Abstract:Unmethylated CpG motifs frequently appear in bacterial DNA and induce immune responses through Toll-like receptor 9 (TLR 9) pathway. Noble class of suppressive oligodeoxynucleotide (suppressive ODN) inhibits the immune activation by CpG DNAs. Interleukin-12 (IL-12) has several biological activities and modulates inflammatory responses in the lungs. Objectives: The objective of this study was to show that bacterial DNA induces IL-12 expression through TLR 9 pathway in vivo. Methods: To test IL-12 production by … Show more
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