A 10-Year Review of Penetrating Keratoplasty

Inoue, Kenji; Amano, Shiro; Oshika, Tetsuro; Sawa, Mitsuru; Tsuru, Tadahiko

doi:10.1016/s0021-5155(99)00190-2

Cited by 68 publications

(45 citation statements)

References 11 publications

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“…The 5-year Kaplan-Meier survival rate in the present series of 97.6% is comparable to those of other series. (24,25) Age, gender, and recipient size did not contribute to an increased risk of graft failure after PKP in the present study's patients.…”

Section: Discussionmentioning

confidence: 43%

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Penetrating Keratoplasty for Keratoconus : Visual and Graft Survival Outcomes

Al-Mohaimeed¹

2013

IJHS

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Objectives: To evaluate the complications, and visual and graft survival outcomes in eyes that had undergone penetrating keratoplasty (PKP) for keratoconus. Methodology: This restrospective study includes 311 patients with keratoconus who had undergone PKP between January 1, 2001, and December 31, 2002, at King Khaled Eye Specialist Hospital. All patients were followed up postoperatively (maximum follow-up, 65.77 months). Results:The mean age of patients with keratoconus at transplantation was 23.72 years. A preoperative best spectaclecorrected visual acuity (BSCVA) OF 20/40 or better was achieved in 13 eyes (4.2%). At a mean follow-up of 27 months, 212 eyes (68.2%) achieved a BSCVA of 20/40 or better. Postoperative visual acuity was significantly associated with preoperative visual acuity (P < 0.00). Only 6 eyes (1.9%) experienced graft failure, with a mean follow-up of 23.62 months. The graft rejection rate (6.8%) was a significant risk factor for failure (P = 0.00). Age, gender, corneal graft diameter, and intraoperative vitreous loss had no statistically significant effects on the PKP outcome (P> 0.05). Kaplan-Meier analysis revealed that the probabilities of graft survival were 99.8% at 1 year and 97.6% at 5 years after transplantation. Conclusion: Performing PKP in eyes with keratoconus is associated with good visual results and an excellent graft outcome.

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Section: Discussionmentioning

confidence: 43%

“…In the present study, 68.2% of patients achieved 20/40 or better following surgery, which compares favorably with rates of 47% to 91% reported in the literature. (22)(23)(24)(25)(26)(27)(28)(29)(30) Mahmood and Wagoner (22) found that 55 eyes (61.1%) achieved a BCVA of 20/40 or better, and…”

Section: Discussionmentioning

confidence: 99%

Penetrating Keratoplasty for Keratoconus : Visual and Graft Survival Outcomes

Al-Mohaimeed¹

2013

IJHS

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“…[1][2][3][4][5][6][7][8][9][10] An important trend associated with improvements in cataract surgery techniques and the introduction of intraocular lenses has been a decline in aphakic bullous keratopathy (ABK) and an increase in pseudophakic bullous keratopathy (PBK). 8,[11][12][13][14] After cataract surgery techniques evolved and phacoemulsification technology improved in the 1990s, pseudophakic corneal oedema rates have decreased.…”

Section: Trends In Corneal Transplant Surgerymentioning

confidence: 99%

“…8,[11][12][13][14] After cataract surgery techniques evolved and phacoemulsification technology improved in the 1990s, pseudophakic corneal oedema rates have decreased. [5][6][7][8]11,[14][15][16] Descemet stripping automated endothelial keratoplasty (DSAEK) is a significant change in the approach to corneal transplantation involving the transplantation of an endothelial cell layer (with a thin stromal layer) vs a full thickness corneal graft in PKP. DSAEK has rapidly replaced PKP as the preferred method of corneal transplantation in eyes with PBK and Fuchs' corneal dystrophy.…”

Section: Trends In Corneal Transplant Surgerymentioning

confidence: 99%

Management of patients with combined glaucoma and corneal transplant surgery

Banitt

Lee

2009

Eye

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Penetrating keratoplasty (PKP) is associated with an increased risk of secondary glaucoma. The development of glaucoma after PKP is an important risk factor for decreased corneal graft survival. The incidence of glaucoma after corneal transplant as well as the mechanism of developing increased intraocular pressure is reviewed in this paper. Treatments for post-PKP glaucoma include medications, laser, and surgery. The most frequent surgical glaucoma intervention is implantation of a glaucomadrainage device. Recent advances in corneal transplantation surgery may help to decrease corneal failure and the risk of developing post-keratoplasty glaucoma.

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“…Table 7 shows the outcome of keratoplasty based on published reports from both established and less developed economies. [50][51][52][53][54][55][56][57][58][59] Dandona and associates analysed 1-, 2-, and 5-year survival rates of 1725 corneal transplants performed at a tertiary eye care center in India. 58 The survival rates were 79.6% (95% CI 77.…”

Section: Outcome Of Penetrating Keratoplastymentioning

confidence: 99%

The value of corneal transplantation in reducing blindness

Garg

Krishna

Stratis

et al. 2005

Eye

122

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Purpose To analyse the role of keratoplasty in reducing world blindness due to corneal diseases. Methods Review of published literature. We collected and analysed articles published in the English language literature related to the prevalence and causes of blindness in different parts of the world, causes of corneal blindness, and outcome of corneal transplantation for various corneal diseases. Results A total of 80% of the world's blind live in developing countries. Retinal diseases are the most important causes of blindness (40-54%) in established economy nations while cataract (44-60%) and corneal diseases (8-25%) are the most common causes of blindness in countries with less developed economies. Keratitis during childhood, trauma, and keratitis during adulthood resulting in a vascularized corneal scar and adherent leucoma are the most frequent causes of corneal blindness in developing countries. Corneal diseases are responsible for 20% of childhood blindness. Nearly 80% of all corneal blindness is avoidable. The outcome of keratoplasty for vascularized corneal scar and adherent leucoma is unsatisfactory, necessitating repeat surgery in a high proportion of these cases. Other barriers for keratoplasty in these nations are suboptimal eye banking, lack of trained human resources, and infrastructure. Conclusions Since the developing world carries most of the load of corneal blindness and the major causes of corneal blindness are corneal scar and active keratitis, development of corneal transplantation services need a comprehensive approach encompassing medical standards in eye banking, training of cornea specialists and eye banking personnel and exposure of ophthalmologists to care of corneal transplants for better follow-up care. However, concerted efforts should be made to develop and implement prevention strategies since most corneal blindness is preventable.

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A 10-Year Review of Penetrating Keratoplasty

Cited by 68 publications

References 11 publications

Penetrating Keratoplasty for Keratoconus : Visual and Graft Survival Outcomes

Penetrating Keratoplasty for Keratoconus : Visual and Graft Survival Outcomes

Management of patients with combined glaucoma and corneal transplant surgery

The value of corneal transplantation in reducing blindness

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