A 24-h Pneumoperitoneum Leads to Multiple Organ Impairment in a Porcine Model

Schachtrupp, A.; Toens, C.; Höer, J.; Klosterhalfen, B.; Lawong, A.G.; Schumpelick, Volker

doi:10.1006/jsre.2002.6421

Cited by 69 publications

(72 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Once again, no difference was found between CO 2 and helium, indicating that both gases had similar effects on urine concentration. Similar levels of serum sodium, urea and creatinine between PP and control groups have also been reported elsewhere 4,8,16 . Serum potassium increased in the helium and CO 2 groups, although statistical significance was only reached in the latter.…”

Section: Discussionsupporting

confidence: 84%

“…Both groups subjected to PP exhibited oliguria, an effect repeatedly reported in previous studies [4][5][6][7][8][9][10][11]16 . No difference was observed regardless of whether CO 2 or helium was used for insufflation.…”

Section: Discussionsupporting

confidence: 70%

“…Another limitation of the experiment was the relatively short duration of PP (90 minutes). Some studies employed longer periods (as long as 24h 16 from immediately after PP 13,16 to some hours 11 , days 15 and even a year after PP 14 . Only one study has reported transient changes directly related to the insufflation pressure applied 16 , whereas all other investigations have failed to observe any significant histopathological changes 11,[13][14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

“…Histopathological changes have also been assessed, although they are reported only occasionally in the literature 2,4,11,[13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of pneumoperitoneum with carbon dioxide and helium on renal function and morphology in rats

Freitas¹,

Durães²,

Carvalho³

et al. 2013

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To evaluate the effects of pneumoperitoneum with carbon dioxide and helium on renal function and morphology in a rat model. METHODS:Twenty four rats were randomized into three groups (n=8): gasless insufflation ('open', Pressure=0 mmHg), carbon dioxide pneumoperitoneum at 12 mmHg, and helium pneumoperitoneum at 12 mmHg; all lasting 90 minutes.. A cystostomy was performed and the bladder was emptied. At the end of the experiment, the urine produced, a blood sample and the left kidney of each animal were collected. The following variables were obtained: serum sodium, potassium, urea and creatinine, urine volume and creatinine. The creatinine clearance was estimated for each animal. The kidneys were stained with hematoxylin and eosin (HE) and evaluated by a pathologist blinded to the groups. RESULTS:The CO 2 and Helium groups did not differ in the variables evaluated. Both developed oliguria (p<0.001 vs. gasless). The CO 2 group presented hyperkalemia compared to gasless (p=0.05), which did not attain significance in the helium group. Histopathological analysis revealed mild hydropic degeneration and congestion in the three groups, with no significant difference among them. CONCLUSIONS:The type of gas resulted in no difference in the variables of renal function and morphology assessed. The increase in serum potassium was only observed with CO 2 insufflation suggests a combined effect of elevated intra-abdominal pressure and metabolic effects of pneumoperitoneum.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

“…Histopathological changes have also been assessed, although they are reported only occasionally in the literature 2,4,11,[13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of pneumoperitoneum with carbon dioxide and helium on renal function and morphology in rats

Freitas¹,

Durães²,

Carvalho³

et al. 2013

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Recently, this range has been reduced to 10-15 mm Hg [18]. But in some gynecological laparoscopic procedures, 20 mm Hg IAP is required.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Different Intraabdominal Pressure Protocols in Laparoscopic Procedures on Oxidative Stress Markers and Morphology in Rat Ovaries

Biler¹,

Yücebilgin²,

Şendağ³

et al. 2014

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. To determine the effects of different intraabdominal pressure (IAP) on the ovaries in a laparoscopic rat model. Objectives. The aim of the study was to determine the effects on the ovaries of different intraabdominal pressures (IAP) in laparoscopic surgery in a rat model. Material and Methods. Thirty-two post-pubertal nonpregnant Sprague-Dawley rats were divided randomly into four groups. In the control group, no intraabdominal pressure (IAP) was applied. In Group Pp10 and Group Pp15, an IAP of 10 and 15 mm Hg, respectively, were applied by carbon dioxide insufflation for 60 min, and a 30-min desufflation was carried out. In Group IPp15, a 15 mm Hg IAP was applied for 10 min, and then CO 2 was desufflated for 10 min. After this ischemic preconditioning, IAP was established at 15 mm Hg for 60 min, after which CO 2 was desufflated for 30 min. Erythrocyte and ovarian tissue malondialdehyde (MDA) and histopathologic damage scores were evaluated. Results. In Groups Pp10 and Pp15, ovarian tissue MDA values were significantly increased compared to the control group. In Groups Pp10 and Pp15, erythrocyte MDA values were significantly increased when compared to Group IPp15 and the control group. Ovarian histopatological assesment scores were significantly higher in Group Pp15 than in Groups Pp10 and IPp15. Conclusions. Pneumoperitoneum causes injuries to abdominal organ such as the ovaries. The ischemic preconditioning method is more effective in reducing oxidative stress due to laparoscopic pneumoperitoneum than lowpressure pneumoperitoneum methods (Adv Clin Exp Med 2014, 23, 6, 885-892).

show abstract

Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives

et al. 2020

View full text Add to dashboard Cite

Venous congestion has emerged as an important cause of renal dysfunction in patients with cardiorenal syndrome. However, only limited progress has been made in differentiating this haemodynamic phenotype of renal dysfunction, because of a significant overlap with pre‐existing renal impairment due to long‐term hypertension, diabetes, and renovascular disease. We propose congestive nephropathy (CN) as this neglected clinical entity. CN is a potentially reversible subtype of renal dysfunction associated with declining renal venous outflow and progressively increasing renal interstitial pressure. Venous congestion may lead to a vicious cycle of hormonal activation, increased intra‐abdominal pressure, excessive renal tubular sodium reabsorption, and volume overload, leading to further right ventricular (RV) stress. Ultimately, renal replacement therapy may be required to relieve diuretic‐resistant congestion. Effective decongestion could preserve or improve renal function. Congestive acute kidney injury may not be associated with cellular damage, and complete renal function restoration may be a confirmatory diagnostic criterion. In contrast, a persistently low renal perfusion pressure might induce renal dysfunction and histopathological lesions with time. Thus, urinary markers may differ. CN is mostly seen in biventricular heart failure but may also occur secondary to pulmonary arterial hypertension and elevated intra‐abdominal pressure. An increase in central venous pressure to >6 mmHg is associated with a steep decrease in glomerular filtration rate. However, the central venous pressure range that can provide an optimal balance of RV and renal function remains to be determined. We propose criteria to identify cardiorenal syndrome subgroups likely to benefit from decongestive or pulmonary hypertension‐specific therapies and suggest areas for future research.

show abstract

A 24-h Pneumoperitoneum Leads to Multiple Organ Impairment in a Porcine Model

Cited by 69 publications

References 28 publications

Effects of pneumoperitoneum with carbon dioxide and helium on renal function and morphology in rats

Effects of pneumoperitoneum with carbon dioxide and helium on renal function and morphology in rats

The Effects of Different Intraabdominal Pressure Protocols in Laparoscopic Procedures on Oxidative Stress Markers and Morphology in Rat Ovaries

Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives

Contact Info

Product

Resources

About