A 3D analysis of growth trajectory and integration during early human prenatal facial growth

Katsube, Motoki; Yamada, Shigehito; Utsunomiya, Noriaki; Yamaguchi, Yasushi; Takakuwa, Tetsuya; Yamamoto, Akira; Imai, Hirohiko; Saito, Atsushi; Vora, Siddharth R.; Morimoto, Naoki

doi:10.1038/s41598-021-85543-5

Cited by 8 publications

(14 citation statements)

References 52 publications

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“…The 3D imaging techniques which can be applied to embryos are CT and MRI. MRI is a favorable device for human fetal samples, as used in previous studies 32 – 35 . However, a spatial resolution of 40 µm is provided by 7 Tesla MRI, which is not minute enough to observe individual embryonic organs.…”

Section: Introductionmentioning

confidence: 99%

The first 3D analysis of the sphenoid morphogenesis during the human embryonic period

Utsunomiya

Katsube

Yamaguchi

et al. 2022

Sci Rep

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The sphenoid has a complicated shape, and its morphogenesis during early development remains unknown. We aimed to elucidate the detailed morphogenesis of the sphenoid and to visualize it three-dimensionally using histological section (HS) and phase-contrast X-ray CT (PCX-CT). We examined 54 specimens using HS and 57 specimens using PCX-CT, and summarized the initial morphogenesis of the sphenoid during Carnegie stage (CS) 17 to 23. The 3D models reconstructed using PCX-CT demonstrated that some neural foramina have the common process of "neuro-advanced" formation and revealed that shape change in the anterior sphenoid lasts longer than that of the posterior sphenoid, implying that the anterior sphenoid may have plasticity to produce morphological variations in the human face. Moreover, we measured the cranial base angle (CBA) in an accurate midsagittal section acquired using PCX-CT and found that the CBA against CS was largest at CS21. Meanwhile, CBA against body length showed no striking peak, suggesting that the angulation during the embryonic period may be related to any developmental events along the progress of stages rather than to a simple body enlargement. Our study elucidated the normal growth of the embryonic sphenoid, which has implications for the development and evolution of the human cranium.

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Section: Introductionmentioning

confidence: 99%

The first 3D analysis of the sphenoid morphogenesis during the human embryonic period

Utsunomiya

Katsube

Yamaguchi

et al. 2022

Sci Rep

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“…Either types of data can be used in GM [10][11][12] and the latter is often used for the visualization of GM results. [13][14][15][16] Surface data represent "data on the object's surface," and are constructed as polygons. Surface data can be created by regional segmentation from volumetric data by stacking contours extracted from…”

Section: Preparation Of Image Datamentioning

confidence: 99%

“…Red arrows indicate relative outward and forward growth, while blue arrows indicate relative inward in backward growth in specific areas of the fetal skull. Reprinted with permission from Katsube et al 15 grown", [30][31][32] which is important for the pathogenesis of congenital facial anomalies. Cartilages in the cranial base or nasal septum have played an important role in facial development.…”

Section: Integration Among Organsmentioning

confidence: 99%

“…Coquerelle et al 13 investigated middle and lower facial growth using 20 human fetuses ranging from 10 to 34 weeks of gestation and obtained a nonlinear growth trajectory with two transitional periods at 16 and 25 weeks of gestation. Katsube et al 15 calculated the average growth curve of the facial skeleton after correction of mouth‐open position by applying weighted average analysis (Nadaraya–Watson kernel regression) 27–29 using 49 human fetuses with CRLs of 29.8–225 mm and reported that the trajectory had three transitional periods at 11.3, 13.4, and 15.7 weeks of gestation (Figure 4). The difference in the transitional periods may be due to the correction of the mouth‐open position in the latter study and differences in the number of specimens used and the study population.…”

Section: Facial Development In Human Embryos and Fetusesmentioning

confidence: 99%

“…The volume data contain all information, including the inside of the objects, while the surface data contain only surface information, thus having less data. Either types of data can be used in GM 10–12 and the latter is often used for the visualization of GM results 13–16 …”

Section: Introduction To Gmmentioning

confidence: 99%

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Application of geometric morphometrics for facial congenital anomaly studies

Katsube

Yamada

Utsunomiya

et al. 2022

Congenital Anomalies

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The face is a small complex three-dimensional (3D) structure composed of various bones and essential organs. Congenital anomalies of those organs represent various deformities; therefore, their quantification has been challenging. Linear measurements, such as lengths or angles between landmarks, called conventional morphometrics, have been used to quantify their phenotypes usually using 2D images, such as photographs or X-ray images. During analysis, geometric information, which refers to the relative position of each structure, is lost. Geometric morphometrics (GM) uses shape configurations, including anatomical landmarks, which can retain

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The role of the nasal region in craniofacial growth: An investigation using path analysis

Landi

Barraclough

Evteev

et al. 2021

The Anatomical Record

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This study focuses on the role of the nasal region and its interactions with adjacent facial elements during early ontogeny. A series of linear measurements, areas and volumes were extracted from a collection of 227 medical CTscans of children from 0 to 6 years of age. These measurements describe aspects of the form of the orbit, maxilla, peri-alveolar (subnasal) region, nasal area, eye, oral region, masseter, and temporal muscles. Hypothesized interactions were then examined using path analysis. Two paths were designed: the first to investigate potential interactions in, and relative contributions of the nasal derivatives and adjacent regions to overall facial growth and development; the second path sees the addition of facial soft tissue measurements and aims to assess their effects on skeletal components, and on overall facial growth and development. The results of the first path indicate a large contribution of the nasal and subnasal regions to facial development. This indicates that the nasal septum and the developing dentition provide an important but variable contribution to facial ontogeny during early years. This result is confirmed in the second path, where the soft tissue elements were added to the diagram. Results of the second path indicate that the soft tissues contribute only locally to the development of some skeletal elements of the face. This indicates that the contribution of skeletal components has a more direct effect on facial height than soft tissue matrices, however there are complex interactions between soft tissues and skeletal elements throughout ontogeny.

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A 3D analysis of growth trajectory and integration during early human prenatal facial growth

Cited by 8 publications

References 52 publications

The first 3D analysis of the sphenoid morphogenesis during the human embryonic period

The first 3D analysis of the sphenoid morphogenesis during the human embryonic period

Application of geometric morphometrics for facial congenital anomaly studies

The role of the nasal region in craniofacial growth: An investigation using path analysis

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