A 2-year feeding study of instant. Coffees in rats. II. Incidence and types of neoplasms

Würzner, H.P.; Lindström, Eva; Vuataz, L.; Luginbühl, H

doi:10.1016/s0015-6264(77)80199-5

Cited by 38 publications

(8 citation statements)

References 12 publications

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“…All studies on oral and intraperitoneal administration of caffeine to mice were found inadequate for evaluation. In one study (Würzner et al, 1977a(Würzner et al, , 1977b, decaffeinated coffee to which caffeine was added was tested by oral administration to rats; overall, no increase in the incidence of tumours at any site was observed as compared to appropriate controls (IARC, 1991).…”

Section: Studies In Experimental Animalsmentioning

confidence: 99%

Intake of caffeine and other methylxanthines during pregnancy and risk for adverse effects in pregnant women and their foetuses

Andersson¹,

Hallström²,

Kihlman³

2005

TemaNord

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Section: Studies In Experimental Animalsmentioning

confidence: 99%

Intake of caffeine and other methylxanthines during pregnancy and risk for adverse effects in pregnant women and their foetuses

Andersson¹,

Hallström²,

Kihlman³

2005

TemaNord

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“…Wurzner et al (45) performed a 2-year feeding study of instant coffees in Sprague-Dawley rats. The average daily coffee intake was 3.5 g/kg for female rats.…”

Section: Caffeine and Rodent Mammary Gland Tumorigenesismentioning

confidence: 99%

Caffeine and the Development of the Normal and Neoplastic Mammary Gland

Welsch

1994

Experimental Biology and Medicine

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There has been much interest in the role of dietary factors in the etiology and progression of breast disease. Due to its wide consumption and the many biochemical and physiological effects it exerts, caffeine has been extensively examined in both clinical and experimental animal studies. To date, clinical studies investigating a possible relationship between caffeine consumption and breast disease in humans have yielded inconsistent and inconclusive results. In experimental animal studies utilizing laboratory mice and rats, caffeine has been shown to stimulate mammary gland lobulo-alveolar development and secretion. The development of mammary gland tumors can be either stimulated or suppressed depending upon the animal species and strain, and the stage of tumorigenesis (initiation/promotion) at which caffeine is administered. Many laboratories have proposed that antagonism of the adenosine receptor is the most plausible mechanism to account for the many biological activities of caffeine. However, other mechanisms by which caffeine act cannot be discounted. The significant modifying role of caffeine on normal and neoplastic mammary gland development in experimental animals provides a biological foundation from which to implicate caffeine as a potential modulator of developmental growth of normal, benign, and carcinomatous human breast tissues.

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“…930 and 2,000 mg/1 for 2 years. Interestingly, also no tumors or hyperplasia occurred in the urinary tract of rats which were given regular or instant coffee for 2 years [39,40]. In analogy, in mice maintained on a diet containing caf feine for 19-20 months or fed regular coffee, no urothe lial tumors were induced [2,27],…”

Section: Effects O F Caffeinementioning

confidence: 99%

“…The underlying mechanisms are completely unknown. Since animal experiments did not indicate a complete, initiat ing carcinogenic effect of caffeine [18,27,31,33] or cof fee [2,39] on the urothelium, we also tested caffeine for a possible cocarcinogenic and/or promoting activity on BBN-initiated urothelial carcinogenesis. The present ex periments were undertaken at the quiescent urinary bladder showing an extremely slow cell renewal as well as at the regenerating bladder stimulated to proliferate by either a partial cystectomy [22] or cyclophosphamide [23], The underlying concept was that an increased cell proliferation might be an enhancing factor in carcino genesis, because proliferating cells are probably more susceptible to carcinogenic or cocarcinogenic agents than resting cells, as has been especially demonstrated in liver carcinogenesis following partial hepatectomy [for review of the literature sec ref.…”

Section: Introductionmentioning

confidence: 99%

Effect of Phenacetin and Caffeine on N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine-Initiated Urothelial Carcinogenesis in Rats

Kunze¹,

Rath²,

Graewe³

1987

Urol Int

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The present experimental study was undertaken to clarify whether phenacetin and caffeine exert a cocarcinogenic and/or promoting effect on N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-initiated urothelial carcinogenesis. BBN was initially administered to female Wistar rats by gavage in 3 consecutive fractionated doses of 100 mg/kg body weight each at 24-hour intervals. Phenacetin was continuously fed at a daily dose of 500 mg/kg body weight, and caffeine was given in the drinking water at a dose of 110 mg/kg body weight/day throughout the experiment. After an experimental period of 21 months the incidence of BBN-induced tumors in the urinary bladder (number of rats with a bladder tumor) had not increased following additional administration of phenacetin alone (47 %) or in combination with caffeine (48 %) compared with the control group, the animals of which received exclusively BBN (44%). However, there was a significant enhancement of a multifocal tumor development (number of rats with more than 1 tumor in the bladder), when additionally phenacetin was fed alone (44% of the tumor-bearing animals) or in combination with caffeine (47%) compared with the control rats treated with BBN alone which showed only solitary tumors. Similarly, the incidence of a multicentric tumor development had increased, although not significantly, following administration of phenacetin alone or simultaneously with caffeine for 15 months. Caffeine revealed no complete initiating carcinogenic potential for the resting as well as the regenerating bladder urothelium stimulated to proliferate by either a partial cystectomy or cyclophosphamide. Furthermore, no cocarcinogenic and/or promoting activity of caffeine on BBN-initiated bladder tumor development was observed. The data obtained suggest a slight promoting and/or cocarcinogenic effect of phenacetin on BBN-initiated bladder carcinogenesis as indicated by an enhancement of a multifocal tumor development.

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A 2-year feeding study of instant. Coffees in rats. II. Incidence and types of neoplasms

Cited by 38 publications

References 12 publications

Intake of caffeine and other methylxanthines during pregnancy and risk for adverse effects in pregnant women and their foetuses

Intake of caffeine and other methylxanthines during pregnancy and risk for adverse effects in pregnant women and their foetuses

Caffeine and the Development of the Normal and Neoplastic Mammary Gland

Effect of Phenacetin and Caffeine on N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine-Initiated Urothelial Carcinogenesis in Rats

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