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Pandey, Manoj; Thomas, Boben; Ramdas, Kunnambath; Eremenco, Sonya; Nair, Muralidharan

doi:10.1023/a:1015083713014

Cited by 38 publications

(12 citation statements)

References 9 publications

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“…Grade 3 and 2 acute skin toxicity was reported in 4.0% (4 patients) and 52.6% (50 patients) of cases. With a median follow-up of 16 months (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) any Grade >1 late toxicity was observed.…”

Section: Resultsmentioning

confidence: 99%

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Quality of Life in Early Breast Cancer Patients: A Prospective Observational Study Using the FACT-B Questionnaire

Ursini¹,

Nuzzo²,

Rosa³

et al. 2021

In Vivo

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Background/Aim: Quality of life (QoL) in early breast cancer (BC) treatment may be affected by acute and late toxicities. This study evaluated the impact of radiotherapy (RT) schedules, treatment-related toxicities, hormone therapy (HT) and age on QoL. Patients and Methods: Ninety-five patients answered the FACT-B 4.0 questionnaire. Acute or late toxicities were recorded at each follow-up visit. Results: The median trend of the QoL subscales was stable during all questionnaires. HT negatively impacted on Functional Assessment of Cancer Therapy-General-Total, functional and emotional wellbeing. No difference was recorded between RT schedules and toxicity. No significant differences for age were detected in QoL. Conclusion: RT seems not to influence QoL of BC patients, in terms of fractionation regimen or RT-related side-effects. Moreover, women having systemic HT experienced a QoL worse than patients treated with RT only. Further and longterm protocols are needed to improve the validity of the tool.Advances in diagnosis and treatment of breast cancer (BC) have led to an increase in cancer survival, resulting in quality of life (QoL) improvement. Breast conserving surgery followed by adjuvant radiation therapy (RT) is the current standard treatment for early BC. Local and systemic treatments could cause skin dyschromia, lymphedema, fatigue, hot flashes, sexual dysfunction, and arthralgia with consequent changes in physical appearance and routine activities. These toxicities may persist for a long time after treatment with a subsequent decline in QoL (1). Studies have shown that in clinical trials QoL represents an important endpoint, whose assessment could contribute to improved treatment and patient's satisfaction (2-5). Under this scenario, the main aim of the study was to evaluate the impact of RT and hormone therapy (HT) on the QoL during the first 2 years after RT. Fractionation schedules (conventional vs. hypofractionation), radiation toxicities and age were also investigated. QoL was evaluated with Functional Assessment of Chronic Illness Therapy General Questionnaire and its Breast Cancer Supplement (FACT-B) questionnaire (https://www.facit.org), version 4.0 in Italian language. This tool is deemed as a quick and well validated multi-dimensional self-report questionnaire with subscales measuring physical, social, emotional, and functional wellbeing and contains additional concerns in breast cancer (6). Patients and MethodsThe study was designed as a prospective observational research project and was approved by the Ethics Committee of the "SS Annunziata" Hospital, "G. D'Annunzio" University, Chieti, Italy on 9 th May 2018. All patients were treated in our Radiotherapy Department and provided written informed consent. Medical records of enrolled patients were marked by a pink circle to streamline the identification process during treatment and follow-up.Inclusion criteria were: female patients, age ≥18 years, histologically proven breast cancer, ductal carcinoma in situ and invasive carcinoma stage I-II, bre...

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Section: Resultsmentioning

confidence: 99%

“…The values for each question range from 0 (not at all) to 4 (very much). When single questions are skipped, scores are prorated using the average of the other answers in the scale and counted in the results (9). Final scores (FACT-B-Total) of all subscales range from 0 to 148, where 148 represents the most favorable score and accordingly a highest QoL.…”

mentioning

confidence: 99%

Quality of Life in Early Breast Cancer Patients: A Prospective Observational Study Using the FACT-B Questionnaire

Ursini¹,

Nuzzo²,

Rosa³

et al. 2021

In Vivo

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“…Most of studies exist regarding deterioration in QOL in breast cancer patients and its relationship with various sociodemographic variables are from the West, and very few are from India. [ 6 8 ] Therefore, this cross-sectional study was conducted on Indian women with breast cancer to assess the above-mentioned parameters.…”

Section: Discussionmentioning

confidence: 99%

Quality of life and its sociodemographic determinants in breast cancer patients

Gupta¹,

Surbhi²,

Brar³

et al. 2022

Ind Psychiatry J

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Background: Breast cancer is the most common cancer in women worldwide. As the outcome of any cancer treatment is not only dependent on disease-free interval but also on the quality of life (QOL) of the survivor. Hence, this study was conducted to evaluate QOL of breast cancer patients and sociodemographic factors affecting QOL of patients. Subjects and Methods: A cross-sectional study was conducted among 50 breast cancer patients and 50 controls, which fulfilled the selection criteria. The sociodemographic profile and QOL using the World Health Organization QOL-BREF were analyzed using the descriptive statistical methods. Results: All the QOL indicators were statistically significantly ( P = 0.0001) lower among breast cancer patients. QOL indicators were statistically significantly ( P < 0.01) lower in young age. Not much difference was observed according to religion and these were significantly ( P < 0.05) higher among the homemakers. There was no significant difference in all the QOL indicators according to the marital status of the cases. However, these were significantly ( P < 0.05) higher among rural cases compared with urban one. The QOL indicators were statistically significantly ( P < 0.05) higher among the cases living in joint families than nuclear. No difference was observed among different socioeconomic status. Conclusion: QOL was significantly lower among the breast cancer patients. Age, occupational status, type of family, and locality were the significant factors that affect the QOL of breast cancer patients. Hence, psychological and social support can play an important role in improving QOL of cancer patient.

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“…Each item is evaluated on a 5-point Likert-type scale from 0 (“not at all”) to 4 (“very much”). The overall score is the summary score of the subscales; the total score ranges from 0 to 144, and higher scores indicate better quality of life [ 22 , 23 ]. The Chinese version of the FACT-B has acceptable psychometric properties in Chinese patients with breast cancer [ 24 , 25 ].…”

Section: Methodsmentioning

confidence: 99%

Psychometric evaluation of the PROMIS social function short forms in Chinese patients with breast cancer

Cai

Huang

et al. 2021

Health Qual Life Outcomes

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Background The diagnosis of breast cancer and the subsequent treatment undermine patients’ participation in social activities. This study aimed to carry out a cross-cultural adaption and analysis of the construct validity and reliability of the Chinese version of the PROMIS social function short forms in patients with breast cancer. Methods This study utilized a cross-sectional research design, and was registered in the Chinese Clinical Trial Registry (ChiCTR2000035439). After a standardized cross-cultural adaption process, a psychometric evaluation was performed of the Chinese version of the PROMIS social function short forms. Using convenience sampling, eligible patients with breast cancer from tertiary hospitals in China were enrolled from January 2019 to July 2020. Participants completed the sociodemographic information questionnaire, the PROMIS social function short forms, the Functional Assessment of Cancer Therapy-Breast, the PROMIS emotional support short form and the PROMIS anxiety short form. Results Data were collected from a sample of 633 patients whose mean age was 48.1 years. The measures showed an absence of floor and ceiling effects. Regarding construct validity, the results of confirmatory factor analysis supported the original two-factor structure of the PROMIS social function short forms. In addition, the measures were found to have acceptable known-group validity, measurement invariance, and convergent and discriminate validity. Regarding reliability, the Cronbach’s α was high for all items (> 0.70). Conclusion The Chinese version of the PROMIS social function short forms was demonstrated to be a valid and reliable measure for the assessment of social function in Chinese patients with breast cancer. Additional psychometric evaluation is needed to draw firm conclusions.

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Abstract: The Malayalam translation of the FACT-B questionnaire was developed, tested and validated, and was found satisfactory in comparison to the source tool.

Cited by 38 publications

References 9 publications

Quality of Life in Early Breast Cancer Patients: A Prospective Observational Study Using the FACT-B Questionnaire

Quality of Life in Early Breast Cancer Patients: A Prospective Observational Study Using the FACT-B Questionnaire

Quality of life and its sociodemographic determinants in breast cancer patients

Psychometric evaluation of the PROMIS social function short forms in Chinese patients with breast cancer

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