A 16-year Follow-up Case of Interstitial Pneumonia with Systemic Sclerosis-rheumatoid Arthritis Overlap Syndrome

Yamakawa, Hideaki; Hagiwara, Eri; Yamanaka, Yoshiaki; Ikeda, Satoshi; Sekine, Akimasa; Kitamura, Hideya; Baba, Tomohisa; Okihara, Koji; Iwasawa, Tae; Takemura, Tamiko; Ogura, Takashi

doi:10.2169/internalmedicine.56.7202

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…The time between diagnoses was 9.99 ±11.86 years. Early diagnosis of RA is often difficult in patients with SSc because arthritis may be present in both [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary manifestations are the leading cause of morbidity and mortality [ 8 ]. Interstitial lung disease occurs in up to 80% of SSc patients, making ILD more prevalent in SSc than in any other connective tissue disease [ 6 ]. The main risk factors for lung fibrosis are male sex, diffuse cutaneous SSc subtype, presence of anti-Scl-70 antibodies, forced vital capacity of < 70%, and extent of fibrosis at baseline [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Also, inflammatory small airway disease might be a secondary finding in RA [ 6 ]. In this case, our patient presented with pulmonary involvement of both diseases, fibrosis and bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

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Systemic sclerosis and rheumatoid arthritis overlap syndrome – management of severe cardiac, pulmonary and articular involvement

Pinto¹,

Santos²,

Dinis³

et al. 2023

Reumatologia

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IntroductionThe presence of another rheumatological condition in patients with systemic sclerosis (SSc) is not uncommon. To report a case of a patient with SSc-RA overlap and perform a review of the cases re-ported in the literature.Material and MethodsA chart review of the present case report was performed. After, we performed a literature search in MEDLINE, EMBASE and Cochrane databases.ResultsWe included 26 articles. Sixty-three patients were reviewed, 51 were female with a mean age of 45.03 years at the time of the first diagnosis. Sixty-three patients were diagnosed with limited cu-taneous SSc. Regarding organ involvement, the most frequently reported were cutaneous, vascular, pulmonary and gastrointestinal involvement. Erosions were presenting 65.08% of patients. A panoply of treatments was used.ConclusionsThe authors concluded that screening for an associated disease should be encouraged since the overlap with SSc may affect prognosis and treatment.

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“…The time between diagnoses was 9.99 ±11.86 years. Early diagnosis of RA is often difficult in patients with SSc because arthritis may be present in both [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Systemic sclerosis and rheumatoid arthritis overlap syndrome – management of severe cardiac, pulmonary and articular involvement

Pinto¹,

Santos²,

Dinis³

et al. 2023

Reumatologia

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show abstract

“…Only about 6% of patients with SSc overlap with RA (2) . Only quite a few cases have reported lung involvement during SSc-RA overlap (3,4) . Lung involvement as the first clinical manifestation of SSc-RA overlap is even rarely reported.…”

Section: Introductionmentioning

confidence: 99%

A rare case of Interstitial lung disease complicated by overlapping syndrome with obstructive ventilatory dysfunction as the first symptom

Liang

et al. 2021

MRHK

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Interstitial lung disease is often a serious complication of connective tissue disease（CTD）, representing the first cause of death in CTD. However, there are few reports of SSc-RA overlap-associated interstitial pneumonia. Respiratory dysfunction as the first clinical manifestation is even rarely reported. We herein described a case of a male patient who developed significant respiratory dysfunction as the principal clinical sign for the past 6 months, plus newly developed skin thickening in bilateral upper limbs and pain and swelling of multiple joints for the past 6 weeks. Extensive immunological screening showed high titer of antinuclear antibodies(ANA), rheumatoid factor(RF), anti-cyclic peptide containing citrulline (anti-CCP)，and positive anti-Scl-70 antibody. Chest high resolution computed tomography(HRCT) was performed and hence ILD was confirmed. Pulmonary function test (PFT) revealed obstructive ventilatory dysfunction rather than restrictive ventilatory dysfunction. So bronchodilation test was performed and asthma was considered. Finally, after a multidisciplinary team (MDT) discussion, the diagnosis of asthma and ILD associated with SSc-RA overlap was established. It is important to note that CTD associated pulmonary interstitial fibrosis must be considered as the differential diagnosis of any newly diagnosed interstitial pulmonary disease. In addition, if patient with dyspnea is highly suspicious of pulmonary interstitial fibrosis, bronchodilation test is still needed to exclude asthma in order to avoid misdiagnosis.

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A 16-year Follow-up Case of Interstitial Pneumonia with Systemic Sclerosis-rheumatoid Arthritis Overlap Syndrome

Cited by 2 publications

References 14 publications

Systemic sclerosis and rheumatoid arthritis overlap syndrome – management of severe cardiac, pulmonary and articular involvement

Systemic sclerosis and rheumatoid arthritis overlap syndrome – management of severe cardiac, pulmonary and articular involvement

A rare case of Interstitial lung disease complicated by overlapping syndrome with obstructive ventilatory dysfunction as the first symptom

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