A 15.5-Year Follow-up Study of Stroke in a Japanese Provincial City

Nakayama, Takeo; Date, Chigusa; Yokoyama, Tetsuji; Yoshiike, Nobuo; Yamaguchi, Mitoshi; Tanaka, Heizo

doi:10.1161/01.str.28.1.45

Cited by 176 publications

(103 citation statements)

References 56 publications

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“…Also, in many epidemiological studies reported in the United States and other Western countries, cigarette smoking has been noted to be a major risk factor of CI (Salonen et al 1982;Abbott et al 1986). Some studies of Japanese, including the Nippon data, have also shown smoking to be a risk factor of CI (Nakayama et al 1997;Ueshima et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Using the differential diagnosis of carotid artery calcification described by Friedlander (1995), when there was a radiopaque nodular mass (or masses) independent of the hyoid bone adjacent to the risk factor for CI (Wolf et al 1988;Ueshima et al 2004). Although the sudden onset of CI is not simple and related with many factors (Nakayama et al 1997), the authors hypothesized that smoking may have a large influence on the prevalence of carotid artery calcification seen on panoramic dental radiographs.…”

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confidence: 99%

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Long-Term Cigarette Smoking Increases the Prevalence of Carotid Artery Calcification Seen on Panoramic Dental Radiographs in Male Patients

Kumagai

Yamagishi

Fukui

et al. 2007

Tohoku J. Exp. Med.

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Panoramic dental radiographs are commonly used in general dentistry and oral and maxillofacial surgery to examine upper and lower teeth, maxilla, mandible and the surroundings simultaneously. Carotid artery calcification, a specific indicator of atherosclerotic change of the carotid arteries, can be seen on the radiographs. Many studies have suggested that cigarette smoking is a risk factor of atherosclerotic change as well as cerebral infarction. We hypothesized that smoking could increase the prevalence of carotid artery calcification, and compared the radiographs of smokers and non-smokers aged 50 years and over: 146 male smokers, 165 male non-smokers, 42 female smokers and 422 female non-smokers. This is the first study to focus on carotid artery calcification seen on panoramic dental radiographs to show the connection between smoking and atherosclerotic change. In male patients, carotid artery calcification was seen in 18 (14.1%) of the smokers, and in 8 (4.8%) of the non-smokers, which clearly shows that male patients aged 50 years old or over are more likely to develop carotid artery calcification if they smoke. However, there is no significant difference between female smokers and female non-smokers in the same age group. Dentists are in a good position to find carotid artery calcification on radiographs. When this is found on a radiograph, the patient should be advised to stop smoking and be referred to a physician for further tests. Clinicians should be aware that this radiographic finding indicates the presence of atherosclerotic change of the carotid arteries. carotid artery calcification; panoramic dental radiograph; cerebral infarction; cigarette smoking; atherosclerosis

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Long-Term Cigarette Smoking Increases the Prevalence of Carotid Artery Calcification Seen on Panoramic Dental Radiographs in Male Patients

Kumagai

Yamagishi

Fukui

et al. 2007

Tohoku J. Exp. Med.

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“…4 Prevalence of risk factors for Japanese are different from those in Western countries, but the relationship of the risk factors to cardiovascular incidence and mortality appears essentially the same as those in Western countries. [5][6][7] However, since the Japanese data are mainly from small cohorts in rural populations, comprehensive analysis of the effect of risk factors on CVD mortality and mortality from all causes has not been reported from large Japanese populations.…”

Section: Introductionmentioning

confidence: 99%

Impact of elevated blood pressure on mortality from all causes, cardiovascular diseases, heart disease and stroke among Japanese: 14 year follow-up of randomly selected population from Japanese — Nippon data 80

2003

J Hum Hypertens

140

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“…15 Although previous studies had shown proteinuria as an independent predictor of stroke outcome in general population, none have examined the possible association between microalbuminuria and incident of stroke. 16,17 Microalbuminuria is independently associated with carotid artery intima-media thickness in non-DM individual in insulin resistance and atherosclerosis study, USA. 18 The Epic Norfolk study is the 1st report evaluating the prospective relationship between microalbumin and fatal and non-fatal cerebrovascular accidents in general population.…”

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confidence: 99%

A prospective study on urinary microalbuminuria as surrogate marker of vascular endothelial dysfunction, in patients of ischemic stroke

2017

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Background: Presence of overt proteinuria has been independently linked to greater stroke risk. The objectives of this study were to determine the relationship between the for ischemic stroke and albuminurea as a marker for vascular events. Microalbuminuria, is an early marker of both kidney disease and endothelial dysfunction, may be associated with global vascular risk, but the nature and relationship between microalbuminuria and incident ischemic stroke has not been clearly defined. The purpose of this study was to assess the association of microalbuminuria and ischemic stroke.Methods: Study enrolled 150 admitted patients of acute ischemic stroke. The patients were assessed by questionnaire, microalbuminuria, creatinine clearance after detailed history taking and thorough clinical examination.Results: The combined common risk factors were HTN (80%), diabetes (33%) and smoking (53%). The hypertensive patients had 8 times higher risk of microalbuminuria as compared to normotensive patients (95% 1.8-31.0 p<0.05). Among diabetes patients had risk of microalbuminuria 30 times higher compared to euglycemic patients (95% CL 9.6-78.8 p<0.01). The smoker patients had 8 times risk of microalbuminuria (CL 95%-1.2-22.8 p<0.16). However, the patients who had dyslipidemia had risk of microalbuminuria 1.07 times who have normal lipid level, but it was statistically insignificance (98% CL 0.8-4.1 p>0.05). The 38 patients out of 46 patients who had microalbuminuria has high normal serum creatinine with creatinine clearance (45-59 mL/min/1.73 m2. (82% versus. 4.4% 30.44 mL/min/173m2). The risk of microalbuminuria was higher in patients who had high normal serum creatinine (1.4 mg/dL) with creatinine clearance of 45-59 mL/min/1.73 m2 versus normal serum creatinine 0.8 mg/dL.Conclusions: The finding of the study, show the microalbuminuria is an independent risk factor for vascular endothelial dysfunction, in patient of diabetes early renal dysfunction and HTN, extrapolating the vascular event (ischemic stroke).

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A 15.5-Year Follow-up Study of Stroke in a Japanese Provincial City

Cited by 176 publications

References 56 publications

Long-Term Cigarette Smoking Increases the Prevalence of Carotid Artery Calcification Seen on Panoramic Dental Radiographs in Male Patients

Long-Term Cigarette Smoking Increases the Prevalence of Carotid Artery Calcification Seen on Panoramic Dental Radiographs in Male Patients

Impact of elevated blood pressure on mortality from all causes, cardiovascular diseases, heart disease and stroke among Japanese: 14 year follow-up of randomly selected population from Japanese — Nippon data 80

A prospective study on urinary microalbuminuria as surrogate marker of vascular endothelial dysfunction, in patients of ischemic stroke

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