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Zykov, M. P.; Romanovskii, V. N.; Wester, D. W.; Bartenev, S. A.; Korpusov, G.V.; Filyanin, A. T.; Бабаин, В. А.; Кодина, Г. Е.; Strelkov, S. A.; Erofeev, S P.; Firsin, N. G.

doi:10.1023/a:1012820811058

Cited by 15 publications

(8 citation statements)

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“…The threshold energies of 100 Mo(p,p7n) and 96 Zr(a,7n) reactions are respectively 56.4 and 54.9 MeV [13]. However, in case of proton-induced reactions on 100 Mo targets, the 99 Mo separation from 100 Mo is not possible by chemistry, which results to low-SA product, forcing the use of alternative generator systems, such as gel generators [18][19][20][21], nanocrystalline column matrix generators [22] and large centralized generator facilities [23]. A 99m Tc concentration technique has also been proposed for large elution volume from low-SA generators [24].…”

Section: Resultsmentioning

confidence: 99%

Experimental cross section evaluation for innovative 99Mo production via the (α,n) reaction on 96Zr target

Pupillo

Esposito

Gambaccini

et al. 2014

J Radioanal Nucl Chem

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The high-specific activity 99Mo accelerator-based production, via the (α,n) reaction on 96Zr-enriched target, has been investigated in the present work. The excitation function measurement has been performed in the energy range 8–34 MeV at the ARRONAX facility, using the well-known stacked foils technique on natural zirconium as target. A general good agreement in the cross section trend has been observed, once compared to former measurements. A different (i.e. higher) peak value and a shift of about 2 MeV towards larger energies have however been found. Assuming a fully enriched 96Zr target irradiated by an α-beam at suitable energy (E = 25 MeV), the 99Mo production yield has thus been estimated. At last the alternative production routes, based on the 96Zr(α,n)99Mo and 100Mo(p,x)99Mo/99mTc reactions, are compared

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Section: Resultsmentioning

confidence: 99%

Experimental cross section evaluation for innovative 99Mo production via the (α,n) reaction on 96Zr target

Pupillo

Esposito

Gambaccini

et al. 2014

J Radioanal Nucl Chem

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“…Assignment of the spectra was based on 1 H NMR, 13 C NMR, IR, and HR-MS experiments, as previously published methods [36]. [ 99m Tc]NaTcO 4 was obtained in a saline solution from a 99m Mo/ 99m Tc generator [45,46] supplied by the China Institute of Atomic Energy. The radioactivity of the samples was assessed by an HRS-1000 technetium analyzer and Wizard 2480 gamma counter.…”

Section: Methodsmentioning

confidence: 99%

Preparation and Bioevaluation of Novel 99mTc-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia

et al. 2021

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To develop novel 99mTc-labeled single-photon emission computed tomography (SPECT) radiotracers for imaging hypoxia, a novel HYNICNM ligand (6-hydrazinonicotinamide (HYNIC) 2-nitroimidazole derivative) was designed and synthesized. It was radiolabeled with technetium-99m using tricine/trisodium triphenylphosphine-3,3′,3′′-trisulfonate (TPPTS), tricine/sodium triphenylphosphine-3-monosulfonate (TPPMS) and tricine as co-ligands to obtain [99mTc]Tc-tricine-TPPTS-HYNICNM, [99mTc]Tc-tricine-TPPMS-HYNICNM, and [99mTc]Tc-(tricine)2-HYNICNM, respectively. The three technetium-99m complexes were radiolabeled in one step with a high yield (95%) and had good stability in saline and mouse serum. In vitro cellular uptake results showed that these complexes exhibited good hypoxic selectivity. The partition coefficient indicated that they were good hydrophilic complexes, and [99mTc]Tc-tricine-TPPTS-HYNICNM displayed the highest hydrophilicity (-3.02 ± 0.08). The biodistribution in mice bearing S180 tumors showed that [99mTc]Tc-tricine-TPPTS-HYNICNM exhibited higher tumor uptake (1.05 ± 0.27% IA/g); more rapid clearance from the liver, blood, muscle, and other non-target organs; and a higher tumor/non-target ratio, especially for the tumor/liver ratio (1.95), than [99mTc]Tc-tricine-TPPMS-HYNICNM and [99mTc]Tc-(tricine)2-HYNICNM. The results of single-photon emission computed tomography (SPECT) imaging studies of [99mTc]Tc-tricine-TPPTS-HYNICNM were in accordance with the biodistribution results, which suggested that [99mTc]Tc-tricine-TPPTS-HYNICNM is a promising agent for imaging tumor hypoxia.

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“…The main schemes of 99 Мо isolation are described as a review [3]. As a basis of a process for Mo isolation from 235 U fission products, we took the procedure developed at the Institute of Biophysics [4].…”

Section: Characteristics Of Irradiation Processmentioning

confidence: 99%

Production of fission 99Mo at the VVR-ts nuclear reactor in a closed-loop process with respect to U

et al. 2012

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Technological aspects of 99 Mo production from 235 U at the VVR-ts nuclear reactor are considered. The nuclear target design with which the formation of liquid and solid wastes is reduced to a minimum and the forced system for cooling of nuclear targets in experimental channels of the nuclear reactor are reported. Schemes of 99 Mo isolation from 235 U fission products and of 235 U regeneration after 99 Mo isolation are described. The 99 Mo and, correspondingly, 99m Tc produced from the regenerated 235 U fully meet the technical specification and pharmacopoeial monograph for sodium pertechnetate.

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Cited by 15 publications

References 0 publications

Experimental cross section evaluation for innovative 99Mo production via the (α,n) reaction on 96Zr target

Experimental cross section evaluation for innovative 99Mo production via the (α,n) reaction on 96Zr target

Preparation and Bioevaluation of Novel 99mTc-Labeled Complexes with a 2-Nitroimidazole HYNIC Derivative for Imaging Tumor Hypoxia

Production of fission 99Mo at the VVR-ts nuclear reactor in a closed-loop process with respect to U

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