A 3-Year Causative Study of Pompholyx in 120 Patients

Guillet, Marie Hélène; Wierzbicka, E.; Guillet, S.; Dagrégorio, G.; Guillet, G.

doi:10.1001/archderm.143.12.1504

Cited by 60 publications

(53 citation statements)

References 28 publications

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“…RXR motif search was conducted using fuzznuc program in EMBOSS package for the pattern of 5′-RGKTCAN(1,5)RGKTCAN-3′.…”

Section: Methodsmentioning

confidence: 99%

“…Pompholyx, or dyshidrotic eczema, is a chronic vesicobullous disorder of the palms and solest characterized by many deep-seated pruritic, painful, clear vesicles (1) (Figure 1A). The small vesicles can fuse and may then create scaling and painful fissures which ultimately incapacitate the patient for work and activities of daily living.…”

Section: Introductionmentioning

confidence: 99%

“…Many factors are suspected to trigger pompholyx, including allergens, stress or seasonal changes but the exact immunological mechanism(s) remains elusive. The condition has been associated with allergies to metals, foods or drugs or left undiagnosed as “idiopathic” (1, 2). Importantly, the factors that maintain the disease once it has become chronic are even more elusive.…”

Section: Introductionmentioning

confidence: 99%

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The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx

Soler¹,

Bai²,

Ortega³

et al. 2015

Medical Hypotheses

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Pompholyx remains a chronic skin affliction without a compelling pathophysiological explanation. The disease is characterized by the sudden onset of vesicles exclusively in the palms and soles which generally resolves. However, the disease may progress and the vesicles may expand and fuse; with chronicity there is deep fissuring. Multiple therapeutic approaches are available, but the disease is often resistant to conventional treatments. Currently, oral alitretinoin is used for patients with resistant chronic disease; however, this therapy is only approved for use in the UK, Europe and Canada. In this paper we wish to put forward a hypothesis: exposure to water and the subsequent steep osmotic gradient imbalance are key factors driving skin dehydration seen in pompholyx patients once the disease becomes chronic. The mechanistic explanation for the epidermal fissuring might lie in the over-expression across the mid and upper epidermis, including the stratum corneum, of two water/glycerol channel proteins aquaporin 3 and aquaporin 10, expressed in the keratinocytes of afflicted pompholyx patients. The over-expression of these two aquaporins may bridge the abundantly hydrated dermis and basal epidermis to the outer environment allowing cutaneous water and glycerol to flow outward. The beneficial effects reported in alitretinoin-treated patients with chronic hand eczemas may be due potential regulation of aquaporin 3 and aquaporin 10 by alitretinoin.

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“…RXR motif search was conducted using fuzznuc program in EMBOSS package for the pattern of 5′-RGKTCAN(1,5)RGKTCAN-3′.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx

Soler¹,

Bai²,

Ortega³

et al. 2015

Medical Hypotheses

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“…Nickel is known to be a common cause of contact allergies, and it is present in various metal compounds, such as coins, ornaments, utensils and dental braces. Systemic intake of nickel can induce pompholyx and/or systemic contact dermatitis (9,10). However, we are not aware of any prior reports of papuloerythrodermalike eruption as a systemic symptom.…”

Section: Discussionmentioning

confidence: 92%

Systemic Nickel Allergy Presenting as Papuloerythroderma-like Eruptions

Kato¹,

Satoh²,

Tanaka³

et al. 2010

Acta Derm Venerol

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Letters to the Editor 655 328-332. 4. Rogawski MA, Loscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat Med 2004; 10: 685-692. 5. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, et al. Impaired nociception and pain sensation in mice lacking the capsaiein receptor. Science 2000:288:306-313. 6. Hölzer P. Capsaiein: cellular targets, mechanisms of action. and selectivity for thin sensory neurons. Pharmacol Rev 1991; 43: 143-201. 7. Senba E, Katanosaka K, Yajima H, Mizumura K. The immunosuppressant FK506 activates capsaiein-and bradykinin-sensitive DRG neurons and cutaneous C-fibers.Papuloerythroderma is characterized by erythroderma with widespread coalescent solid or lichenoid papules, and eruptions often spare skin folds. Below is reported an old women experiencing pmntic pupules for a long period.CASE REPORT An 82-year-old woman had had pruritic papules on her entire body for 4 years. Her medical history included hypertension eontrolled with cilnidipine. On examination, there were numerous red-brown lichenoid papules on her trunk and extremities. The papules tended to aggregate or coalesce to form diffuse erythematous plaques with sparing flexors, mimicking papuloerythroderma (Fig. 1 ). Laboratory data revealed elevated levels of blood eosinophils (1204/(il) and lactate dehydrogenase (354 U/1), but no other abnormal findings. Histologically, lichenoid papules showed irregular acanthosis with hyperkeratosis. There was a cellular inftltrate comprising lymphocytes and eosinophils in the upper dermis (Fig. 2). Extensive examinations, including serum tumour markers, eomputed tomography and fiberscope Fig. I Clinical features of skin lesions. (A) Numerous lichenoid papules were dislributed on the trunk. (B) Eruptions spared popliteal fossa.Fig. 2. Clinical and histological manifestations of lichenoid papules. (A) Polygonal, red, solid papules on the arms. (B) Papules showed parakeratotic hyperkeratosis and aeanthosis with dermal cellular infiltrates. (Haematoxylin and eosin staining, original magnification x 100).examination of the gastrointestinal tract, did not reveal any evidence of internal malignancy. The condition had been resistant to topical corticosteroids prior to adtnission, but the skin lesions improved after external application of petrolatum and without cessation of cilnidipine. Lymphocyte stimulation test and patch-testing for cilnidipine (10% and 20% in petrolatum) were negative. She did not have a history of allergic reactions to metals. However, patch-testing for metals revealed positive Acta Derm Venereol 90

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“…Differential diagnoses include pustular psoriasis, bullous pemphigoid and contact dermatitis 1. The exact causal mechanism is unknown although contact dermatitis and concurrent mycoses have been implicated in the pathogenesis of some cases 2. Topical and systemic corticosteroids are the mainstay of treatment but there are reports of cases that have been treated with botulinum toxin and calcineurin inhibitors 3…”

Section: Descriptionmentioning

confidence: 99%

Vesico-bullous rash caused by pompholyx eczema

Charlton

2012

Case Reports

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DESCRIPTIONA 31-year-old man presented to dermatology with a 4 day history of an intensely itchy, linear, vesicular rash affecting the palms of both hands, on the background of recent exposure to a patient with scabies. The patient had a history of childhood eczema and asthma but no exacerbations in adulthood. Examination and microscopy revealed a vesicular rash with an absence of any burrows, mites or eggs. A provisional diagnosis of pompholyx eczema was made and the patient was commenced on mild topical corticosteroids. The patient re-presented 5 days later with worsening symptoms and a severe vesico-bullous rash ( fi gure 1 ) and was commenced on oral prednisolone and high strength topical corticosteroids. Symptoms initially continued to progress for 2 further days with enlarging of the bullae ( fi gure 2 ). The image demonstrates the coalescence of vesicles to form tense bullae adjacent to areas of multiple vesicles ( fi gure 3 ).

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A 3-Year Causative Study of Pompholyx in 120 Patients

Cited by 60 publications

References 28 publications

The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx

The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx

Systemic Nickel Allergy Presenting as Papuloerythroderma-like Eruptions

Vesico-bullous rash caused by pompholyx eczema

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