A 2‐Year Prospective Study of Human Papillomavirus Persistence among Women with a Cytological Diagnosis of Atypical Squamous Cells of Undetermined Significance or Low‐Grade Squamous Intraepithelial Lesion

Schiffman, Mark; Castle, Philip E.; Maucort-Boulch, Delphine; Wheeler, Cosette M.; Plummer, Martyn

doi:10.1086/516784

Cited by 339 publications

(140 citation statements)

References 28 publications

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“…S1)11, 18, 19 by calibrating the rate of clearance of HPV16 infection. HPV16 clearance rate was found to decrease with time since infection (Supporting Information Table S1), in accordance with empirical evidence 20, 21. The corresponding average duration of HPV16 infection was 11 months.…”

Section: Methodssupporting

confidence: 83%

Impacts of human papillomavirus vaccination for different populations: A modeling study

Baussano

Lazzarato

Ronco³

et al. 2018

Intl Journal of Cancer

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International variations in the prevalence of HPV infection derive from differences in sexual behaviors, which are also a key factor of the basic reproductive number (R0) of HPV infection in different populations. R 0 affects the strength of herd protection and hence the impact of a vaccination program. Similar vaccination programs may therefore generate different levels of impact depending upon the population's pre‐vaccination HPV prevalence. We used IARC's transmission model to estimate (i) the overall effectiveness of vaccination versus no vaccination in women aged 15–34 years measured as percent prevalence reduction (%PR) of HPV16 and (ii) the corresponding herd protection in populations with gender‐equal or traditional sexual behavior and with different levels of sexual activity, corresponding to pre‐vaccination HPV16 prevalence from 1 to 8% as observed worldwide. Between populations with different levels of gender‐equal sexual activity, the highest difference in %PR under girls‐only vaccination is observed at 40% coverage (91%PR vs. 48%PR for 1% and 8% pre‐vaccination prevalence, respectively). HPV16 elimination is obtained with 55 and 97% coverage, respectively. To achieve desirable levels of HPV16 prevalence after vaccination, different levels of coverage are required in populations with different levels of pre‐vaccination HPV16 prevalence, for example, in populations with gender‐equal sexual behavior a decrease to 1/1000 HPV16 from pre‐vaccination prevalence of 1 and 8% would require coverages of 37 and 96%, respectively. In traditional populations, corresponding coverages would need to be 28 and 93%, respectively. In conclusion, pre‐vaccination HPV prevalence strongly influences herd immunity and helps predict the overall effectiveness of HPV vaccination.

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Section: Methodssupporting

confidence: 83%

Impacts of human papillomavirus vaccination for different populations: A modeling study

Baussano

Lazzarato

Ronco³

et al. 2018

Intl Journal of Cancer

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“…Multiple infections are frequent in patients with CIN1 and are found in 50% of these cases (Plummer et al, 2007), while here, we found a greater number of these cases in CIN3 rather than in CIN2. In the present study, the prevalence was single infection with 59.5% of the cases with HPV 16, 31, 52, 53 and 58, and there was statistically significant difference (P = 0.029) when it was compared to multiple infections associated with other HPV types.…”

Section: Discussioncontrasting

confidence: 61%

HPV genotyping and p16 expression in Xingu Indigenous Park, Brazil

et al. 2016

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ABSTRACT. The association between high-risk human papillomavirus (HPV) genotypes and p16 expression in indigenous women from the Xingu Indigenous Park, Brazil, was unknown. This study evaluated p16 expression in women with a histological diagnosis of cervical intraepithelial neoplasia (CIN) 3 or higher and correlated this expression with HPV genotypes to determine possible discrepancies in the expression of this marker. We evaluated 37 previously collected samples with different HPV genotypes and high-grade lesions diagnosed based on cytology, histology, and colposcopy. Immunohistochemical analysis was performed using paraffin-embedded tissue sections and the CINtec ® Histology Kit. p16 protein expression was investigated by immunostaining with an anti-p16 antibody. HPV genotyping was performed by reverse hybridization. The age of the study population ranged from 22-75 years (43.81 ± 15.89 years) and parity ranged from 1-11 (5.92 ± 2.58). Thirteen different HPV genotypes were found using the INNO-LiPA kit. Single and multiple infections by HPV were found with prevalence of single infections (P = 0.029). Comparison between HPV genotype and simple or multiple infections was highly significant; it was observed more HPV 52 followed by HPV 16 in single infections (P < 0.001). p16 expression was predominantly diffuse, which was observed in 91.7% of lesions, whereas 8.3% were focal (P < 0.001). HPV 52, HPV 16 and 31 were the most prevalent HPV types in high-grade CIN in these indigenous women. Diffuse p16 expression in high-grade CIN was not influenced by the viral genotype; however, more studies are necessary to further our understanding of this restricted group.

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“…Most of the infections caused by HPV are of benign evolution and 80-90% is temporary, being eliminated spontaneously by the host organism within 10-18 months; persistence is liable to occur in only 20% of cases, leading to the onset of early lesions and cervical cancer (Kjaer et al, 2002;Plummer et al, 2007;Smith et al, 2007;Winer et al, 2011;Panatto et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less

et al. 2016

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ABSTRACT. We verified the prevalence of human papillomavirus (HPV) E6/E7 protein mRNA expression in patients with low-grade squamous intraepithelial lesions (LSILs) and negative cervicovaginal cytology. To investigate the relationship between mRNA expression and viral infection type, we assessed genotyping in single infections. Samples from 825 women were submitted to the E6/E7 survey. We noticed a larger percentage of E6/E7 mRNA expression in the atypical squamous cells of undetermined significance (ASC-US) and LSIL cytologies. Negative results of mRNA expression were in accordance with negative cytologies. In positive cases, the infection by a single HPV type was most common, with type 16 being most prevalent. The expression of mRNA was most prevalent in ASC-US and LSIL cytologies, compared with the negative cytology. The infection by a HPV type was more frequent in cases of positive expression, with HPV

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A 2‐Year Prospective Study of Human Papillomavirus Persistence among Women with a Cytological Diagnosis of Atypical Squamous Cells of Undetermined Significance or Low‐Grade Squamous Intraepithelial Lesion

Cited by 339 publications

References 28 publications

Impacts of human papillomavirus vaccination for different populations: A modeling study

Impacts of human papillomavirus vaccination for different populations: A modeling study

HPV genotyping and p16 expression in Xingu Indigenous Park, Brazil

Expression of human papillomavirus E6 and E7 oncoprotein mRNA in women with low-grade squamous intraepithelial lesions or less

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