2006
DOI: 10.1016/j.jaci.2006.01.023
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A 3-year Course of Subcutaneous Specific Immunotherapy Results in Long-term Prevention of Asthma in Children. Ten Year Follow-up on the PAT-Study

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Cited by 9 publications
(11 citation statements)
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“…At the 10-year follow-up (7 years after discontinuing immunotherapy) the children in the immunotherapy group had significantly less asthma compared with the control group: 16 out of 48 with asthma in the immunotherapy group compared with 24/29 of the untreated control group (OR = 2.48 [1.1-5.4]) in favor of immunotherapy for prevention of asthma (FIGURE 1) [40]. The authors concluded that immunotherapy for 3 years with standardized allergen extracts of grass and/or birch results in a long-term preventive effect on the development of asthma in children with only seasonal rhinoconjunctivitis.…”
Section: Prevention Of the Development Of Asthmamentioning
confidence: 99%
See 1 more Smart Citation
“…At the 10-year follow-up (7 years after discontinuing immunotherapy) the children in the immunotherapy group had significantly less asthma compared with the control group: 16 out of 48 with asthma in the immunotherapy group compared with 24/29 of the untreated control group (OR = 2.48 [1.1-5.4]) in favor of immunotherapy for prevention of asthma (FIGURE 1) [40]. The authors concluded that immunotherapy for 3 years with standardized allergen extracts of grass and/or birch results in a long-term preventive effect on the development of asthma in children with only seasonal rhinoconjunctivitis.…”
Section: Prevention Of the Development Of Asthmamentioning
confidence: 99%
“…Local reactions are fairly common, with a frequency ranging from 26 to 86% of [39,40]. (B) Retrospective study of 436 nonasthmatic adults: 332 subjects with allergic rhinitis and 104 with no allergic rhinitis or history of atopy at the beginning of the study found that treatment with SCIT was significantly and inversely related to the development of new onset asthma (OR: 0.53; 95% CI: 0.32-0.86) [41].…”
Section: Local Reactionsmentioning
confidence: 99%
“…In the treated group, 19% developed asthma compared with 32% in the untreated group and 60% of the treated group had no asthma compared with 40% of the untreated group. Recently, additional data 22 were presented indicating that preventing the march to asthma continued to persist as long as 10 years after discontinuing immunotherapy (Fig. 4).…”
Section: Long-term Effectsmentioning
confidence: 97%
“…Several studies have documented a sustained effect of SIT up to 7 years after ending treatment [11][12][13][14] . Based on this evidence a time horizon of 9 years with a cycle length of 1 year was chosen; the grass pollen season had a length of 3 months 17 .…”
Section: Model Structurementioning
confidence: 99%
“…Effects of immunotherapy in terms of symptom scores and SFDs observed after one season were assumed to remain constant and thus extrapolated up to 9 years, based on current results from grass allergen SIT [11][12][13][14] . Patients discontinuing immunotherapy generate costs and outcomes associated with the symptomatic treatment arm.…”
Section: Effect Parametersmentioning
confidence: 99%