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Abstract

Curcuminoids are dietary phytochemicals obtained from dried rhizomes of turmeric plant (Curcuma longa). Curcuminoids are mixture of curcumin, demethoxy curcumin and bisdemethoxy curcumin in which curcumin is a major constituent. Several polymorphic forms of curcumin were reported. The present study relates to the preparation of different solid forms of curcuminoids and to study the influence of other constituents of curcuminoids on the polymorphic behaviour of curcumin. The developed solid forms were characterized by various spectral methods like Fourier Transform Infrared Spectroscopy (FTIR), Powder X-ray diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Scanning Electron microscopy (SEM). On crystallization from ethanol and upon melt crystallization, curcuminoids underwent transformation into an amorphous form. Grinding did not affect the polymorphic nature of curcuminoids. These findings suggest that curcuminoids undergo polymorphic modifications very similar to curcumin.

Solvate Formation of Bis(demethoxy)curcumin: Screening and Characterization

“…Curcuminoids, which can be found exclusively in the roots of turmeric spice Curcuma longa, possess various medicinal activities, such as anti-inflammatory, antioxidant, antiproliferative, antiangiogenic, and anticancer [9][10][11][12][13]. Commercially available curcuminoids consist of three main components: curcumin (CUR), demethoxycurcumin (DMC) and bis(demethoxy)curcumin (BDMC) [14][15][16]. The three components are structurally similar (Figure 1), which makes the separation and purification quite challenging [17,18].…”