A 37XO chromosome complement in a kitten

Long, Susan E.; Berepubo, N. A.

doi:10.1111/j.1748-5827.1980.tb01366.x

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…The first case of X monosomy in a kitten with coarctation of the aorta was presented by Norby et al (1974). In the second case, a single cell line (37,X) was identified in a cat with spina bifida, but this malformation was not related with the X monosomy (Long and Berepubo 1980). The third case it was a small Burmese cat with primary anestrus and ovaries containing inactive germinal epithelium only (Johnston et al 1983).…”

Section: Introductionmentioning

confidence: 99%

X monosomy in a Virilized Female Cat

Szczerbal

Niżański

Dzimira

et al. 2015

Reprod Domestic Animals

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An infertile Siamese female cat was subjected for clinical, histological, cytogenetic and molecular studies due to ambiguous external genitalia (vulva, vagina, rudimentary penis and scrotum-like structure) and masculine behaviour. An elevated oestrogen activity and a detectable level of testosterone were found. The cat underwent laparotomy. The gonads and the uterus were removed and subjected for histological studies, which showed ovaries with corpora lutea and a some primordial follicles. Chromosome studies of lymphocyte and fibroblast cultures, with the use of Giemsa staining, G-banding and whole X chromosome painting by fluorescence in situ hybridization, revealed pure X monosomy. Molecular analysis showed the absence of the SRY gene. Our study revealed for the first time that X monosomy in cats may be associated with virilization, in spite of the lack of the SRY gene.

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Section: Introductionmentioning

confidence: 99%

X monosomy in a Virilized Female Cat

Szczerbal

Niżański

Dzimira

et al. 2015

Reprod Domestic Animals

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“…Three cases of feline 37,X have been reported, 2 of which died by 3 days of age [Norby et al, 1974;Long and Berepubo, 1980]. Normal ovarian histology was reported in one of these [Norby et al, 1974].…”

Section: Monosomy X and Variantsmentioning

confidence: 99%

Gonadal and Sex Differentiation Abnormalities of Dogs and Cats

Meyers-Wallen¹

2011

Sex Dev

105

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The molecular steps in normal sexual development were largely discovered by studying patients and animal models with disorders of sexual development (DSD). Although several types of DSD have been reported in the cat and dog, which are often strikingly similar to human DSD, these have been infrequently utilized to contribute to our knowledge of mammalian sexual development. Canine and feline cases of DSD with sufficient evidence to be considered as potential models are summarized in this report. The consensus DSD terminology, and reference to previous terminology, is used to foster adoption of a common nomenclature that will facilitate communication and collaboration between veterinarians, physicians, and researchers. To efficiently utilize these unique resources as molecular tools continue to improve, it will be helpful to deposit samples from valuable cases into repositories where they are available to contribute to our understanding of sexual development, and thus improve human and animal health.

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“…Phenotypic male cats with a 39,XXY karyotype or its mosaic variants 38,XY/39,XXY and 38,XY/39,XYY [Centerwall and Benirschke, 1975;Moran et al, 1984;Leaman et al, 1999;Schmidt-Küntzel et al, 2009;Pedersen et al, 2014] as well as tomcats with 38,XX/38,XY chimeric karyotypes [Centerwall and Benirschke, 1975;Moran et al, 1984;Leaman et al, 1999;Long, 1999] may only be found if they have unusual tortoiseshell or calico coats. Cats with monosomy X and variants as well as XXX and variants are phenotypic fe-males [Norby et al, 1974;Long and Berepubo, 1980;Johnston et al, 1983;Manna and Sarkar, 1988]. Pregnancy and unilateral ovarian dysgenesis were reported in 2 queens with the mosaic karyotypes 37,X/38,XX and 37,X/39,XXX [Dybdahl Thomsen et al, 1987].…”

Section: X/38xy Mosaicism In a Cryptorchidmentioning

confidence: 99%

37,X/38,XY Mosaicism in a Cryptorchid Bengal Cat with Müllerian Duct Remnants

Balogh¹,

Berger²,

Pieńkowska-Schelling

et al. 2015

Sex Dev

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A 23-month-old tomcat was referred to our clinic because of male behavioral problems, cryptorchidism, and an undefined intra-abdominal organ resembling a uterus. Ultrasonography and computed tomography showed 2 fluid-filled tubular structures dorsolaterally to the bladder and connected to the pelvic urethra. The cat was castrated, and the tubular structures were surgically removed. Histology identified them as Müllerian duct remnants. The testes were hypoplastic, the epididymes and deferent ducts were normal. Cytogenetic analyses revealed the presence of a mosaic 37,X/38,XY karyotype which explains the clinical findings.

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A 37XO chromosome complement in a kitten

Cited by 10 publications

References 13 publications

X monosomy in a Virilized Female Cat

X monosomy in a Virilized Female Cat

Gonadal and Sex Differentiation Abnormalities of Dogs and Cats

37,X/38,XY Mosaicism in a Cryptorchid Bengal Cat with Müllerian Duct Remnants

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