Dimensionality aspects of non-minimal electromagnetic couplings are investigated. By means of the Foldy-Wouthuysen transformation, we attain (non-)relativistic interactions related to the non-minimal coupling in three-dimensional spacetime, for both the bosonic and fermionic fields.Next, we establish some comparisons and analyse particular situations in which the external electromagnetic fields are described either by Maxwell or Maxwell-Chern-Simons Electrodynamics. In addition, we consider the situation of a non-minimal coupling for the fermionic field in four dimensions, carry out its dimensional reduction to three dimensions and show that the three-dimensional scenario previously worked out can be recovered as a particular case. Finally, we discuss a number of structural aspects of both procedures.