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doi:10.13040/ijpsr.0975-8232.11(12).6526-31

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Existing studies have been shown on anti-inflammatory and pharmacological properties of IBU and some of its derivatives by means of DFT and molecular docking tactics. The alteration of the propionic acid, aryl and/or the isobutyl moieties of ibuprofen has been observed to strengthen the anti-inflammatory, hepatotoxic and molecular properties of the drug candidates [ 20 ]. Also, one study was performed to evaluate in silico ibuprofen with potential anti-inflammatory activity via molecular docking with the COX-2 receptor (PDB ID: 4PH9 ) [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Modification of ibuprofen to improve the medicinal effect; structural, biological, and toxicological study

Rahman,

Afrin,

Zong

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Modification of ibuprofen to improve the medicinal effect; structural, biological, and toxicological study

Rahman,

Afrin,

Zong

et al. 2024

Heliyon

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Exploring ibuprofen derivatives as α‐glucosidase and lipoxygenase inhibitors: Cytotoxicity and in silico studies

Daud

Abid

Sardar

et al. 2022

Archiv der Pharmazie

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This study reports the synthesis of a series of ibuprofen derivatives, including thiosemicarbazides 4a-f, 1,3,4-oxadiazoles 5a-f, 1,3,4-thiadiazoles 6a-f, 1,2,4triazoles 7a-f, and their S-alkylated derivatives 8a-d. All of the newly synthesized derivatives were analyzed using 1 H NMR, 13 C NMR spectroscopy, and highresolution mass spectra (electron ionization) spectrometry. These synthetic molecules were examined for their in vitro baking yeast α-glucosidase and soybean 15-lipoxygenase (15-LOX) inhibition and cell viability studies. The results revealed that the compounds N-(3,4-dichlorophenyl)−5-[1-(4-isobutylphenyl)ethyl]-1,3,4oxadiazol-2-amine 5f (IC 50 3.05 ± 1.23 µM) and N-(3-fluorophenyl)-5-[1-(4isobutylphenyl)ethyl]-1,3,4-oxadiazol-2-amine 5b (IC 50 3.12 ± 1.21 µM) were the most potent with respect to the α-glucosidase enzyme while in case of 15-LOX, the compound 4-(2,4-dichlorophenyl)-1-[2-(4-isobutylphenyl)propanoyl]thiosemicarbazide 4e showed potent inhibition with an IC 50 value of 55.41 ± 0.41 µM. All these compounds were found least toxic by displaying a blood mononuclear cell viability value of 69.2%-97.8% by the MTT assay compared to the standards when assayed at 0.25 mM concentration. Molecular docking analyses were conducted to evaluate the inhibition profiles of these derivatives against the said enzymes and the data supported the in vitro profiles.

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Cited by 2 publications

References 22 publications

Modification of ibuprofen to improve the medicinal effect; structural, biological, and toxicological study

Modification of ibuprofen to improve the medicinal effect; structural, biological, and toxicological study

Exploring ibuprofen derivatives as α‐glucosidase and lipoxygenase inhibitors: Cytotoxicity and in silico studies

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