A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on

Boutari, Chrysoula; Mantzoros, Christos S.

doi:10.1016/j.metabol.2022.155217

Cited by 425 publications

(292 citation statements)

References 45 publications

(45 reference statements)

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“…Obesity, a complex multifactorial disease, is one of the leading causes of preventable morbidity and mortality in the Western world [1,2]. While its prevalence is rising exponentially, with 1 out of 2 adults in the US expected to be obese by 2030 [3], its management remains challenging [4,5].…”

Section: Introductionmentioning

confidence: 99%

Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity

et al. 2022

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“…The worldwide prevalence of obesity has nearly tripled since 1975, and, currently, 60% of citizens in Europe are either overweight or obese [ 50 ]. AT dysfunctions contribute to obesity-related metabolic diseases.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Adipogenic Differentiation of Human Dental Pulp Stem Cells in Enzymatically Decellularized Adipose Tissue Solid Foams

García-Urkia

Luzuriaga

Uribe-Etxebarria

et al. 2022

Biology

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Engineered 3D human adipose tissue models and the development of physiological human 3D in vitro models to test new therapeutic compounds and advance in the study of pathophysiological mechanisms of disease is still technically challenging and expensive. To reduce costs and develop new technologies to study human adipogenesis and stem cell differentiation in a controlled in vitro system, here we report the design, characterization, and validation of extracellular matrix (ECM)-based materials of decellularized human adipose tissue (hDAT) or bovine collagen-I (bCOL-I) for 3D adipogenic stem cell culture. We aimed at recapitulating the dynamics, composition, and structure of the native ECM to optimize the adipogenic differentiation of human mesenchymal stem cells. hDAT was obtained by a two-enzymatic step decellularization protocol and post-processed by freeze-drying to produce 3D solid foams. These solid foams were employed either as pure hDAT, or combined with bCOL-I in a 3:1 proportion, to recreate a microenvironment compatible with stem cell survival and differentiation. We sought to investigate the effect of the adipogenic inductive extracellular 3D-microenvironment on human multipotent dental pulp stem cells (hDPSCs). We found that solid foams supported hDPSC viability and proliferation. Incubation of hDPSCs with adipogenic medium in hDAT-based solid foams increased the expression of mature adipocyte LPL and c/EBP gene markers as determined by RT-qPCR, with respect to bCOL-I solid foams. Moreover, hDPSC capability to differentiate towards adipocytes was assessed by PPAR-γ immunostaining and Oil-red lipid droplet staining. We found out that both hDAT and mixed 3:1 hDAT-COL-I solid foams could support adipogenesis in 3D-hDPSC stem cell cultures significantly more efficiently than solid foams of bCOL-I, opening the possibility to obtain hDAT-based solid foams with customized properties. The combination of human-derived ECM biomaterials with synthetic proteins can, thus, be envisaged to reduce fabrication costs, thus facilitating the widespread use of autologous stem cells and biomaterials for personalized medicine.

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“…[2][3][4][5] Body mass index remained stable across birth cohorts in this study unlike the temporal trend of increasing BMI observed in many other industrialized nations. 6 Notably, mean BMI was normal for two of the four birth cohorts (<25 kg/m 2 ), and the reported mean BMIs in the other two cohorts were 25.0 and of 25.2 kg/m 2 . With minimal variation in BMI and no change over time, assessment of the impact of BMI on the outcome is a futile exercise.…”

mentioning

confidence: 81%

Increasing vasomotor symptoms: did your great grandmother really not feel them?

Reed

2022

Menopause

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A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on

Cited by 425 publications

References 45 publications

Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity

Circulating total and intact GDF-15 levels are not altered in response to weight loss induced by liraglutide or lorcaserin treatment in humans with obesity

Enhanced Adipogenic Differentiation of Human Dental Pulp Stem Cells in Enzymatically Decellularized Adipose Tissue Solid Foams

Increasing vasomotor symptoms: did your great grandmother really not feel them?

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