A 10 minute approach for the phase specific synthesis of Se nanoparticles with tunable morphology: their anticancer efficacy and the role of an ionic liquid

Abstract

The current work demonstrates a rapid and highly facile controlled phase-specific synthesis of Se nanoparticles, their anticancer efficacy and the 3-in-1 role of a RTIL.

Size Tuning, Phase Stabilization, and Anticancer Efficacy of Amorphous Selenium Nanoparticles: Effect of Ion-Pair Interaction, −OH Functionalization, and Reuse of RTILs as Host Matrix

“…Notably, it has been reported that amorphous Se (α-Se) NPs exhibit greater anticancer efficacy than their crystalline counterparts. 11,21 However, α-Se is thermodynami-cally least stable and is prone to phase transformation to its crystalline forms (i.e., trigonal (t) and monoclinic (m) Se). 2,6,11,12 To utilize the full potential of Se NPs in the biomedical field, the synthesis protocols must facilitate fine control over the morphology as well as phase of the Se NPs.…”

“…11,21 However, α-Se is thermodynami-cally least stable and is prone to phase transformation to its crystalline forms (i.e., trigonal (t) and monoclinic (m) Se). 2,6,11,12 To utilize the full potential of Se NPs in the biomedical field, the synthesis protocols must facilitate fine control over the morphology as well as phase of the Se NPs. Various methodologies could be found in the literature regarding the synthesis of Se NPs.…”

Colloidal Nanospheres of Amorphous Selenium: Facile Synthesis, Size Control, and Optical Properties

“…The formation of a spherical shape was evident even at the beginning of the synthesis and elongation of reaction time did not compromise the morphology. Note that some of the particles appeared to be deviated from the spherical shape (Figure 1c–d) as a result of the deformation arising from the relatively low (31 °C) glass transition temperature of ɑ ‐Se [28] . Such a deformation might occur during sample preparation and/or under the irradiation of electron beam, specifically for those particles in physical contact.…”

Nontoxic photoluminescent tin oxide nanoparticles for cell imaging: deep eutectic solvent mediated synthesis, tuning and mechanism

“…62 Selenium nanoparticles (Se NPs) are known to be good antioxidant. Comparing the IC50 value of SnO 2 NPs with that of amorphous Se NPs 63 shows that the presently synthesized SnO 2 performs better. vs. OD of ABTS radical at 734nm…”