III-V Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs) with a high-κ dielectric gate stack are investigated as a possible route to enhance the performance of either microwave or logic circuits with low supply voltage (VDD). The intrinsic performance of III-V MOSFETs in both static and dynamic regimes under low VDD is estimated using device Monte Carlo simulation. The characteristics of a Bulk-like and XOI-like III-V MOSFETs are quantitatively assessed and compared in terms of DC transconductance, high frequency performance and noise behavior. Finally, the comparison with Si-based devices shows the potential of III-V nano-MOSFET architectures for high-frequency and low noise application under low operating power.