A 16-Year Prospective Study of Prodromal Features Prior to BPI Onset in Well Amish Children

Instruments that prospectively predict bipolar disorder – A systematic review

“…Such pathways may include follow-up studies of general population samples (Cannon et al, 2002), familial high risk samples (Duffy et al, 2009;Egeland et al, 2012), university student samples (Alloy et al, 2012;Kwapil et al, 2000) and clinical samples including baseline diagnoses such as depression, ADHD, anxiety, BPD etc. The variability may also be in the instruments utilized to assess phenomenological, diagnostic, temperamental, behavioral and even biological characteristics in the months and years preceding BD onset.…”

The Dutch Bipolar Offspring Study: 12-Year Follow-Up

“…At the young adult follow-up assessment 23 years later, 19% of the 32 bipolar offspring who were still in the study had developed bipolar disorder; of these, 6% were diagnosed with bipolar I disorder and 13% with bipolar II disorder. The second study is the bipolar offspring cohort from the Amish population followed by Egeland et al for 16 years (14,15). This sample included 115 bipolar offspring (ranging from age 13 to beyond age 30) from 15 families with a parent with bipolar I disorder and focused on prodromal symptoms of bipolar I disorder.…”

The Affective and Emotional Composite Temperament Scale (AFECTS): Psychometric properties of the Spanish version in a community sample from Mexico City and comparison between remitted psychiatric patients

“…In the AFECT model, the sensitivity dimension reflects how someone usually reacts to common stressors, such as interpersonal events (rejection, criticism, offense) or general situations (frustration, pressure, trauma, and loss) . Sensitivity by nature, and not "episodic" sensitivity, has been described as a possible early marker of vulnerability for a bipolar disorder, and is associated with anxiety/worry and depressive symptoms in well youngsters followed for 16 years (Egeland et al, 2012). Interpersonal sensitivity has been reported in bipolar disorder patients (Fletcher et al, 2012).…”