Bio-drying is an important method to reduce the excess sludge which use the inner biomass of sludge itself to generate heat for a water discharging has a broad prospects in sludge treatment. However, our research in this field is still very limited. In order to better mastering and promoting sludge bio-drying technology, this paper summarized the advantages of bio-drying, initially described the microbial mechanism of spontaneous heat generation and the heat and mass transfer phenomena in a bio-drying process, then build a macro heat conservation formula based on material conservation.