A 2-D Microcantilever Array for Multiplexed Biomolecular Analysis

Yue, Min; Lin, Hsien-Chung; Dedrick, Daniel E.; Satyanarayana, Srinath; Majumdar, Arun; Bedekar, A.S.; Jenkins, Jerry; Sundaram, S.

doi:10.1109/jmems.2003.823216

Cited by 152 publications

(108 citation statements)

References 15 publications

Supporting

Mentioning

106

Contrasting

Unclassified

Order By: Relevance

“…Figure 4 shows the effect of the packing density of DNA chains on microcantilever deflections predicted by the present model, Utz-Begley's model [16] and Hagan's model [10]. The parameters are taken as l = 300 μm, b = 40 μm, hs = 0.5 μm, h1 = 5 nm, h2 = 25 nm, Es = 85 GPa, E1 = 140 GPa, E2 = 73 GPa [29,30]. The deflection grows with the increase of packing density.…”

Section: Effect Of Chain Length and Packing Density Of Ssdnamentioning

confidence: 99%

Effect of Conformational Entropy on the Nanomechanics of Microcantilever-Based Single-Stranded DNA Sensors

Tan

Zhang

2014

Entropy

View full text Add to dashboard Cite

An entropy-controlled bending mechanism is presented to study the nanomechanics of microcantilever-based single-stranded DNA (ssDNA) sensors. First; the conformational free energy of the ssDNA layer is given with an improved scaling theory of thermal blobs considering the curvature effect; and the mechanical energy of the non-biological layer is described by Zhang's two-variable method for laminated beams. Then; an analytical model for static deflections of ssDNA microcantilevers is formulated by the principle of minimum energy. The comparisons of deflections predicted by the proposed model; Utz-Begley's model and Hagan's model are also examined. Numerical results show that the conformational entropy effect on microcantilever deflections cannot be ignored; especially at the conditions of high packing density or long chain systems; and the variation of deflection predicted by the proposed analytical model not only accords with that observed in the related experiments qualitatively; but also appears quantitatively closer to the experimental values than that by the preexisting models. In order to improve the sensitivity of static-mode biosensors; it should be as small as possible to reduce the substrate stiffness.

show abstract

Section: Effect Of Chain Length and Packing Density Of Ssdnamentioning

confidence: 99%

Effect of Conformational Entropy on the Nanomechanics of Microcantilever-Based Single-Stranded DNA Sensors

Tan

Zhang

2014

Entropy

View full text Add to dashboard Cite

show abstract

“…196 The breakthrough potential afforded by nanocantilevers resides in their extraordinary multiplexing capability. 197 In one study, Majumdar used microcantilevers to detect SNPs in a 10-mer DNA target oligonucleotide without using extrinsic fluorescent or radioactive labeling. 198 Devices based on nanowires are emerging as a powerful and general platform for ultrasensitive, direct electrical detection of biological and chemical species.…”

Section: Ex Vivo Detectionmentioning

confidence: 99%

Nanotechnology-based approaches in anticancer research

Jabir¹,

Tabrez²,

Ashraf³

et al. 2012

IJN

139

View full text Add to dashboard Cite

Cancer is a highly complex disease to understand, because it entails multiple cellular physiological systems. The most common cancer treatments are restricted to chemotherapy, radiation and surgery. Moreover, the early recognition and treatment of cancer remains a technological bottleneck. There is an urgent need to develop new and innovative technologies that could help to delineate tumor margins, identify residual tumor cells and micrometastases, and determine whether a tumor has been completely removed or not. Nanotechnology has witnessed significant progress in the past few decades, and its effect is widespread nowadays in every field. Nanoparticles can be modified in numerous ways to prolong circulation, enhance drug localization, increase drug efficacy, and potentially decrease chances of multidrug resistance by the use of nanotechnology. Recently, research in the field of cancer nanotechnology has made remarkable advances. The present review summarizes the application of various nanotechnology-based approaches towards the diagnostics and therapeutics of cancer.

show abstract

“…19,27 However, this is not straightforward to obtain using polymer cantilevers if the measurement and reference cantilever are functionalized differently. A third approach is to use soft cantilevers with a stiff reflecting pad at the apex as described by Yue et al 28 With a design like this, the 1 / R Ϸ 0 and the effect of changes to the refractive index will always be similar to that of the perfectly straight cantilever regardless of initial bending.…”

Section: ͑1͒mentioning

confidence: 99%

The influence of refractive index change and initial bending of cantilevers on the optical lever readout method

Dohn

Greve

Svendsen

et al. 2010

Review of Scientific Instruments

View full text Add to dashboard Cite

It has been speculated that the initial bending of cantilevers has a major influence on the detector signal in a cantilever-based sensor using the optical lever readout method. We have investigated theoretically as well as experimentally the changes induced in the detector signal when the optical lever technique is used to monitor a cantilever with initial bending during changes in the refractive index of the surrounding media. We find that for changes in refractive index as small as 10−4 the detector signal is highly dependent on the initial bending of the cantilever. The findings are validated experimentally using an environmental chamber and varying the pressure. We sketch routes to circumvent the problem and formulas suitable for data treatment are given.

show abstract

A 2-D Microcantilever Array for Multiplexed Biomolecular Analysis

Cited by 152 publications

References 15 publications

Effect of Conformational Entropy on the Nanomechanics of Microcantilever-Based Single-Stranded DNA Sensors

Effect of Conformational Entropy on the Nanomechanics of Microcantilever-Based Single-Stranded DNA Sensors

Nanotechnology-based approaches in anticancer research

The influence of refractive index change and initial bending of cantilevers on the optical lever readout method

Contact Info

Product

Resources

About