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An LC-MS/MS method for determination of forsythiaside in rat plasma and application to a pharmacokinetic study

“…The content of forsythiaside is about 4-7% in its dry green fruits named Qing-Qiao and 0.8-3% in its ripe fruits named Lao-Qiao [3][4][5]. Pharmacological studies demonstrated that forsythiaside possesses strong antioxidant [8,9], antibacterial [8] and antiviral [10,11] activities, and also exhibits a slow relaxation effect against norepinephrine induced contraction of rat aorta [12]. Moreover, it is reported that forsythiaside could significantly protect DNA damage caused by hydroxyl radicals [13] and inhibit protein kinase C (PKC␣) with an IC 50 value of 1.9 M [14].…”

Compressive Deformation Behavior of the SiCw/AZ91 Composite at Elevated Temperatures

“…For AZ91 alloy, twins are formed when compressed to a small strain, which is similar to other Mg alloys during compression [5,6] . It is generally believed that whiskers impede the nucleation of twins [7] , so the addition of the whiskers changes the deformation mechanism of the composite in which twining takes place instead of the dislocations sliding at the initial stage of compression. Twining is an important model for the deformation of Mg alloy, which reorients the slip planes in order to relax stress concentrations and facilitates the slip of other planes.…”

Variable Separation Approach to Solve (2+1)-Dimensional Generalized Burgers System: Solitary Wave and Jacobi Periodic Wave Excitations

“…According to the variable separation procedure, [10] we first take the following Painlevé-Bäcklund transformation to u and w in Eqs. ( 4) and ( 5),…”