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Habib, Muhammad J.; Asker, Ahmed F.

doi:10.1023/a:1015851719579

Cited by 10 publications

(3 citation statements)

References 2 publications

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“…Although stability of riboflavin has been studied in mixed parenteral nutrition solution [9], milk powders [10], antibiotic solutions [11] and mixtures of liposomes and riboflavin [12], limited data have been published on the short term stability of urinary riboflavin [1,2] and no data have been published on long term stability of urinary riboflavin. We now present our studies on the stability of urinary riboflavin during light exposure and long-term storage at 4 or −20 • C.…”

Section: Introductionmentioning

confidence: 99%

Determination of riboflavin by high-performance liquid chromatography with riboflavin-depleted urine as calibration and control matrix

Meng

Andrenyak

Moody

et al. 2005

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Determination of riboflavin by high-performance liquid chromatography with riboflavin-depleted urine as calibration and control matrix

Meng

Andrenyak

Moody

et al. 2005

Journal of Chromatography B

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“…The literature describes the synthesis and characteristics of stable complexes of MTZ with iron (in a molar ratio of 1:3), manganese, copper, cobalt, and nickel (1:2) [6]. In addition, the greater photostability of the drug in combination with sodium urate was demonstrated compared to free MTZ [7]. The use of the MTZ ester inclusion complex, as benzoate, together with β-cyclodextrin (in a 1:1.5 molar ratio) resulted in greater solubility, improved physical stability of the drug, and inhibition of the transformation of its anhydrous form into monohydrate, occurring in aqueous suspensions [8].…”

Section: Introductionmentioning

confidence: 99%

Stability of Metronidazole and Its Complexes with Silver(I) Salts under Various Stress Conditions

et al. 2021

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Metronidazole is a drug widely used in the prevention and treatment of bacterial infections. Due to its possibility of the formation of stable metal complexes, it was decided to broaden its activity spectrum by introducing the silver(I) coordination compounds i.e., [Ag(MTZ)2NO3] and [(Ag(MTZ)2)2]SO4, which have significant antibacterial properties. The paper presents a description of a new qualitative and quantitative analysis of metronidazole in bulk and possible pharmaceutical preparations by thin-layer chromatography with densitometric detection. Optimal separation conditions were selected, and the analytical procedure was validated according to the ICH guidelines. The obtained data indicate that the method is sufficiently sensitive, precise, and accurate. The stability of the metronidazole solutions obtained from tablets, pure metronidazole, and its silver(I) complexes was tested. The research was carried out in various environments, at different temperatures, in H2O2 solution, and during exposure to radiation (UV, sunlight). The greatest degradation was found in the alkaline environment and at higher temperatures. The silver(I) complexes exhibited relatively high stability under analyzed conditions that are higher than standard metronidazole solutions and tablets. The observations were confirmed by the kinetic and thermodynamic analysis. The described studies of new metronidazole silver(I) complexes increase the potential for their application in infections both in humans and animals.

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“…The removal of such pollutants are therefore of paramount importance. Several separation technologies, e.g., adsorption, photo-degradation, ozonation, and biological methods etc., have been suggested for the removal of nitroimidazoles from aqueous solutions [10][11][12][13][14][15][16][17][18][19][20][21][22]. However, the choice of the most suitable technology depends upon its cost-effectiveness for large-scale applications.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Synthesis of SiC Nanoparticles for the Efficient Adsorptive Removal of Nitroimidazole Antibiotics from Aqueous Solution

et al. 2017

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Abstract:Environmental pollution caused by the improper disposal of pharmaceuticals is a matter of global concern, and warrants immediate attention. Of particular concern is the aquatic contamination caused by the increasing use of antibiotics, which could give rise to superbugs. While researchers have mainly focused on improving the adsorption capacity of mostly activated carbon-based adsorbents, we have developed a non-conventional adsorbent (SiC nanoparticles) in the present work for the adsorptive removal of four different nitroimidazole antibiotics, namely metronidazole (MNZ), dimetridazole (DMZ), ronidazole (RNZ), and tinidazole (TNZ). In addition to the unique properties which are inherent to SiC, the present adsorbent not only possesses a high adsorption capacity, but also shows one of the highest adsorption rates; both of which are prerequisites for an efficient and cost-effective adsorption-based separation technology. Silicon carbide (SiC) nanoparticles, synthesized by a microwave-assisted method, were thoroughly characterized using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and the Brunauer-Emmett-Teller method. The adsorption isotherm data were accurately described by the Langmuir isotherm model. On the other hand, the adsorption kinetics, closely represented by the pseudo-second order kinetic model, were faster than most previously reported adsorbents. The reaction rate constants were 0.0089, 0.0079, 0.0072, and 0.0055 g/(mg min), for MNZ, DMZ, RNZ, and TNZ, respectively.

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Cited by 10 publications

References 2 publications

Determination of riboflavin by high-performance liquid chromatography with riboflavin-depleted urine as calibration and control matrix

Determination of riboflavin by high-performance liquid chromatography with riboflavin-depleted urine as calibration and control matrix

Stability of Metronidazole and Its Complexes with Silver(I) Salts under Various Stress Conditions

Microwave-Assisted Synthesis of SiC Nanoparticles for the Efficient Adsorptive Removal of Nitroimidazole Antibiotics from Aqueous Solution

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