A 1,8-naphthalimide-based turn-on fluorescent probe for imaging Cu2+ in lysosomes

Li, Xiaohong; Yan, Jinlong; Zong, Haitao; Wu, Wei-Na; Wang, Yuan; Zhao, Xiao-Lei; Fan, Yun-Chang; Xu, Zheng

doi:10.1016/j.inoche.2021.109026

Cited by 8 publications

(1 citation statement)

References 38 publications

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“…Moreover, the low toxicity of the probe found its application in the bioimaging of the HeLa cells for monitoring Cu 2 + in lysosomes. [127] Nur et al (2022) designed and synthesized a 1,8-napthalimide-based fluorescent chemoprobe 85 for the detection of Cu 2 + ions in environmental samples. In the first step, 6-bromo-1,8-naphthalic anhydride (1) was reacted with n-butylamine under acidic conditions forming compound 41 which on further reaction with hydrazine at high temperature yielded compound 51 via nucleophilic substitution reaction.…”

Section: Detection Of Cu 2 + Ionsmentioning

confidence: 99%

1,8‐Naphthalimide‐Based Chemosensors: A Promising Strategy for Detection of Metal Ions in Environmental and Biological Systems

Kaur,

Singh,

Tandon

et al. 2023

ChemistrySelect

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The advancement of optical chemosensors has achieved success with the advent of Supramolecular Chemistry. Unlike other scaffolds, the 1,8‐naphthalimide motif has emerged as an excellent fluorescent chemosensor due to its photophysical properties like thermostability, cytotoxicity, membrane permeability, selectivity, and sensitivity. The naphthalimide scaffold is distinctive in its ways of tracking biological analytes and diagnosing its role in various diseases. This review provides insight into current developments in the synthesis and designing of 1,8‐naphthalimide‐based chemosensors for the recognition of metal ions, its mechanistic approach for its sensitivity, selectivity, and practical applications in a real environment. We hope that this review will aid to develop a novel approach to sense toxic analytes in real water samples and improve real‐time applications.

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Section: Detection Of Cu 2 + Ionsmentioning

confidence: 99%