A 15‐Year‐Old Domestic Shorthair Cat

Use of the Cell‐Dyn 3500 to Predict Leukemic Cell Lineage in Peripheral Blood of Dogs and Cats

“…Until recently, peripheral blood samples were manually evaluated, and automated methods were not considered practical or dependable when applied to veterinary species. There is mounting evidence that the analysis of multidimensional light scatter data, beyond the 5‐part differential, can enhance morphologic observations and add information important for the identification and classification of hematologic disorders 3 12,35 …”

“…There is mounting evidence that the analysis of multidimensional light scatter data, beyond the 5-part differential, can enhance morphologic observations and add information important for the identification and classification of hematologic disorders. 3,12,35 For this study, we constructed a diagnostic algorithm based on output data from the CD3500 and assessed its diagnostic utility to predict the ontogeny of leukemic cells in canine and feline blood. Our results show that the collective properties of the nucleated cell populations in peripheral blood reflected the intrinsic morphologic characteristics of individual cells, whether the cells were normal or abnormal.…”