A 25-year experience with pediatric anti-glomerular basement membrane disease

Williamson, Sean R.; Phillips, Carrie L.; Andreoli, Sharon P.; Nailescu, Corina

doi:10.1007/s00467-010-1663-2

Cited by 43 publications

(30 citation statements)

References 17 publications

(24 reference statements)

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“…Anti-GBM glomerulonephritis is rare in children. [18] Our study included only one patient of pediatric anti-GBM nephritis. Cui et al .…”

Section: Discussionmentioning

confidence: 99%

Anti-glomerular basement membrane crescentic glomerulonephritis: A report from India and review of literature

Gupta¹,

Agrawal²,

Kaul³

et al. 2016

Indian J Nephrol

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Anti-glomerular basement membrane (anti-GBM) disease is an autoimmune disease that most commonly presents as rapidly progressive glomerulonephritis with or without pulmonary involvement. It is characterized by the presence of antibodies directed to antigenic targets within glomerular and alveolar basement membranes. This study was performed to evaluate the clinicopathological features and outcome in anti-GBM crescentic glomerulonephritis (CrGN) at a tertiary care center in North India over a period of 9 years (January 2004 to December 2012). A diagnosis of anti-GBM CrGN was made in the presence of >50% crescents, linear deposits of IgG along GBM, and raised serum anti-GBM antibody titer. Of 215 cases of CrGN diagnosed during this period, 11 had anti-GBM CrGN. Anti-GBM CrGN was found at all ages but was most common in the third to fifth decade with no gender predilection (mean age 48 +/- 15 years, 13–67 years). Patients presented with a mean serum creatinine of 10.2 +/- 5.3 mg/dl and sub-nephrotic proteinuria. Pulmonary involvement was present in two patients. Myeloperoxidase-antineutrophil cytoplasmic antibody was positive in two (2/11) elderly patients. Follow-up was available in four patients for a range of 30-270 (mean 99.5 ± 114.5) days, two remained dialysis dependent while two died due to uremia and sepsis. Our findings show that anti-GBM disease is a rare cause of CrGN in India, accounting for only 5% of patients. It usually presents as a renal-limited disease and is associated with a poor renal outcome.

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“…Anti-GBM glomerulonephritis is rare in children. [18] Our study included only one patient of pediatric anti-GBM nephritis. Cui et al .…”

Section: Discussionmentioning

confidence: 99%

Anti-glomerular basement membrane crescentic glomerulonephritis: A report from India and review of literature

Gupta¹,

Agrawal²,

Kaul³

et al. 2016

Indian J Nephrol

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“…Anti-GBM GN and GP disease have been repeatedly associated with cigarette smoking and inhalational exposure to hydrocarbons [9, 52–55]. It is speculated that inhaled toxins promote anti-GBM autoantibody production by exposing collagen epitopes in injured alveoli.…”

Section: Gene and Environmental Susceptibility In Anti-gbm Gnmentioning

confidence: 99%

Basement membranes and autoimmune diseases

Foster

2017

Matrix Biology

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Basement membrane components are targets of autoimmune attack in diverse diseases that destroy kidneys, lungs, skin, mucous membranes, joints, and other organs in man. Epitopes on collagen and laminin, in particular, are targeted by autoantibodies and T cells in anti-glomerular basement membrane glomerulonephritis, Goodpasture’s disease, rheumatoid arthritis, post-lung transplant bronchiolitis obliterans syndrome, and multiple autoimmune dermatoses. This review examines major diseases linked to basement membrane autoreactivity, with a focus on investigations in patients and animal models that advance our understanding of disease pathogenesis. Autoimmunity to glomerular basement membrane type IV is discussed in depth as a prototypic organ-specific autoimmune disease yielding novel insights into the complexity of anti-basement membrane immunity and the roles of genetic and environmental susceptibility.

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“…The recent literature shows that an initial insult to the pulmonary vasculature is required for exposure of the alveolar capillaries to the anti-GBM antibodies, and predisposing factors for such exposure include the following: association with HLA-DR15, exposure to organic solvents or hydrocarbons, smoking, infection, cocaine inhalation, exposure to metal dusts and lymphocyte-depletion therapy [6,[8][9][10]. Our patient was a young 21-year-old woman with no medical history.…”

Section: Discussionmentioning

confidence: 90%

Diffuse Alveolar Haemorrhage Complicated by Pulmonary Embolism—Problems with Treatment

Fijołek¹,

Wiatr²,

Jakubowska³

et al. 2017

Advances in Respiratory Medicine

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Diffuse alveolar haemorrhage (DAH) refers to a clinical syndrome resulting from injury of the alveolar capillaries, arterioles and venules leading to red blood cel accumulation in the distal air spaces. The conditions associated with DAH and underlying disease determine the prognosis and the treatment regimen. The coexistence of DAH with venous thromboembolism (VTE) is a seroius problem for clinicians and poses a challenge in the therapeutic management. We describe a young patient who developed massive DAH in the course of anti-glomerular basement membrane (anti-GBM) disease (formerly called Goodpasture's syndrome) complicated by pulmonary embolism (PE).

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A 25-year experience with pediatric anti-glomerular basement membrane disease

Cited by 43 publications

References 17 publications

Anti-glomerular basement membrane crescentic glomerulonephritis: A report from India and review of literature

Anti-glomerular basement membrane crescentic glomerulonephritis: A report from India and review of literature

Basement membranes and autoimmune diseases

Diffuse Alveolar Haemorrhage Complicated by Pulmonary Embolism—Problems with Treatment

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