A 10-Month-Old Infant Presenting With Signs of Precocious Puberty Secondary to a Sclerosing Stromal Tumor of the Ovary in the Absence of Hormonal Elevation

Squillaro, Anthony I.; Zhou, Shengmei; Schlüter, Thomas; Kim, Eugene

doi:10.1177/1093526618819605

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…However, in 1975, Damjanov et al reported the production of steroid hormones by SSTs [ 28 ]. Androgens and, less frequently, estrogens can lead to menstrual disturbances and signs of virilization or precocious puberty, as reported in several studies [ 8 , 12 , 21 , 25 , 26 , 27 , 29 , 30 , 31 , 32 , 33 , 34 ]. Menstrual irregularities are very common in the first two years after menarche; therefore, this symptom may be underestimated in this population or simply attributed to a physiologically abnormal hormonal production.…”

Section: Discussionmentioning

confidence: 90%

A Rare Ovarian Tumor: The Sclerosing Stromal You Do Not Expect—A Case Series in the Adolescent Population and a Literature Review

et al. 2023

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Sclerosing stromal tumor (SST) is a rare ovarian tumor arising from the sex cord-stromal cells that occurs mainly in young adults during the second and third decades of life and rarely in pediatric and adolescent populations. The objective of this study is to report three illustrative cases of SST in young girls who had undergone surgery at our clinic in or after 2009, and to perform a literature review of this rare ovarian tumor. A retrospective chart review of female patients aged <18 years with a diagnosis of SST treated in a tertiary pediatric hospital was performed. Furthermore, a 10-year review of the SST literature was completed. Three cases of SST at our institution were outlined. After reviewing the literature, 18 SST cases were identified. The mean age at diagnosis was 13.4 years, and the reported clinical presentations were abdominal or pelvic pain and menstrual irregularity. Seven patients had abnormal hormone tests or CA-125 levels. In approximately 30% of cases, conservative surgery was performed, preserving residual ovarian tissue. In conclusion, some preoperative findings may help in suggesting the presence of SST. However, definitive diagnosis can only be made by histopathological examination. It is important to consider this tumor because, given its benign behavior, a conservative approach is preferred, particularly in this age group.

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Section: Discussionmentioning

confidence: 90%

A Rare Ovarian Tumor: The Sclerosing Stromal You Do Not Expect—A Case Series in the Adolescent Population and a Literature Review

et al. 2023

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Sclerosing stromal tumor of the ovary: Two case reports and literature review

Tameish

2023

Clínica e Investigación en Ginecología y Obstetricia

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Nadir Görülen Bir Over Tümörü: Sklerozan Stromal Tümör

Hasdemir¹,

Atalay

Atalay³

2020

Uludağ Üniversitesi Tıp Fakültesi Dergisi

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Sklerozan stromal tümör (SST) over seks kord stromal tümörleri arasında yer alan oldukça nadir görülen benign bir stromal tümördür. Bu olgu sunumunda sağ overde SST saptanan hastanın, radyolojik bulguları ve histopatolojik özellikleri literatür eşliğinde kısaca tartışılmıştır. 23 yaşında kadın hasta, pelvik ağrı şikayeti ile başvurduğu dış merkezde yapılan abdominal ultrasonografisinde sağ adnekste kistik ve solid komponenti olan kitle lezyon saptanması üzerine ileri tanı ve tedavi için hastanemiz kadın doğum polikliniğine yönlendirildi. Cinsiyet değiştirme istemi de olan hastaya yapılan laboratuvar incelemelerinde herhangi bir hormonal anormallik saptanmadı. Kitlenin frozen incelemesi sonrasında total abdominal histerektomi ve bilateral salpingoooferektomi (TAH+BSO) yapılması kararlaştırıldı. Frozen kesitlerin incelenmesi sonucu "seks kord stromal tümör" olarak değerlendirilen tümörün mikroskopik incelemesinde, kollajenöz ve ödemli hiposellüler alanlar ile hipersellüler alanların oluşturduğu psödolobüler patern, belirgin vasküler proliferasyon izlendi. Morfolojik ve immunhistokimyasal bulgular ışığında sağ overde izlenen tümör "SST" olarak tanı almıştır. Sklerozan stromal tümör olgularının büyük bir kısmı vasküler açıdan zengin solid kitle olduğundan radyolojik olarak öncelikle malign tümör olasılığı akla gelmektedir. SST'nin benign biyolojik davranışa sahip olması ve konservatif cerrahinin gerekli olduğu genç hastalarda görülmesi nedeniyle intraoperatif patolojik tanısı oldukça önemlidir.

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A 10-Month-Old Infant Presenting With Signs of Precocious Puberty Secondary to a Sclerosing Stromal Tumor of the Ovary in the Absence of Hormonal Elevation

Cited by 3 publications

References 12 publications

A Rare Ovarian Tumor: The Sclerosing Stromal You Do Not Expect—A Case Series in the Adolescent Population and a Literature Review

A Rare Ovarian Tumor: The Sclerosing Stromal You Do Not Expect—A Case Series in the Adolescent Population and a Literature Review

Sclerosing stromal tumor of the ovary: Two case reports and literature review

Nadir Görülen Bir Over Tümörü: Sklerozan Stromal Tümör

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