A 20-Year Follow-Up Study of a Case of Surgically Treated Massive Osteolysis

Gorham's Disease or Massive Osteolysis

“…The non-operative options include radiation therapy, 10,21,39,44,60,69,101,112,139,140 anti-osteoclastic medication (bisphosphonates), 109,146 and alpha-2b interferon. 109 The operative options include surgical resection, 10,29,63,69 reconstruction using a bone graft, 30,63 or a prosthesis. 5,42 It is worth noting that the success rate after the use of a bone graft is low.…”

“…Turra and associates 63 have reported a 20-year follow-up of a case of surgically treated massive osteolysis of the humerus that occurred in a male, 19 years of age. The lesion was successfully treated with an autogenous fibular shaft transplant.…”

“…The process may affect the appendicular or the axial skeleton. The shoulder 121,123,126,131 and the pelvis 48,61,95,103,118,145 are the most common sites of involvement, however, various locations such as the humerus, 5,17,63 90 Disease of the ribs, scapula, or thoracic vertebrae may lead to the development of chylothorax from direct extension of lymphangiectasia into the pleural cavity or via invasion of the thoracic duct. 85 Without surgical intervention, patients with Gorham's disease who develop chylothorax have a high rate of morbidity and mortality.…”

Intercalary Bone Grafting for the Reconstruction of Phalangeal Osteolysis in Disappearing Bone Disease: Case Report

“…It is assumed that better results are achieved when surgical treatment is performed during the inactive phases of the disease by using cortical instead of cancellous bone grafts. 3,6,12 However, gradual dissolution of bone grafts in the majority of published cases has made surgical reconstruction a less favorable treatment option in comparison with radiation therapy. 3,4,13 Our search in English and international literature revealed only 4 cases that have had surgery for hand and wrist DBD.…”

A case report of Gorham–Stout syndrome remission

“…Thoracic cage, pulmonary, or pleural involvement leads to compromise of respiratory function and consequent death [3,6]. Visceral complication can occur when the disease invades the surrounding tissues [7]. Recently, interferon and bisphosphonates have been reported to have remissive effects, although the mechanisms are unclear [8,9].…”