A 10–year retrospective study of periodontal disease progression

Papapanou, Panos N.; Wennström, Jan L.; Gröndahl, Kerstin

doi:10.1111/j.1600-051x.1989.tb01668.x

Cited by 205 publications

(122 citation statements)

References 25 publications

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“…27-32 The close association between periodontal inflammation and ABL, as well as the rate of bone loss, has been well documented. 28,29 Studies 12 have also established a direct association between the severity of ABL and salivary levels of inflammatory markers. The conventional periodontal treatment stops further alveolar bone loss but does not result in bone gain.…”

Section: Commentmentioning

confidence: 98%

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Local Inflammation and Human Papillomavirus Status of Head and Neck Cancers

Tezal

Scannapieco²,

Wactawski‐Wende³

et al. 2012

Arch Otolaryngol Head Neck Surg

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Objective To determine whether periodontitis is associated with human papillomavirus (HPV) status of head and neck squamous cell carcinoma (HNSCC). Design and Setting Hospital-based case-control study in a comprehensive cancer center. Patients Evaluation included all patients diagnosed with incident primary squamous cell carcinoma of the oral cavity, oropharynx, and larynx between 1999 and 2007 for whom tissue samples and dental records were available (N = 124). Patients younger than 21 years and those with a history of cancer were excluded. Periodontitis history was assessed by alveolar bone loss in millimeters from panoramic radiographs by one examiner blinded to cancer status. Main Outcome Measure The presence of HPV-16 DNA in paraffin-embedded tumor samples was identified by polymerase chain reaction. Results The prevalence of HPV-positive HNSCC was 50 of 124 patients (40.3%). A higher proportion of oropharyngeal cancers were HPV-positive (32 of 49 [65.3%]) compared with oral cavity (9 of 31 [29.0%]) and laryngeal (9 of 44 [20.5%]) cancers. Each millimeter of alveolar bone loss was associated with 2.6 times increased odds (odds ratio [OR], 2.61; 95% CI, 1.58-4.30) of HPV-positive tumor status after adjustment for age at diagnosis, sex, and smoking status. The strength of the association was greater among patients with oropharyngeal SCC (OR, 11.70; 95% CI, 2.09-65.53) compared with those with oral cavity SCC (OR,2.32; 95% 0,0.65-8.27) and laryngeal SCC (OR, 3.89; 95% CI, 0.95-15.99). Conclusions A history of chronic inflammatory disease in the oral cavity may be associated with tumor HPV status in patients with HNSCC. This association seems to be stronger among palienLs with oropharyngeal cancer compared with those who have oral cavity or laryngeal SCC.

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Section: Commentmentioning

confidence: 98%

“…28,29 In this study, the radiographs were obtained at admission, documenting the history of periodontitis before cancer diagnosis. The normal ABL in healthy young adults is generally accepted to be 2 mm or less, 17 and the mean annual ABL varies between 0.07 and 0.14 mm.…”

Section: Commentmentioning

confidence: 99%

Local Inflammation and Human Papillomavirus Status of Head and Neck Cancers

Tezal

Scannapieco²,

Wactawski‐Wende³

et al. 2012

Arch Otolaryngol Head Neck Surg

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“…Considering that long exposure of IL-1 has been shown to inhibit, but short exposure stimulates, bone nodule formation (Ellies and Aubin, 1990), high levels of IL-113, which is continuously produced by PDL, may stimulate bone resorption and inhibit production by PDL on agarose-gel cells subjected to stretched (-) I'DL mechanical force in nplified for each vitro after the cells were obtained from young and old animals is also in progress. e studies on the age-related changes of periodontal destruction (Papapanou et al, 1989(Papapanou et al, , 1991Beck et al, 1990;Ismail et al, 1990;Haffajee et al, 1991;Machtei ct al., 1992), and they showed the positive relationship between age and periodontal destruction. Moreover, it is reported that the trauma of occlusion may enhance the rate of progression of plaque-associated periodontal disease (Lindhe, 1989).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that the severity of periodontal disease is affected by host age (Papapanou et al, 1989(Papapanou et al, , 1991Beck et al, 1990;Ismail et al, 1990;Haffajee et al, 1991;Machtei et al, 1992). However, the role of aging in the pathogenesis and aggravation of periodontal disease, and especially that attributable to trauma from occlusion, has not been wellcharacterized.…”

Section: Introductionmentioning

confidence: 96%

In vitro Cellular Aging Stimulates Interleukin-1β Production in Stretched Human Periodontal-ligament-derived Cells

Goseki¹,

Yamaguchi²,

Iwasawa³

et al. 1997

J Dent Res

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Although the severity of periodontal disease is known to be affected by host age, the pathological role of aging in periodontal disease, and especially that attributable to trauma from occlusion, has not been well-characterized. Interleukin (IL)-1 beta is a key mediator involved in periodontal diseases, a potent stimulator of bone resorption. Furthermore, it is produced by human periodontal ligament (PDL) cells in response to mechanical stress. To investigate the age-related changes in the biosynthetic capacity of IL-1 beta in PDL cells, we examined the effects of in vitro cellular aging with mechanical stress on IL-1 beta protein and gene expression by human PDL cells. Human PDL cells (young = 5th or 6th passage; old = 18-20th passage) were cultured on flexible-bottomed culture plates, and the cells were deformed at 6 cycles per min at 2 steps of tension force for 1 to 5 days. We found a two-fold increase in IL-1 beta production by old PDL cells subjected to mechanical tension compared with that by young PDL cells, although the constitutive levels of IL-1 beta were similar in both the young and old PDL cells. This increase was tension-dependent. IL- 1 beta mRNA was also detected in both cell types under basal conditions, and its expression was further enhanced by application of mechanical tension by use of reverse-transcription-polymerase chain-reaction (RT-PCR) and in situ hybridization methods. The increase in signal rate was higher in the old cells than in the young cells. IL-1 beta-converting enzyme mRNA remained unchanged. It is possible that a large amount of IL- 1 beta produced by PDL cells from an aged host in response to mechanical force may be positively related to the acceleration of alveolar bone resorption.

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“…Dans le sens horizontal, avec les défauts osseux larges ont tendance à une moins bonne cicatrisation après traitement en comparaison aux défauts étroits où le gain osseux peut être attendu avec une plus grande prévisibilité [37]. En l'absence de traitement, la persistance de défauts intra osseux va constituer un terrain favorable à la progression de la maladie et à la perte spontanée des dents [38]. Les lésions parodontales persistantes après traitement représentent un risque de récidive plus important par rapport à un défaut avec une architecture osseuse positive [39].…”

Section: Quantité Et Qualité Des Défauts Osseuxunclassified