A 2-week repeated-dose oral toxicity test of Polycalcium, a mixed composition of Polycan and calcium lactate-gluconate 1 : 9 (g/g)

Choi, Jae‐Suk; Shin, Hyun‐Soo; Ha, Yu-Mi; Kim, Ki Young; Ku, Sae Kwang; Choi, Inhee; Kim, Joo Wan

doi:10.1007/s13530-014-0203-z

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The commercial mixture Polycalcium was administered to the animals in the doses of (50, 100, and 200 mg/kg), orally once a day for 28 days from 1 week after surgery. Prior to this study, this same research group carried out a toxicological test of this substance in rats [ 57 ]. In this pilot study, the animals received doses (0, 500, 1000, and 2000 mg/kg in a volume of 10 mL/kg) once a day for 14 days to investigate possible side effects.…”

Section: Beta-glucans and Osteoarthritismentioning

confidence: 99%

Translating Human and Animal Model Studies to Dogs’ and Cats’ Veterinary Care: Beta-Glucans Application for Skin Disease, Osteoarthritis, and Inflammatory Bowel Disease Management

Amaral,

Risolia,

Rentas

et al. 2024

Microorganisms

View full text Add to dashboard Cite

The inclusion of beta-glucans in dog and cat food is associated with numerous beneficial effects on the health of these animals. In this regard, there is an effort to elucidate the potential of this nutraceutical in chronic patients. Since there is a lack of a review on the topic, this review article aims to compile and discuss the evidence found to date. Atopic dermatitis, inflammatory bowel disease, and osteoarthritis are diseases of significant clinical relevance in dogs and cats. In general, the pathophysiology of these chronic conditions is related to immune-mediated and inflammatory mechanisms. Therefore, the immunomodulation and anti-inflammatory effects of beta-glucans are highlighted throughout this review. The available information seems to indicate that the studies on beta-glucans’ impact on allergic processes in dogs indicate a reduction in clinical signs in atopic dermatitis cases. Additionally, while beta-glucans show promise as a safe supplement, particularly for osteoarthritis, further clinical trials are imperative, especially in uncontrolled environments. Beta-glucans emerge as a potential nutraceutical offering immune benefits for inflammatory bowel disease patients, although extensive research is required to define its optimal origin, molecular weight, dosage, and specific applications across animals suffering from this disease.

show abstract

Section: Beta-glucans and Osteoarthritismentioning

confidence: 99%