A 20-year analysis of previous and emerging allergens that elicit photoallergic contact dermatitis

Victor, Frank; Cohen, David E.; Soter, Nicholas A.

doi:10.1016/j.jaad.2009.06.084

Cited by 82 publications

(52 citation statements)

References 19 publications

(11 reference statements)

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“…Drug-induced photosensitivity is only one form in the line of medical eruptions, and indicates the occurrence of skin lesions caused by simultaneous infl uence of medication and exposure to light [1][2][3][4][5][6][7] . In the past few decades, photosensitivity has been reported with an array of drugs, and is now recognized as a noteworthy medical problem 8 .…”

Section: Introductionmentioning

confidence: 99%

“…Th us, several hundred drugs or substances may provoke phototoxic and photoallergic reactions and the list of those medications has expanded in the last fi ve years 8,12 . Phototoxic reactions become visible very soon upon exposure to the accountable agent (within a few minutes or hours), whereas photoallergic agent visibility appears slowly (within one or three days after contact with the body) 7,9 . Photosensitivity includes a number of interactions and photochemical reactions 8 .…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, in photoallergic reactions, the amount of agent required for photosensitivity is small and the mechanism includes cellmediated immune responses (type IV) to a light-activated compound 9,14 . In phototoxic reaction, distribution includes only sun-exposed skin and clinical characteristics are similar to exaggerated sunburn, whereas photoallergic reaction includes dermatitis (systemic administration of photo-allergen causes a picture of drug eruption, while topical application of the substance causes eczematous morphology) [4][5][6][7][8][9][10] . Generally, drug-induced photosensitivity reactions can occur in persons of any age.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, photoallergic reactions develop only in a minority of individuals exposed to the combination of a compound (mostly systemic drugs) and UV light [6][7][8][9] . Th e amount of drug required to elicit photoallergic reactions is considerably smaller than that required for phototoxic reactions.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, photoallergic reactions to a drug usually manifest as a pruritic eczematous eruption, and in the acute phase there is erythema and vesicles, while more chronic exposure results in erythema, lichenifi cation and scaling [7][8][9][10]15 . Opposed to phototoxic reactions, photoallergic skin lesions can also spread out of the sunexposed area, and hyperpigmentation does not occur.…”

Section: Introductionmentioning

confidence: 99%

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Drug-Induced Photosensitivity – a Continuing Diagnostic Challenge

Lugović-Mihić

Duvančić

Ferček

et al. 2017

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SUMMARY -When taking diff erent drugs, their possible side eff ects on the skin should be considered, including skin reactions connected to photosensitivity. Th is photosensitivity caused by drugs can appear as phototoxic reactions (which occur more often) or photoallergic reactions (which occur less often and include allergic mechanisms). Th e following drugs stand out as medications with a high photosensitivity potential: nonsteroidal anti-infl ammatory drugs (NSAIDs), cardiovascular drugs (such as amiodarone), phenothiazines (especially chlorpromazine), retinoids, antibiotics (sulfonamides, tetracyclines, especially demeclocycline and quinolones), etc. In recent years, photosensitive reactions to newer drugs have appeared, e.g., targeted anticancer therapies such as BRAF kinase inhibitors (vemurafenib, dabrafenib), EGFR inhibitors, VEGFR inhibitors, MEK inhibitors, Bcr-Abl tyrosine kinase inhibitors, etc. In patients taking drugs over a longer period of time (e.g., NSAIDs, cardiovascular drugs, etc.), a particular problem arises when an unrecognized drug-induced photosensitivity on the skin manifests in summer months. When taking patient histories, the physician/dermatovenereologist should bear in mind that any drug the patient is currently taking may be the cause of skin reactions. Th erefore, patients who use potentially photosensitive drugs and treatments on a long term basis should be warned of the possibility of these side eff ects on their skin and advised to avoid direct exposure to sunlight and to use adequate photoprotection. If patients carefully protect themselves from the sun, it is often not necessary to stop treatments that include photosensitive drugs. If such reactions appear, anti-infl ammatory and antiallergic therapies should be introduced.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Drug-Induced Photosensitivity – a Continuing Diagnostic Challenge

Lugović-Mihić

Duvančić

Ferček

et al. 2017

acc

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Cutaneous Photosensitivity Diseases

Ibbotson

Dawe

2016

Rook's Textbook of Dermatology, Ninth Edition

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The photodermatoses are a diverse group of diseases, some of which, such as polymorphic light eruption, are very common and others, such as hydroa vacciniforme or xeroderma pigmentosum, are rare. It is essential not to miss the diagnosis of these conditions and referral to a specialist photodiagnostic centre is advised for many patients. Management depends on the diagnosis but includes prevention and disease suppression. Photoprotection is a mainstay approach for the photodermatoses but is often not sufficient for disease control. Desensitization using photo(chemo)therapy regimens may be feasible and systemic therapies are sometimes needed. Photosensitivity, particularly if chronic and severe, can be associated with significant psychological morbidity, which must be considered. Awareness of the possibility of vitamin D deficiency is also required.

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Microexamination

2019

Common Contact Allergens

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A 20-year analysis of previous and emerging allergens that elicit photoallergic contact dermatitis

Cited by 82 publications

References 19 publications

Drug-Induced Photosensitivity – a Continuing Diagnostic Challenge

Drug-Induced Photosensitivity – a Continuing Diagnostic Challenge

Cutaneous Photosensitivity Diseases

Microexamination

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