A 10-year retrospective study of neonatal lupus erythematous in China

Yu, Yonghua; Du, Li-zhong; Pan, Jiarong; Zheng, Junhua; Chen, An; Chen, Lihua

doi:10.12932/ap0671.34.2.2016

Cited by 10 publications

(3 citation statements)

References 19 publications

(20 reference statements)

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“…It is usually associated with maternal SLE and other autoimmune diseases. (11,12) Multicenter studies performed in Brazil and the USA suggested that SLE in infants is usually associated with complement deficiencies. (13,14) Female children and adolescents develop SLE more commonly, possibly due to the hormonal changes of puberty.…”

Section: Epidemiologymentioning

confidence: 99%

Pediatric lupus nephritis

et al. 2019

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Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher morbidity and mortality rates. This narrative review aimed to describe the general aspects of LN and its particularities when affecting children and adolescents, while focusing on the disease's etiopathogenesis, clinical manifestations, renal tissue alterations, and treatment options.

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Section: Epidemiologymentioning

confidence: 99%

Pediatric lupus nephritis

et al. 2019

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“…The presence and titers of maternal anti-Ro/SSA antibodies gradually decreased after birth, they were found until 9 months old [ 24 ]. The autoantibodies transferred from mothers with ARD may induce various clinical manifestations of neonatal lupus, and these clinical findings seem to gradually improve up to 12 months of age, owing to the disappearance of maternal autoantibodies [ 24 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Catch-up growth of infants born to mothers with autoimmune rheumatic disorders

et al. 2022

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Background In women with autoimmune rheumatic disorders (ARD), pregnancy complications or postpartum events are more frequent compared to the general population. Transplacental autoantibodies or cytokines influence various fetal and neonatal outcomes. We compared the growth patterns of babies born to mothers with ARD versus healthy mothers to assess the long-term growth outcomes of children born to women with ARD. Methods This was a retrospective age-matched cohort analyses of babies born to mothers with ARD from the hospitals belonging to the Catholic University of Korea between 2010 and 2017. Demographic and autoimmune laboratory test data of the mothers and newborns were assessed. Neonatal growth was measured in terms of height and weight, measured at birth and follow-up examinations. Results We enrolled 142 infants from mothers with ARD and 149 infants from healthy mothers. There was no significant difference between mothers with ARD and healthy mothers in terms of delivery age, parity, abortion, and premature delivery history. The mothers with ARD were diagnosed with systemic lupus erythematosus (81%), Sjogren syndrome (6%), and other autoimmune phenomena (11%). The groups were significantly different in terms of neonatal characteristics such as prematurity, gestational age, birth weight, and height, but not in Apgar score and delivery type. For most neonates, autoimmune laboratory results were normalized within 1 year, except for anti-La/SSB antibody, which remained high in some. The height and weight for age z-score were lower than the normal age groups at birth but showed catch-up growth by 2 years of age. Conclusions Low birthweight and prematurity at birth for neonates born to mothers with ARD could be caught up by 2 years of age, and maternal ARD does not affect the growth of their offspring.

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“…In this study, 51.9%, 7.4%, and 3.7% of the mothers of infants with NLE had SLE, Sjögren’s syndrome, and mixed connective tissue disease before pregnancy, respectively. According to some reports, about 25–58% of the mothers of NLE patients were asymptomatic [ 1 , 24 , 25 , 26 ]. In our study, ten (37%) of the NLE mothers had not been diagnosed with any diseases before their infants were diagnosed with NLE, three (11.1%) of them were diagnosed with SLE and five (18.5%) of them had Sjögren’s syndrome after confirmation of their infants’ NLE, and two (7.4%) of them had not yet been diagnosed.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Lupus Erythematosus as a Rare Cause of Fever in Young Infants

Song

Park

Byun

et al. 2021

JCM

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Neonatal lupus erythematosus (NLE) is a rare disease caused by passively transmitted autoantibodies from the mother. NLE is a multi-organ system disease characterized by cutaneous, cardiac, hematological, hepatobiliary, and neurological manifestations. This study aimed to review the various symptoms and clinical manifestations in young infants with NLE and their mothers. We conducted a retrospective review of medical records of patients with NLE who were both examined and treated at Pusan National University Children’s Hospital between January 2009 and December 2020 and their mothers. Twenty-seven patients with NLE comprising 13 male patients (48.1%) and 14 female patients (51.9%) were included. The most common symptom was rash (40.7%), followed by fever (25.9%), arrhythmia (14.8%), splenomegaly (11.1%), and intrauterine growth retardation (7.4%). Seven patients with fever had various organ system manifestations, including cutaneous (100%), hematological (71.4%), hepatobiliary (57.1%), and central nervous system (CNS; 28.6%) manifestations. Two of the febrile patients had aseptic meningitis. Cutaneous, cardiac, hematological, hepatobiliary, and CNS involvement were noted in 44.4%, 18.5%, 51.9%, 40.7%, and 22.2% of the patients, respectively. Systemic lupus erythematosus (SLE) was the most common maternal disease (14/27, 51.9%). Ten mothers (37.0%) had not been diagnosed with any autoimmune disease until their babies were diagnosed. Among them, three were subsequently diagnosed with SLE, five were diagnosed with the Sjögren’s syndrome, and two of them still had no known diagnosis of any autoimmune disorder. Fever is a common symptom of NLE; thus, when there is no clear focus of fever in infants, NLE needs to be considered, especially in cases with skin rashes.

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A 10-year retrospective study of neonatal lupus erythematous in China

Cited by 10 publications

References 19 publications

Pediatric lupus nephritis

Pediatric lupus nephritis

Catch-up growth of infants born to mothers with autoimmune rheumatic disorders

Neonatal Lupus Erythematosus as a Rare Cause of Fever in Young Infants

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