A 3′-tRNA-derived fragment enhances cell proliferation, migration and invasion in gastric cancer by targeting FBXO47

Zhang, Fei; Shi, Jinxin; Wu, Zhonghua; Gao, Peng; Zhang, Weixu; Qu, Bicheng; Wang, Xin; Song, Yongxi; Wang, Zhenning

doi:10.1016/j.abb.2020.108467

Cited by 49 publications

(54 citation statements)

References 55 publications

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“…Importantly, the elevated level of 3-tRF Leu TAA significantly decreases the expression of target genes in vivo in HEK293T cells (Kuscu et al, 2018). A recent study found that 3-tRF Ala AGC interacts with Ago2 to modulate the expression of tumor suppressor FBZO47 by binding to 3 UTR, resulting in enhanced cell proliferation, migration and invasion in gastric cancer (Zhang et al, 2020). Altogether, accumulating evidence suggests that tsRNAs are capable of repressing target genes posttranscriptionally through binding to Ago proteins, similar to miRNAs.…”

Section: Generation Of Trna Fragments Serves Regulatory Roles In Vivomentioning

confidence: 97%

Hijacking tRNAs From Translation: Regulatory Functions of tRNAs in Mammalian Cell Physiology

Avcilar-Kucukgoze

Kashina

2020

Front. Mol. Biosci.

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Transfer tRNAs (tRNAs) are small non-coding RNAs that are highly conserved in all kingdoms of life. Originally discovered as the molecules that deliver amino acids to the growing polypeptide chain during protein synthesis, tRNAs have been believed for a long time to play exclusive role in translation. However, recent studies have identified key roles for tRNAs and tRNA-derived small RNAs in multiple other processes, including regulation of transcription and translation, posttranslational modifications, stress response, and disease. These emerging roles suggest that tRNAs may be central players in the complex machinery of biological regulatory pathways. Here we overview these non-canonical roles of tRNA in normal physiology and disease, focusing largely on eukaryotic and mammalian systems.

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Section: Generation Of Trna Fragments Serves Regulatory Roles In Vivomentioning

confidence: 97%

Hijacking tRNAs From Translation: Regulatory Functions of tRNAs in Mammalian Cell Physiology

Avcilar-Kucukgoze

Kashina

2020

Front. Mol. Biosci.

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“…Although the diagnostic potential of tRF‐3019a is not ideal, it is still better than the previously reported values of CEA (AUC = 0.583) and CA199 (AUC = 0.585). TRF‐3019a can be used as a suitable biomarker for (GC) diagnosis of gastric cancer 41 . Dong et al found that the ROC curve AUC of tRF‐24‐V29K9UV3 IU expression level was 0.…”

Section: Discussionmentioning

confidence: 99%

Low expression of tRF‐Pro‐CGG predicts poor prognosis in pancreatic ductal adenocarcinoma

Gao

et al. 2021

Clinical Laboratory Analysis

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Background & Aims tRFs (tRNA‐derived RNA fragments) have been reported to facilitate cancer progression in multiple cancers. However, their role in pancreatic ductal adenocarcinoma (PDAC) remains to be determined. In this study, we mainly investigated the expression of tRF‐Pro‐CGG in pancreatic ductal adenocarcinoma and evaluated its relationship with the clinicopathology and survival time of patients. Methods 37 cases of pancreatic ductal adenocarcinoma, and 15 cases of normal pancreatic tissues were collected which were resected by surgery from January 2017 to June 2020 from the Department of Hepatobiliary and Pancreatic surgery of Changzhou second people's Hospital. The expression of tRF‐Pro‐CGG in paraffin‐embedded tissues was detected by fluorescence in situ hybridization (FISH). The clinical data including age, sex, tumor location, tumor diameter, tumor clinical stage (TNM stage), depth of invasion, regional lymph node metastasis, serum CA199, and serum CEA were collected and analyzed retrospectively, whether the expression tRF‐Pro‐CGG was correlation with the pathological parameters and clinical outcomes of patients. Results The expression level of tRF‐Pro‐CGG was significantly downregulated in PDAC and associated with an advanced TNM stage (P=0.000) and the N stage (P=0.000) of patients. More importantly, low tRF‐Pro‐CGG expression predicted poor survival in PDAC patients (P=0.003). Conclusions TRF‐Pro‐CGG is under‐expressed in PDAC and is associated with short clinical survival and poor prognosis. tRF‐Pro‐CGG is an independent prognostic factor, which highlights its role as a potential biomarker for PDAC progression and therapy.

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“…Recently, the role of tRFs in cancer development has attracted wide research attention. An increasing number of studies have highlighted the ability of tRFs to exert both oncogenic [17,47,48] and tumor suppressor functions [27,28,49,50]. In the first studies of the role of tRFs in cancer progression, tRF-1001 (3 -tRF of tRNA SerTGA ) was correlated with increased cell proliferation, while tRF-1001 knockdown resulted in cell cycle arrest and accumulation of tumor cells in the G2 phase in prostate cancer cells [17].…”

Section: Discussionmentioning

confidence: 99%

“…In the first studies of the role of tRFs in cancer progression, tRF-1001 (3 -tRF of tRNA SerTGA ) was correlated with increased cell proliferation, while tRF-1001 knockdown resulted in cell cycle arrest and accumulation of tumor cells in the G2 phase in prostate cancer cells [17]. Furthermore, tRF-3019a (3 -tRF of tRNA AlaAGC ) upregulation was reported to facilitate cell proliferation and invasion in gastric cancer by targeting FBXO47 [47], while 5 -tRF-LeuCAG promoted both cell proliferation and cell cycle progression in non-small cell lung cancer through AURKA downregulation [48]. On the contrary, Goodarzi et al highlighted that endogenous tRFs suppress breast cancer progression via displacement of YBX1 [27], while the CU1276 (3 -tRF of from tRNA GlyGCC ), which is significantly downregulated in lymphoma cell lines, was documented to suppress lymphoma cells' proliferation [28].…”

Section: Discussionmentioning

confidence: 99%

tRNA-Derived Fragments (tRFs) in Bladder Cancer: Increased 5′-tRF-LysCTT Results in Disease Early Progression and Patients’ Poor Treatment Outcome

Papadimitriou

Avgeris

Levis

et al. 2020

Cancers

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The heterogeneity of bladder cancer (BlCa) prognosis and treatment outcome requires the elucidation of tumors’ molecular background towards personalized patients’ management. tRNA-derived fragments (tRFs), although originally considered as degradation debris, represent a novel class of powerful regulatory non-coding RNAs. In silico analysis of the TCGA-BLCA project highlighted 5′-tRF-LysCTT to be significantly deregulated in bladder tumors, and 5′-tRF-LysCTT levels were further quantified in our screening cohort of 230 BlCa patients. Recurrence and progression for non-muscle invasive (NMIBC) patients, as well as progression and patient’s death for muscle-invasive (MIBC) patients, were used as clinical endpoint events. TCGA-BLCA were used as validation cohort. Bootstrap analysis was performed for internal validation and the clinical net benefit of 5′-tRF-LysCTT on disease prognosis was assessed by decision curve analysis. Elevated 5′-tRF-LysCTT was associated with unfavorable disease features, and significant higher risk for early progression (multivariate Cox: HR = 2.368; p = 0.033) and poor survival (multivariate Cox: HR = 2.151; p = 0.032) of NMIBC and MIBC patients, respectively. Multivariate models integrating 5′-tRF-LysCTT with disease established markers resulted in superior risk-stratification specificity and positive prediction of patients’ progression. In conclusion, increased 5′-tRF-LysCTT levels were strongly associated with adverse disease outcome and improved BlCa patients’ prognostication.

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A 3′-tRNA-derived fragment enhances cell proliferation, migration and invasion in gastric cancer by targeting FBXO47

Cited by 49 publications

References 55 publications

Hijacking tRNAs From Translation: Regulatory Functions of tRNAs in Mammalian Cell Physiology

Hijacking tRNAs From Translation: Regulatory Functions of tRNAs in Mammalian Cell Physiology

Low expression of tRF‐Pro‐CGG predicts poor prognosis in pancreatic ductal adenocarcinoma

tRNA-Derived Fragments (tRFs) in Bladder Cancer: Increased 5′-tRF-LysCTT Results in Disease Early Progression and Patients’ Poor Treatment Outcome

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