A 28-Day Study of the Effect of Coated VICRYL* Plus Antibacterial Suture (Coated Polyglactin 910 Suture with Triclosan) on Wound Healing in Guinea Pig Linear Incisional Skin Wounds

Storch, Mark; Perry, Larry; Davidson, Jeffrey M.; Ward, James J.

doi:10.1089/sur.2002.3.s1-89

Cited by 38 publications

(22 citation statements)

References 14 publications

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“…These coatings are referred to as active release coatings. To date, only a handful of these coatings have been put into clinical use [5,10,12–23]. Clinical studies have shown that these coatings have had minimal to no success in reducing rates of infection in patients [5,10,12–24].…”

Section: Introductionmentioning

confidence: 99%

In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection

et al. 2012

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Active release antimicrobial coatings for medical devices have been developed to prevent and treat biofilm implant-related infections. To date, only a handful of coatings have been put into clinical use, with limited success. In this study, a novel antimicrobial compound was incorporated into a silicone (polydimethylsiloxane or PDMS) polymer to develop a novel active release coating that addressed several limitations of current device coatings. The efficacy of this coating was optimized using an in vitro flow cells system, then translated to an animal model of a simulated Type IIIB open fracture wherein well-established biofilms were used as initial inocula. Results indicated that the novel coating was able to prevent infection in 100% (9/9) of animals that were treated with biofilms and the novel coating (treatment group). In contrast, 100% (9/9) of animals that were inoculated with biofilms and not treated with the coating (positive control), did develop infection. Nine animals were used as negative controls, i.e., those that were not treated with biofilms, and showed a rate of infection of 11% (1/9). Eight animals were treated with the novel coating only to determine its effect on host tissue. Results indicated that the novel active release coating may have significant promise for future application to prevent biofilm implant-related infections in patients.

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Section: Introductionmentioning

confidence: 99%

In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection

et al. 2012

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“…Thereafter 10 3.6 CFU were isolated from nonantimicrobially active suture material in contrast to 10 1.85 CFU in triclosan-impregnated sutures (p Ͻ 0.05) [Storch et al, 2002a[Storch et al, , 2004. The addition of triclosan to the suture did not influence physical properties and the handling of the device [Storch et al, 2002b].…”

Section: Prevention Of Postoperative Wound Infectionsmentioning

confidence: 90%

Hygienic Relevance and Risk Assessment of Antimicrobial-Impregnated Textiles

Krämer¹,

Heldt³

et al. 2006

Biofunctional Textiles and the Skin

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The antimicrobial impregnation of textiles is intended to provide protection of textiles against microbial corrosion, prevention of malodor or prophylaxis and therapy of infections, respectively. For every biocidal product a careful risk assessment for humans and the environment has to be performed. The advantage of antimicrobially active textiles has to be documented for every agent as well as for every application, and a balance has to be found between a textile's quality rating and the potential risks, e.g. sensitization, disturbance of the ecology of the skin, toxic side effects by means of systemic absorption, cytotoxicity, genotoxicity, carcinogenicity, teratogenicity and ecotoxicity. This article evaluates the applicability of silver compounds as well as the classic antimicrobials triclosan, quaternary ammonium compounds, copper and further new options like chitosan and zeolite. It has to be emphasized that there are no objections against the use of antimicrobially active textiles if their use is equal or superior to other preventive or therapeutic measures. This applies to the amelioration of the course of dermatological diseases with disturbed skin flora, in particular atopic dermatitis, the prevention and therapy of acute and chronic wound infections by wound dressings, the use of impregnated surgical suture material as well as special indications in the prevention of infection in medical facilities. The use of antimicrobial textiles for the prevention of dermatomycosis by antifungal impregnation is of questionable use; the antimicrobial impregnation of textiles for deodorization purposes has to be avoided. Presently, from a hygienic point of view, the following questions have to be clearly determined: declaration of any antimicrobial impregnation; development of international standards for in vitro testing and preclinical evaluation of efficacy and tolerance; evaluation of the advantage of the antimicrobial properties for the intended use including the risk-benefit assessment.

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“…The second method measured tensile strength ex vivo, when porcine skin strips that were glued together are pulled apart by mechanical clamps. Both of these methods have been previously used and reported 8,9 and are used to measure the performance of wound closure devices.…”

Section: Study Protocolmentioning

confidence: 99%

A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives

Singer

Perry²

2012

Academic Emergency Medicine

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Objectives: Topical skin adhesives (TSAs) offer a noninvasive alternative to sutures. The growing trend is to use them in addition to sutures and staples to add strength and provide a microbial barrier. The authors compared the mechanical characteristics of recently approved TSAs that are most likely to be of surgical relevance in the emergency department.Methods: Linear incisions were made on anesthetized swine and the wounds were approximated with one of six commercially available TSAs. Three-dimensional bursting strength was measured with a BTC-2000TM device. Tensile failure force was measured ex vivo using TSA-approximated porcine skin strips with a tensionometer. Resistance to cyclic loading was measured by subjecting approximated skin strips to repetitive cycles of rotational torque and linear tension. Viscosity was measured with a viscometer and setting times were measured by periodically dabbing the adhesive applied to skin strips with a cotton swab to determine whether it was dry.Results: Dermabond Advanced TSA provided significantly (p < 0.00001) greater acute in vivo wound bursting strength and ex vivo tensile force, greater mean number of normal tensile loading cycles to failure (while under continuous torsional cycling), and longest time to failure, and the mean setting time was the shortest.

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A 28-Day Study of the Effect of Coated VICRYL* Plus Antibacterial Suture (Coated Polyglactin 910 Suture with Triclosan) on Wound Healing in Guinea Pig Linear Incisional Skin Wounds

Abstract: Based on the in vivo biomechanical testing and histological results, no evidence of impedance to wound healing was detected.

Cited by 38 publications

References 14 publications

In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection

In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection

Hygienic Relevance and Risk Assessment of Antimicrobial-Impregnated Textiles

A Comparative Study of the Surgically Relevant Mechanical Characteristics of the Topical Skin Adhesives

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