A 27‐year‐old female presented with diffuse alveolar haemorrhage due to breast angiosarcoma with lung metastasis

Abstract

Angiosarcomas are rare soft‐tissue sarcomas of endothelial cell origin and have a poor prognosis. Diffuse alveolar haemorrhage (DAH) is a syndrome characterized by the accumulation of intra‐alveolar red blood cells. However, neoplastic diseases are not commonly considered in the differential diagnosis of DAH. We report a case of a 27‐year‐old female with the diagnosis of primary breast angiosarcoma developing DAH. This raised our concern that angiosarcoma with lung metastasis may present with DAH and should be considered as an important fatal differential diagnosis of DAH.

Diffuse alveolar hemorrhage from metastatic cardiac angiosarcoma of the lung successfully treated with paclitaxel chemotherapy: A case report and brief literature review

“…The clinical features of angiosarcoma vary according to the tumor site, ranging from asymptomatic cutaneous papule to deeper site bleeding, hemothorax, and pain. Although the lung is the most common site of metastasis, diffuse alveolar hemorrhage (DAH) is a very rare manifestation of pulmonary metastatic angiosarcoma, and most case reports have shown extremely poor prognosis [ [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] ]. We report a case to illustrate the clinical importance of proper diagnosis and treatment in patients with metastatic angiosarcoma with these dangerous clinical presentations.…”