2020
DOI: 10.1093/cid/ciaa126
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A 2-Biomarker Model Augments Clinical Prediction of Mortality in Melioidosis

Abstract: Background Melioidosis, infection caused by Burkholderia pseudomallei, is a common cause of sepsis with high associated mortality in Southeast Asia. Identification of patients at high likelihood of clinical deterioration is important for guiding decisions about resource allocation and management. We sought to develop a biomarker-based model for 28-day mortality prediction in melioidosis. Methods In a derivation set (N = 113) … Show more

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Cited by 8 publications
(8 citation statements)
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“…Others have characterized plasma levels and/or mRNA expression of pro-and anti-inflammatory cytokines in melioidosis patients for similar purposes. For instance, levels of IFN-γ, IL-6, IL-8, IL-10, IL-23, and TNF-α were reported to be higher in melioidosis cases compared with healthy individuals (Kaewarpai et al, 2020 ; Sengyee et al, 2021 ; Wright et al, 2021 ). All of them except IFN-γ were associated with 28-day mortality.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Others have characterized plasma levels and/or mRNA expression of pro-and anti-inflammatory cytokines in melioidosis patients for similar purposes. For instance, levels of IFN-γ, IL-6, IL-8, IL-10, IL-23, and TNF-α were reported to be higher in melioidosis cases compared with healthy individuals (Kaewarpai et al, 2020 ; Sengyee et al, 2021 ; Wright et al, 2021 ). All of them except IFN-γ were associated with 28-day mortality.…”
Section: Discussionmentioning
confidence: 99%
“…All of them except IFN-γ were associated with 28-day mortality. IL-8 provided the best discrimination of mortality, and over time, non-survivors had increasing IL-6, IL-8, and IL-17A levels, in contrast to survivors (Kaewarpai et al, 2020 ; Wright et al, 2021 ). Similarly, Sengygee and coworkers correlated patient survival with high IFN-γ responses (Sengyee et al, 2021 ).…”
Section: Discussionmentioning
confidence: 99%
“…Twenty-three healthy individuals aged ≥ 18 years were recruited from Udon Thani Hospital and Mukdahan hospital as baseline controls for discovery and validation data sets. Inclusion and exclusion criteria for these controls were previously described [ 15 ].…”
Section: Methodsmentioning
confidence: 99%
“…Our prognostic signature indicates that lower glutamate levels are associated with fatal melioidosis, a finding that is consistent with previous reports of reduced glutamate levels in nonsurvivors of severe sepsis and its potential utility as an early biomarker for death in septic shock ( 46 ). Although promising, this prognostic signature requires further investigation in an independent cohort of patients with melioidosis and comparison to other predictive biomarkers and clinical tools ( 9 , 15 , 47 49 ).…”
Section: Discussionmentioning
confidence: 99%
“…Subjects at least 18 years of age admitted to Sunpasitthiprasong Hospital in Ubon Ratchathani, Thailand with suspected community-acquired infection were sequentially and prospectively enrolled within 24 hours of admission into the Ubon-Sepsis parent study from 2013 through 2017. This cohort has been described previously ( 9 15 ). Plasma samples were obtained from all participants at the time of enrollment.…”
Section: Methodsmentioning
confidence: 99%