A 31-bp Indel in the 5' UTR region of the GNB1L gene is significantly associated with body weight and carcass traits in chickens

Abstract

Background G-protein subunit beta 1 like (GNB1L) can encode a G-protein beta-subunit-like polypeptide, the chicken GNB1L gene is up-regulated in the breast muscle of high-feed efficiency chickens, and its expression is 1.52-fold that of low-feed efficiency chickens. However, there are no reports describing the effects of GNB1L gene Indel on the growth and carcass traits of chickens. Results This study identified a 31-bp Indel in 5' UTR of the GNB1L gene and elucidated the effect of this gene mutation on the growth and carcass traits in chickens. The results indicated that the 31-bp Indel was highly significant associations with body weight at 8 different stages, and also significantly correlated with daily gain of 0 to 4 weeks and 4 to 8 weeks. Similarly, the mutation was significantly associated with small intestine length, breast width, breast deep and breast muscle weight in carcass traits. Moreover, DD and ID are inferior genotypes for the growth and carcass traits of chickens. Conclusions In a word, these findings suggest that the 31-bp Indel of GNB1L gene is significantly affected body weight and carcass traits in chickens, and can serve as a potential molecular marker for chicken genetics and breeding programs.