill locomotion in rats after a 14-day episode of simulated microgravity

Canu, Marie‐Hélène; Garnier, Cyril; Lepoutre, F.; Falempin, Maurice

doi:10.1016/j.bbr.2004.07.009

Cited by 39 publications

(34 citation statements)

References 38 publications

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“…Their coordination produced a distorted "8" shaped pattern with a prominent double peak pattern of ankle. This pattern was previously reported in rats [28,32,33]. At the level of interlimb coordination, the ankle and elbow showed a succession of flexion and extension during swing and stance.…”

Section: Intralimb Coordinationsupporting

confidence: 61%

“…An over extended ankle at take off, but more flexed in the main part of the step cycle was also reported in adult suspended rats [28,42]. The ankle extension of suspended rats can be related to changes of paw pressure and muscles spindle stimulation [28,42]. This involves therefore a different mechanism than the one we observed on centrifuged mice.…”

Section: Effects Of Hypergravitymentioning

confidence: 55%

“…They were supposed to show an extensor bias because they constantly adopt a position with the hindlimb extended during their suspension. An over extended ankle at take off, but more flexed in the main part of the step cycle was also reported in adult suspended rats [28,42]. The ankle extension of suspended rats can be related to changes of paw pressure and muscles spindle stimulation [28,42].…”

Section: Effects Of Hypergravitymentioning

confidence: 92%

“…The characterization of the gait, and the basics steps used in gait analysis are largely described in various papers [23,25,[28][29][30]. The kinematic parameters were measured on the right legs.…”

Section: Gait Analysismentioning

confidence: 99%

See 3 more Smart Citations

Kinematics of treadmill locomotion in mice raised in hypergravity

Bojados

Herbin

Jamon

2013

Behavioural Brain Research

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Section: Intralimb Coordinationsupporting

confidence: 61%

Section: Effects Of Hypergravitymentioning

confidence: 55%

Section: Effects Of Hypergravitymentioning

confidence: 92%

Section: Gait Analysismentioning

confidence: 99%

See 2 more Smart Citations

Kinematics of treadmill locomotion in mice raised in hypergravity

Bojados

Herbin

Jamon

2013

Behavioural Brain Research

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“…2) of the wear test was determined according to the tibia load during normal locomotion. The equilibrium knee flexion angle was set to 70 degree [12] and the swing angle was set to 40 degree [13,14]. The frequency was set to 2 Hz (actual 1.86-1.90 Hz, limited by the servo) [15].…”

Section: Wear Test Device and Test Protocolmentioning

confidence: 99%

The collagen microstructural changes of rat menisci and tibiofemoral cartilages under the influence of mechanical loading: An in vitro wear test of whole joints

Cai

Hao

Xiao

et al. 2017

THC

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Abstract. BACKGROUND: Knee osteoarthritis (OA) is suggested to be induced by multi-factors, and mechanical environment is regarded as a risky factor. OBJECTIVE: To investigate the effect of isolated mechanical factor on cartilage. METHODS: An active wear test system was designed to perform parameters-controlled in vitro wear tests on rat knee joints with specific load magnitude, flexion-extension angle, and movement frequency. Six hind limbs of 9-month-old male SpragueDawley rats, with an additional spring on the medial side, were worn by using the custom-designed apparatus. Researchers observed both the menisci and tibial cartilages of these hind limbs using multiphoton laser scanning microscopy to analyze the change of the collagen microstructure caused by wear. RESULTS: Collagen microstructure of both the medial and lateral meniscus became disordered under cyclic load. Some tissues on the surface of the medial tibial cartilage were removed and the middle layer of the medial compartment displayed cracks. On the contrary, the lateral tibial cartilage was intact. CONCLUSIONS: The results implied that cyclic load caused menisci microstructure disarrangement prior to tibial cartilage damage and the collagen structure of mid-layer tibial cartilage failed before that of the superficial layer under the kinematics adopted in the study.

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Scientific rotoscoping: a morphology‐based method of 3‐D motion analysis and visualization

et al. 2010

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Three-dimensional skeletal movement is often impossible to accurately quantify from external markers. X-ray imaging more directly visualizes moving bones, but extracting 3-D kinematic data is notoriously difficult from a single perspective. Stereophotogrammetry is extremely powerful if bi-planar fluoroscopy is available, yet implantation of three radio-opaque markers in each segment of interest may be impractical. Herein we introduce scientific rotoscoping (SR), a new method of motion analysis that uses articulated bone models to simultaneously animate and quantify moving skeletons without markers. The three-step process is described using examples from our work on pigeon flight and alligator walking. First, the experimental scene is reconstructed in 3-D using commercial animation software so that frames of undistorted fluoroscopic and standard video can be viewed in their correct spatial context through calibrated virtual cameras. Second, polygonal models of relevant bones are created from CT or laser scans and rearticulated into a hierarchical marionette controlled by virtual joints. Third, the marionette is registered to video images by adjusting each of its degrees of freedom over a sequence of frames. SR outputs high-resolution 3-D kinematic data for multiple, unmarked bones and anatomically accurate animations that can be rendered from any perspective. Rather than generating moving stick figures abstracted from the coordinates of independent surface points, SR is a morphology-based method of motion analysis deeply rooted in osteological and arthrological data.

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A 3D analysis of hindlimb motion during treadmill locomotion in rats after a 14-day episode of simulated microgravity

Cited by 39 publications

References 38 publications

Kinematics of treadmill locomotion in mice raised in hypergravity

Kinematics of treadmill locomotion in mice raised in hypergravity

The collagen microstructural changes of rat menisci and tibiofemoral cartilages under the influence of mechanical loading: An in vitro wear test of whole joints

Scientific rotoscoping: a morphology‐based method of 3‐D motion analysis and visualization

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