A 12-week double-blind randomized clinical trial of vitamin D3supplementation on body fat mass in healthy overweight and obese women

Abstract

BackgroundVitamin D concentrations are linked to body composition indices, particularly body fat mass. Relationships between hypovitaminosis D and obesity, described by both BMI and waist circumference, have been mentioned. We have investigated the effect of a 12-week vitamin D3 supplementation on anthropometric indices in healthy overweight and obese women.MethodsIn a double-blind, randomized, placebo-controlled, parallel-group trial, seventy-seven participants (age 38±8.1 years, BMI 29.8±4.1 kg/m2) were randomly allocated into two groups: vitamin D (25 μg per day as cholecalciferol) and placebo (25 μg per day as lactose) for 12 weeks. Body weight, height, waist, hip, fat mass, 25(OH) D, iPTH, and dietary intakes were measured before and after the intervention.ResultsSerum 25(OH)D significantly increased in the vitamin D group compared to the placebo group (38.2±32.7 nmol/L vs. 4.6±14.8 nmol/L; P<0.001) and serum iPTH concentrations were decreased by vitamin D3 supplementation (-0.26±0.57 pmol/L vs. 0.27±0.56 pmol/L; P<0.001). Supplementation with vitamin D3 caused a statistically significant decrease in body fat mass in the vitamin D group compared to the placebo group (-2.7±2.1 kg vs. -0.47±2.1 kg; P<0.001). However, body weight and waist circumference did not change significantly in both groups. A significant reverse correlation between changes in serum 25(OH) D concentrations and body fat mass was observed (r = -0.319, P = 0.005).ConclusionAmong healthy overweight and obese women, increasing 25(OH) D concentrations by vitamin D3 supplementation led to body fat mass reduction.This trial is registered at clinicaltrials.gov as NCT01344161.

Therapeutic impact of cholecalciferol in patients with psychiatric disorders receiving olanzapine

“…The effects of vitamin D3 on the reduction of waist circumference is also reported in a study by Salehpour et al (5). In addition, other studies such as Tamer et al have found that waist circumference and waist-hip ratio have a negative relationship with the serum level of vitamin D3 (12).…”

Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials

“…25,26 Choice of adiposity measures may be important in the evaluation of relationships between vitamin D supplementation and adiposity. 27 Only a few trials of vitamin D have assessed changes in body composition or in visceral or other fat depots, as directly measured by DXA, 23,28,29 magnetic resonance imaging (MRI), or computed tomography (CT). 30,31 DXA provides measures of overall adiposity, lean tissue, and regional distributions, with good reproducibility and minimal radiation exposure.…”

Vitamin D status by sociodemographic factors and body mass index in Mexican women at reproductive age

“…3,[11][12][13][14][15][16] It is not clear whether the VDD is produced by obesity or obesity is a consequence of VDD, 17 because obese individuals specially women, 18 are susceptible to VDD due to diminished availability of VD stored in the adipose tissue, and on the other hand, 18 some studies in obese individuals suggest that the supplementation with VD reduces the body fat mass. [19][20][21] Women at reproductive age are a group that can be intervened at earlier age for VDD and its long term complications.VDD during adulthood increases the risk of osteopenia, osteoporosis, muscle weakness, osteomalasia and pathological fractures and can worsen other chronic conditions, such as the polycystic ovary syndrome; it also is a risk factor for cardiovascular diseases, metabolic syndrome, some types of cancer and some autoimmune diseases. [16][17][18][19][20][21][22][23][24] This study aims to describe the prevalence of VDD and VDI, and the dietary sources of VD, in a probabilistic sample of women at reproductive age participating in Ensanut-2012, stratified by sociodemographic factors and BMI categories.…”

“…[19][20][21] Women at reproductive age are a group that can be intervened at earlier age for VDD and its long term complications.VDD during adulthood increases the risk of osteopenia, osteoporosis, muscle weakness, osteomalasia and pathological fractures and can worsen other chronic conditions, such as the polycystic ovary syndrome; it also is a risk factor for cardiovascular diseases, metabolic syndrome, some types of cancer and some autoimmune diseases. [16][17][18][19][20][21][22][23][24] This study aims to describe the prevalence of VDD and VDI, and the dietary sources of VD, in a probabilistic sample of women at reproductive age participating in Ensanut-2012, stratified by sociodemographic factors and BMI categories.…”