A 2011 Updated Systematic Review and Clinical Practice Guideline for the Management of Malignant Extradural Spinal Cord Compression

Loblaw, D.A.; Mitera, Gunita; Ford, Michael; Laperrière, Normand

doi:10.1016/j.ijrobp.2012.01.014

Cited by 128 publications

(78 citation statements)

References 28 publications

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“…In this updated review of patterns of practice in the rrrp for 2005-2012, most radiation therapy for bone metastases continued to be delivered in a single fraction, which accords with established practice guidelines 2,30 . Reason for multiple treatments…”

Section: Discussionmentioning

confidence: 99%

“…That analysis had not been conducted in the earlier study, and it revealed that dose fractionation schedules of 20 Gy/5 and 30 Gy/10 were commonly prescribed for complicated bone metastases: for example, in cord compression or pathologic fracture requiring postoperative radiation therapy. Several studies examining radiation therapy used to treat spinal cord compression revealed that no specific treatment schedules proved to be more advantageous than others 30 . Fractionated treatment schedules such as 30 Gy/10 and 20 Gy/5 are typically administered to manage spinal cord compression in patients receiving only radiation therapy 2,31,32 .…”

Section: Discussionmentioning

confidence: 99%

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Patterns of Practice in the Prescription of Palliative Radiotherapy for the Treatment of Bone Metastases at the Rapid Response Radiotherapy Program between 2005 and 2012

et al. 2013

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Objective: We examined whether patterns of practice in the prescription of palliative radiation therapy for bone metastases had changed over time in the Rapid Response Radiotherapy Program (RRRP). Methods: After reviewing data from August 1, 2005, to April 30, 2012, we analyzed patient demographics, diseases, organizational factors, and possible reasons for the prescription of various radiotherapy fractionation schedules. The chi-square test was used to detect differences in proportions between unordered categorical variables. Univariate logistic regression analysis and the simple Fisher exact test were also used to determine the factors most significant to choice of dose–fractionation schedule. Results: During the study period, 2549 courses of radiation therapy were prescribed. In 65% of cases, a single fraction of radiation therapy was prescribed, and in 35% of cases, multiple fractions were prescribed. A single fraction of radiation therapy was more frequently prescribed when patients were older, had a prior history of radiation, or had a prostate primary, and when the radiation oncologist had qualified before 1990. Conclusions: For patients with bone metastasis, a single fraction of radiation therapy was prescribed with significantly greater frequency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Patterns of Practice in the Prescription of Palliative Radiotherapy for the Treatment of Bone Metastases at the Rapid Response Radiotherapy Program between 2005 and 2012

et al. 2013

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“…Due to an increase in the survival times of patients with malignancies, the incidence of SBM is expected to rise over the years [1,2]. The majority of symptomatic SBM are caused by breast, prostate and lung cancer (56-74%) [3][4][5] and most commonly arise from the thoracic part of the spine (51-67%) [4,6].…”

Section: Introductionmentioning

confidence: 99%

A systematic review of prognostic factors predicting survival in patients with spinal bone metastases

et al. 2017

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Results After screening, 142 full-text articles were obtained, of which 22 met the eligibility criteria. A total of 43 different prognostic factors were investigated in the included studies, of which 17 were relevant to pre-treatment survival estimation. The prognostic factors most frequently associated with survival were the primary tumor and the performance status. The prognostic factors most frequently not associated with survival were age, gender, number and location of the SBM and the presence of a pathologic fracture. Conclusions Prognostication for patients with SBM should be based on an accurate primary tumor classification, combined with a performance score. The benefit of adding other prognostic factors is doubtful.

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“…Not all patients were routinely offered positron emission tomography (PET) scan or bone scintigraphy (BS), and due to this, there is a degree of uncertainty in the information on number of metastases to extra spinal bone foci. However, PET or BS scans are not offered routinely to all patients with acute MSCC because of the need for urgent treatment and neither to all patients with spinal metastases (Padalkar and Tow 2011;Wang et al 2012;Quraishi et al 2013;Park et al 2011;Akram and Allibone 2010;Putz et al 2008;Moon et al 2011;Rades et al 2010;Loblaw et al 2005Loblaw et al , 2012. Future, prospective studies should focus on the effect of excluding this variable from the Tokuhashi Revised score.…”

Section: Discussionmentioning

confidence: 99%

Moderate precision of prognostic scoring systems in a consecutive, prospective cohort of 544 patients with metastatic spinal cord compression

Morgen

Hallager

Larsen

et al. 2014

J Cancer Res Clin Oncol

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A 2011 Updated Systematic Review and Clinical Practice Guideline for the Management of Malignant Extradural Spinal Cord Compression

Cited by 128 publications

References 28 publications

Patterns of Practice in the Prescription of Palliative Radiotherapy for the Treatment of Bone Metastases at the Rapid Response Radiotherapy Program between 2005 and 2012

Patterns of Practice in the Prescription of Palliative Radiotherapy for the Treatment of Bone Metastases at the Rapid Response Radiotherapy Program between 2005 and 2012

A systematic review of prognostic factors predicting survival in patients with spinal bone metastases

Moderate precision of prognostic scoring systems in a consecutive, prospective cohort of 544 patients with metastatic spinal cord compression

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