2007
DOI: 10.1001/jama.297.5.509
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A 27-Year-Old Woman With a Diagnosis of Polycystic Ovary Syndrome

Abstract: Background: Polycystic ovary syndrome and oligomenorrhea which is one of its complications are considered as the most common causes of menstrual disorders which increases the risk of depression and psychological effects complications. The prevalence of oligomenorrhea is predicted to be 12 to 15 percent. This syndrome occurs with symptoms such as obesity, impaired glucose metabolism, dysmenorrhea, oligomenorrhea and other symptoms. In addition, incidence of decreased libido, painful sexual intercourse and decre… Show more

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Cited by 23 publications
(22 citation statements)
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“…In addition, we did not find that hyperandrogenemia or menstrual abnormalities were associated with infertility in late reproductive age black or white women. The lack of an association between hyperandrogenemia, menstrual irregularity, and infertility is inconsistent with the literature on PCOS (25)(26)(27)(28). It is possible that our lack of findings regarding hyperandrogenemia may be due to low prevalence of PCOS or clinically significant hyperandrogenemia in our population, low precision of the total testosterone assay, or to the relatively older average age of our sample compared to other studies of PCOS (13).…”
Section: Discussioncontrasting
confidence: 81%
“…In addition, we did not find that hyperandrogenemia or menstrual abnormalities were associated with infertility in late reproductive age black or white women. The lack of an association between hyperandrogenemia, menstrual irregularity, and infertility is inconsistent with the literature on PCOS (25)(26)(27)(28). It is possible that our lack of findings regarding hyperandrogenemia may be due to low prevalence of PCOS or clinically significant hyperandrogenemia in our population, low precision of the total testosterone assay, or to the relatively older average age of our sample compared to other studies of PCOS (13).…”
Section: Discussioncontrasting
confidence: 81%
“…There is also no evidence that biochemical indices of IR (other than plasma glucose values derived from a GTT) offer any therapeutic or prognostic value in women with PCOS; neither does it predict weight loss (insulin resistant subjects with PCOS do not respond differently to weight loss interventions compared to PCOS subjects who are not IR). 67 The assessment of IR is therefore a clinical one based on conventional criteria for the metabolic syndrome. The biochemical assessment of insulin levels and its derived indices currently has no merit in clinical practice and increases the cost of managing this condition unnecessarily.…”
Section: Metabolic Consequences Of Pcosmentioning
confidence: 99%
“…[4][5][6] Other potential etiologies must be excluded such as thyroid disease, hyperprolactinemia, ovarian failure, androgen secreting tumors, and congenital adrenal hyperplasia. [4][5][6] Common hyperandrogenic symptoms include acne and/or hirsutism with a modified Ferriman-Gallwey score Z6, usually owing to increased midline androgen-dependent hair growth, and less commonly androgenic alopecia, whereas laboratory testing may indicate elevated levels of total or bioavailable testosterone and dehydroepiandrosterone sulfate. [4][5][6] Follicular phase ultrasound suggests polycystic ovary morphology when either ovary has Z12 follicles each <10 mm diameter or when the volume of either ovary is Z10 cm 3 , in the absence of dominant follicles or large ovarian cysts.…”
Section: Diagnosis and Workup Of Pcosmentioning
confidence: 99%
“…[4][5][6] Common hyperandrogenic symptoms include acne and/or hirsutism with a modified Ferriman-Gallwey score Z6, usually owing to increased midline androgen-dependent hair growth, and less commonly androgenic alopecia, whereas laboratory testing may indicate elevated levels of total or bioavailable testosterone and dehydroepiandrosterone sulfate. [4][5][6] Follicular phase ultrasound suggests polycystic ovary morphology when either ovary has Z12 follicles each <10 mm diameter or when the volume of either ovary is Z10 cm 3 , in the absence of dominant follicles or large ovarian cysts. [4][5][6] An elevated luteinizing hormone to follicle stimulating hormone ratio is not required as false negative findings can occur owing to the pulsatile nature of these hormones and the attenuated ratios frequently seen with obesity.…”
Section: Diagnosis and Workup Of Pcosmentioning
confidence: 99%
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