A 10% glycolic acid containing oil-in-water emulsion improves mild acne: a randomized double-blind placebo-controlled trial

Abels, Christoph; Kaszuba, Alexandra; Michalak, Iwonna; Werdier, D.; Knie, Ulrich; Kaszuba, Andrzej

doi:10.1111/j.1473-2165.2011.00572.x

Cited by 32 publications

(47 citation statements)

References 24 publications

(32 reference statements)

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“…Acidic detergents are favorable for maintaining a low SC pH . Moreover, mild acne is significantly improved after application of an acidic leave‐on product with pH 4 …”

Section: Ph and Antimicrobial Effectsmentioning

confidence: 99%

pH in nature, humans and skin

Proksch

2018

The Journal of Dermatology

377

273

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The pH plays an important physiological role in nature and humans. pH varies from 1 to 8 in human organs with tight regulation in blood and epithelia of barrier organs. The physiological pH of the stratum corneum is 4.1-5.8 and several mechanisms contribute to its formation: filaggrin degradation, fatty acid content, sodium-hydrogen exchanger (NHE1) activation and melanosome release. First, the acidic pH of the stratum corneum was considered to present an antimicrobial barrier preventing colonization (e.g. by Staphylococcus aureus and Malassezia). Later on, it was found that the pH influences skin barrier function, lipid synthesis and aggregation, epidermal differentiation and desquamation. Enzymes of ceramide metabolism (e.g. β-glucocerebrosidase or acid sphingomyelinase) as well as proteases (e.g. chymotryptic enzyme or cathepsin D linked to epidermal differentiation and desquamation) are regulated by the pH. Experimental disruption of the physical barrier leads to an increase of pH, returning to normal levels only after many hours. Inflammatory skin diseases and diseases with an involvement of the epidermis exhibit a disturbed skin barrier and an increased pH. This is known for atopic dermatitis, irritant contact dermatitis, ichthyosis, rosacea and acne, but also for aged and dry skin. Normalizing the pH by acidification through topical treatment helps to establish a physiological microbiota, to repair skin barrier, to induce epidermal differentiation and to reduce inflammation.

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“…Acidic detergents are favorable for maintaining a low SC pH . Moreover, mild acne is significantly improved after application of an acidic leave‐on product with pH 4 …”

Section: Ph and Antimicrobial Effectsmentioning

confidence: 99%

pH in nature, humans and skin

Proksch

2018

The Journal of Dermatology

377

273

View full text Add to dashboard Cite

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“…However, several studies (including a large multicentre, double‐blind, randomized, vehicle‐controlled trial) have demonstrated the safety and efficacy of a preparation containing a combination of the AHA glycolic acid and retinaldehyde (a form of vitamin A) in treating acne and post‐inflammatory hyperpigmentation associated with acne . Furthermore, a recent single‐centre, double‐blind, randomized, placebo‐controlled trial on 10% glycolic acid monotherapy for mild acne showed significant improvement in acne compared with the placebo after 90 days of treatment …”

Section: Alpha‐hydroxy Acidsmentioning

confidence: 99%

The role of topical dermocosmetics in acne vulgaris

Araviiskaia

Dréno²

2016

Acad Dermatol Venereol

106

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Acne is a common chronic inflammatory disease and treatment modalities based on acne severity are well established. The role of dermocosmetics in dermatology, and in particular acne, is becoming more important as more research elucidates the mechanisms of action of products in the pathogenesis of acne. Dermocosmetics have the potential to be used as monotherapy or in combination with medical treatment. Therefore, it has become important for dermatologists to understand dermocosmetics to effectively and appropriately advise patients on their use. The objective of this review was to provide new insights into the role of traditional and novel ingredients in dermocosmetics for the treatment of acne, based on the authors' objective assessment of the published literature. The type of products discussed include: those which have a sebostatic effect, such as topical antioxidants and niacinamide; agents targeting abnormal keratinization, such as salicylic acid, lipo-hydroxy acid, alpha-hydroxy acids, retinol-based products and linoleic acid; agents targeting Propionibacterium acnes, such as lauric acid; and anti-inflammatory agents such as nicotinamide, alpha-linolenic acid and zinc salts. Despite the scientific advances in understanding these cosmetic ingredients, there still remains a lack of rigorous controlled studies in this area.

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“…). The chemical peeling agents were as follows: salicylic acid 20–30%, glycolic acid 10–70%, Jessner solution, trichloroacetic acid (TCA) 25%, mandelic acid 10%, amino fruit acid 20–60% and lipo‐hydroxy acids 0.3–10% . The majority of the studies ( N = 8/11) compared two peeling agents to each other .…”

Section: Resultsmentioning

confidence: 99%

“…Strong evidence of efficacy was found on behalf of glycolic acid (10% and 40%). This was due to two randomized, double‐blinded, placebo‐controlled studies with high methodological quality . One study investigated the efficacy of lipo‐hydroxy acid (0.3%) compared to benzoyl peroxide, demonstrating no statistically significant results between the lipo‐hydroxy acid‐group and the benzoyl peroxide‐group.…”

Section: Resultsmentioning

confidence: 99%

The efficacy and safety of non‐pharmacological therapies for the treatment of acne vulgaris: A systematic review and best‐evidence synthesis

Vries

Meulendijks

Driessen

et al. 2018

Acad Dermatol Venereol

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Circumstantial evidence was found for non-pharmacological therapies in the treatment of acne vulgaris. However, the lack of high methodological quality among included studies prevented us to draw clear conclusions, regarding a stepwise approach. Nevertheless, our systematic review including a best-evidence synthesis did create order and structure in resulting outcomes in which a first step towards future research is generated.

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A 10% glycolic acid containing oil-in-water emulsion improves mild acne: a randomized double-blind placebo-controlled trial

Cited by 32 publications

References 24 publications

pH in nature, humans and skin

pH in nature, humans and skin

The role of topical dermocosmetics in acne vulgaris

The efficacy and safety of non‐pharmacological therapies for the treatment of acne vulgaris: A systematic review and best‐evidence synthesis

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