A 10-year survey of large bowel carcinoma at Groote Schuur Hospital with particular reference to patients under 30 years of age

Elloit, M. S.; Louw, J.H.

doi:10.1002/bjs.1800660907

Cited by 19 publications

(5 citation statements)

References 22 publications

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“…Out of 18 patients diagnosed before they were 45, only six survived for over seven years, thus supporting the belief that young patients have a poor prognosis. 3 Distressingly, at the time of diagnosis half the patients (218) were either dead (10 cases) or already incurable by present methods (table IV; fig 1). These included 38 who were unfit for any operation, 69 (16% of all patients in the series) whose tumours were irremovable, and 101 (23% of the whole series) who underwent palliative resection.…”

Section: Discussionmentioning

confidence: 79%

Outcome in colorectal carcinoma: seven-year study of a population.

Clarke¹,

Jones²,

Needham³

1980

BMJ

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Section: Discussionmentioning

confidence: 79%

Outcome in colorectal carcinoma: seven-year study of a population.

Clarke¹,

Jones²,

Needham³

1980

BMJ

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“…In our series, survival worsens progressively with age. The poor prognosis frequently reported in young patients mainly applies to those less than 25 or 30 years of age [18,19]. Women had significantly better survival prospects than men (p = 0.02).…”

Section: Discussionmentioning

confidence: 99%

Carcinoma of the colon: Long‐term survival and prognosis after surgical treatment in a series of 798 patients

Moreaux¹,

Catalá²

1987

World j. surg.

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From 1964 to 1985, a total of 798 patients (405 female, 393 male) were operated on for a single cancer of the colon. Fifty-eight percent of the patients were between 60 and 80 years of age. Liver and/or peritoneal metastases were present in 16.3% of the 818 cases. Resection was performed in 754 cases (92.2%), and was considered to be curative in 646 (78.9%). Tumors were differentiated in 90.5% of the cases. Regional lymph nodes were involved in 33.3% and serosal penetration was present in 19.5% of the cases. There were 7 postoperative deaths, 3 (0.5%) of them after curative resection. The actuarial curves of survival showed a probability of survival after all operations of 62% at 5 years and 46% at 10 years, and after curative resection of 78% at 5 years and 58% at 10 years. Prognosis has been established from the 513 patients operated on before 1980; follow-up data were available for all but 4 of them. Tumor site in the right or left colon did not relate significantly to survival. Tumor staging was the main prognostic factor. The 5-year survival rate was 40% in patients with positive nodes, 74.7% in those with negative nodes (p < 0.001), 97.6% in those with invasion limited to mucosa or submucosa, and 41.9% in those with serosal invasion (p < 0.001). Based on Dukes' classification, the 5-year survival rates for A, B, C, and D tumors were 9i%, 76.7% (p = 0.01), 53.1% (p < 0.001), and 4.7% (p < 0.001), respectively. Time elapsed between first symptom and operation did not relate significantly to survival. Prognosis was better in patients less than 50 years old when compared with patients 50-70 years of age (p < 0.01), and was better in female patients than in male patients (p = 0.02).In France, approximately 25,000 new cases of colorectal cancer are diagnosed each year and the mortality rate attributed to carcinoma of the large intestine, in 1981, was 11.6% of the total cancer mortality rate [1].The purpose of the this article is to report on survival in a series of 798 patients with single carcinoma of the colon operated on by one senior surgeon and one junior surgeon, in the same hospital, with the same surgical techniques and methods of pre-and postoperative management, and followed up over the same period of time.

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“…Another hypothesis is related to tumor heterogeneity and assumes the predominance of low-maturity cell clones at the time of intense tumor infiltration and spread. Older studies (Eker [19] and Elliot and Louw [20]) described a significantly higher incidence of low-maturity neoplasms in patients under 30 years of age. Lawday et al [8] noted a significant predilection of highly differentiated rectal carcinomas to localization in its upper part.…”

Section: Discussionmentioning

confidence: 99%

Five-year follow-up study of stage I-IV rectal cancer including EGFR immunoexpression and p21 immunoactivity

Kozłowska-Geller¹,

Głuszek²,

Lewitowicz³

2021

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Introduction: Both environmental and genetic factors increase the likelihood of developing rectal cancer. Aim: To assess the EGFR and p21 immunoreactivity in rectal cancer and to assess its relationship with the clinical outcome. Material and methods: Applying exclusion criteria, 102 patients with stage I-IV rectal cancer, who had undergone scheduled surgery during the period 2005-2011, were included in the study. There was a follow-up study with a span of 5 years from the date of the surgery. Immunohistochemistry using epidermal growth factor receptor (EGFR Ab10, Clone111.6) and antibodies against p21 (p21 WAF1 (Clone H252)) was performed to detect overexpression of the targeted receptor. Digital analysis of positive reactions of membranes and nuclei was performed utilizing Visiopharm.Results: The degree of EGFR intensity (log OR = 0.854, OR = 2.35, 95% CI: 1.14-4.85, p = 0.021) is a significant factor in the prognosis of death within 2 years after surgery. The OS curve showed a significant decrease after 40 months from the date of surgery in the cases where EGFR had high expression. The ROC curve for cancer stage, according to the UICC classification and EGFR expression, in order to predict 2-year RFS, reached a high specificity value (ROC = 0.81, p = 0.0408). The analysis showed no statistically significant differences in the survival curves of patients in groups with immunoreactivity of p21 protein at 0, 1, 2, 3 (p = 0.6453 in the log-rank test). Also, it is not a significant risk factor for death (HR = 0.915, p = 0.7842) or for tumor dissemination (HR = 0.94, p = 0.9426).Conclusions: The determination of EGFR immunoreactivity is important in the monitoring and treatment of patients with rectal cancer, as opposed to p21.

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A 10-year survey of large bowel carcinoma at Groote Schuur Hospital with particular reference to patients under 30 years of age

Cited by 19 publications

References 22 publications

Outcome in colorectal carcinoma: seven-year study of a population.

Outcome in colorectal carcinoma: seven-year study of a population.

Carcinoma of the colon: Long‐term survival and prognosis after surgical treatment in a series of 798 patients

Five-year follow-up study of stage I-IV rectal cancer including EGFR immunoexpression and p21 immunoactivity

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