A simplified Code Division Multiple Access (CDMA) technique has been used to cancel crosstalk in a four-wire signaling high-speed I/O system [1]. To further improve the crosstalk suppression and power efficiency, transmitter (TX) timing adjustment in conjunction with the CDMA-based I/O system is proposed. The integrated transceiver achieves an aggregate 16 Gb/s (5.33 Gb/s/link) data rate and 6 mW/Gb/s/wire power efficiency over four 6" FR4 PCB traces with BER < 10 -12 in a 90 nm standard CMOS technology.