A 16-Channel Patient-Specific Seizure Onset and Termination Detection SoC With Impedance-Adaptive Transcranial Electrical Stimulator

Silicon-Integrated High-Density Electrocortical Interfaces

“…As one of the treatments for epilepsy, functional neurostimulation in response to detected seizures has been proved effective in reduction of seizures [109], [110]. For real-time closed-loop therapeutics, online automated seizure prediction and/or detection based on ECoG or EEG recordings of epileptic patients is imperative [111]- [114], and their on-chip implementation has been actively investigated and demonstrated utilizing extraction and classification of various signal features such as power spectral densities and wavelet coefficients [47], [77], [115]- [118].…”

An Ultralow-Power Sleep Spindle Detection System on Chip

“…The contribution of the sleep spindle detection system to the equivalent input noise of the full EEG system (including an EEG amplifier) will be reduced as a function of the gain chosen for the amplifier stage. Hence, by considering a typical amplifier gain of 100 and noise performance of state-of-theart EEG amplifiers such as [26] and [27], the minimum input signal that the full system would be able to process will be in the order of 1 µV rms . During our measurement process the signals were pre-amplified with a gain of 100 and added to a 625 mV DC voltage prior to being passed to the chip.…”

A 14-ENOB Delta-Sigma-Based Readout Architecture for ECoG Recording Systems

“…A prime example are the implantable neural recording interfaces [2], which can facilitate a wide range of medical applications due to the integration of wireless telemetry [3], [4], multi-channel recording [5], [6], on-chip feature extractions [7], data compression [8], bio-impedance measurements [9] and closed-loop brain stimulation [10], [11].…”

“…However, the total common-mode rejection is limited by the capacitor matching accuracy, which is further deteriorated by the impedance unbalance between the sensing and reference terminals of the analog front-end [24], [25]. An alternative solution is to use an analog DC servo loop, which performs active high-pass filtering, at the cost of an integrator with a considerable time constant [9], [26]. The main disadvantage of these approaches is that the cut-off frequency of each recording channel is prone to different variations [4].…”