A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile

Torres-Pérez, Fernando; Palma, R. Eduardo; Boric-Bargetto, Dusan; Vial, Cecilia; Ferrés, Marcela; Víal, Pablo A.; Martínez-Valdebenito, Constanza; Pavletic, Carlos; Parra, Alonso; Marquet, Pablo A.; Mertz, Grégory

doi:10.3390/v11090848

Cited by 7 publications

(5 citation statements)

References 99 publications

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“…A study conducted in Chile [ 46 ], during 19 years of sampling eleven rodent species, evaluated how ecology and geography influence host and viral dynamics in areas associated with HI cases in that country, finding that the main ANDV reservoir is O. longicaudatus with an intraspecific seroprevalence of 6.5%. They also point out the need for research on rodents’ social and behavioral interactions, highlighting the integration of ecological understanding of the host and pathogens, spatial and temporal surveillance, epidemiology, and public health agencies, as fundamental to understanding the transmission of the virus to humans.…”

Section: Discussionmentioning

confidence: 99%

Mathematical Model of the Spread of Hantavirus Infection

Gutiérrez-Jara,

Muñoz-Quezada,

Córdova-Lepe

et al. 2023

Pathogens

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A mathematical epidemiological model incorporating the mobility of rodents and human groups among zones of less or major contact between them is presented. The hantavirus infection dynamics is expressed using a model type SEIR (Susceptible-Exposed-Infectious-Removed), which incorporates the displacement of the rodent and the human, between the urban and rural sector, the latter being subdivided in populated and non-populated. The results show the impact that rodent or human displacement may have on the propagation of hantavirus infection. Human mobility is more significant than rodents in increasing the number of hantavirus infection cases. The results found may be used as a reference by the health authorities to develop more specific campaigns on the territorial dynamics of the rodent, attend to the mobility of humans in these territories, mainly agricultural and forestry workers, and strengthen control-prevention actions in the community, to prevent future outbreaks that are fatal.

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Section: Discussionmentioning

confidence: 99%

Mathematical Model of the Spread of Hantavirus Infection

Gutiérrez-Jara,

Muñoz-Quezada,

Córdova-Lepe

et al. 2023

Pathogens

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“…These include but are not limited to Andes virus ( Orthohantavirus andesense , ANDV) from Oligoryzomys longicaudatus ; Black Creek Canal virus ( Orthohantavirus nigrorivense , BCCV) from Sigmodon hispidus ; New York virus (NYV) from Peromyscus leucopus ; Choclo virus ( Orthohantavirus chocloense , CHOV) and Maporal Virus ( Orthohantavirus maporalense , MAPV) from Oligoryzomys fulvescens ; Rio Mamore virus (RIOMV) from Oligoryzomys microtis ; Bayou virus (BAYV) from Oryzomys palustris ; Laguna Negra virus ( Orthohantavirus negraense , LANV) from Calomys laucha ; and Juquitiba virus (JUQV) from Oligoryzomys nigripes [ 5 , 11 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. In South America, clinical cases of HCPS have been reported in Argentina [ 24 ], Uruguay [ 25 ], Brazil [ 26 ], Chile [ 27 , 28 ], Bolivia [ 29 ], Peru [ 30 , 31 ], and Paraguay [ 32 ]. In Brazil, JUQV and Araraquara virus (ARAV, reservoir: Necromys lasiurus) are the two strains that have been discovered in patients [ 33 ], and about 85% of HCPS cases reported in Brazil have occurred in a region where O. nigripes , the reservoir of JUQV, is endemic [ 26 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Deep Sequencing to Reveal Phylo-Geographic Relationships of Juquitiba Virus in Paraguay

Nnamani,

Spruill-Harrell,

Williams

et al. 2023

Viruses

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Several hantaviruses result in zoonotic infections of significant public health concern, causing hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS) in the Old and New World, respectively. Given a 35% case fatality rate, disease-causing New World hantaviruses require a greater understanding of their biology, genetic diversity, and geographical distribution. Juquitiba hantaviruses have been identified in Oligoryzomys nigripes in Brazil, Paraguay, and Uruguay. Brazil has reported the most HCPS cases associated with this virus. We used a multiplexed, amplicon-based PCR strategy to screen and deep-sequence the virus harbored within lung tissues collected from Oligoryzomys species during rodent field collections in southern (Itapúa) and western (Boquerón) Paraguay. No Juquitiba-like hantaviruses were identified in Boquerón. Herein, we report the full-length S and M segments of the Juquitiba hantaviruses identified in Paraguay from O. nigripes. We also report the phylogenetic relationships of the Juquitiba hantaviruses in rodents collected from Itapúa with those previously collected in Canindeyú. We showed, using the TN93 nucleotide substitution model, the coalescent (constant-size) population tree model, and Bayesian inference implemented in the Bayesian evolutionary analysis by sampling trees (BEAST) framework, that the Juquitiba virus lineage in Itapúa is distinct from that in Canindeyú. Our spatiotemporal analysis showed significantly different time to the most recent ancestor (TMRA) estimates between the M and S segments, but a common geographic origin. Our estimates suggest the additional geographic diversity of the Juquitiba virus within the Interior Atlantic Forest and highlight the need for more extensive sampling across this biome.

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“…The collaboration [ 80 ] resulted in >11,000 archived specimens over 2 decades, which now serve as a foundation for continued monitoring of and research into hantaviruses and their hosts, in addition to other symbionts and pathogens. Similar responses to HPS emergence in Chile and Argentina spawned parallel specimen-based research efforts that identified new hantavirus strains in a number of rodent species [ 81 – 83 ], underscoring the power of public health–biorepository collaborations to build comprehensive biological archives useful for EID research and response. Fundação Oswaldo Cruz (Fiocruz, Brazil) provides another precedent of successful biorepository and public health integration to maximize EID research and response.…”

Section: Introductionmentioning

confidence: 99%

Leveraging natural history biorepositories as a global, decentralized, pathogen surveillance network

et al. 2021

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The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic reveals a major gap in global biosecurity infrastructure: a lack of publicly available biological samples representative across space, time, and taxonomic diversity. The shortfall, in this case for vertebrates, prevents accurate and rapid identification and monitoring of emerging pathogens and their reservoir host(s) and precludes extended investigation of ecological, evolutionary, and environmental associations that lead to human infection or spillover. Natural history museum biorepositories form the backbone of a critically needed, decentralized, global network for zoonotic pathogen surveillance, yet this infrastructure remains marginally developed, underutilized, underfunded, and disconnected from public health initiatives. Proactive detection and mitigation for emerging infectious diseases (EIDs) requires expanded biodiversity infrastructure and training (particularly in biodiverse and lower income countries) and new communication pipelines that connect biorepositories and biomedical communities. To this end, we highlight a novel adaptation of Project ECHO’s virtual community of practice model: Museums and Emerging Pathogens in the Americas (MEPA). MEPA is a virtual network aimed at fostering communication, coordination, and collaborative problem-solving among pathogen researchers, public health officials, and biorepositories in the Americas. MEPA now acts as a model of effective international, interdisciplinary collaboration that can and should be replicated in other biodiversity hotspots. We encourage deposition of wildlife specimens and associated data with public biorepositories, regardless of original collection purpose, and urge biorepositories to embrace new specimen sources, types, and uses to maximize strategic growth and utility for EID research. Taxonomically, geographically, and temporally deep biorepository archives serve as the foundation of a proactive and increasingly predictive approach to zoonotic spillover, risk assessment, and threat mitigation.

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A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile

Cited by 7 publications

References 99 publications

Mathematical Model of the Spread of Hantavirus Infection

Mathematical Model of the Spread of Hantavirus Infection

Deep Sequencing to Reveal Phylo-Geographic Relationships of Juquitiba Virus in Paraguay

Leveraging natural history biorepositories as a global, decentralized, pathogen surveillance network

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