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Gupta, Anoop K.; Maheshwari, Alok; Tresch, Donald D.; Thakur, Ranjan K.

doi:10.1023/a:1017963928016

Cited by 32 publications

(6 citation statements)

References 67 publications

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“…Importantly, these findings suggest that during aging the incidence of cardiac arrhythmias is greater in the atria than in the ventricles. This result is consistent with a reduction in the number of pacemaker cells in the SA node, atrial enlargement and increase in atrial fibrous and fatty tissue [6] , [16] . Atrial tissue in our aged rats was characterized by an elevated degree in collagen deposition which involves an electrical remodeling.…”

Section: Discussionsupporting

confidence: 86%

“…Based on these observations, we hypothesized that the aging process is associated with changes in the distal conducting system, leading to uncoordinated and delayed myocardial excitation and contraction. Impaired interaction between the distal conducting system and the ventricular myocardium might create a potential reentry substrate, which would alter electrical stability and contribute to a higher incidence of ventricular arrhythmias in the elderly population [16] , [17] .…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Aging on the Specialized Conducting System: A Telemetry ECG Study in Rats over a 6 Month Period

et al. 2014

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Advanced age alone appears to be a risk factor for increased susceptibility to cardiac arrhythmias. We previously observed in the aged rat heart that sinus rhythm ventricular activation is delayed and characterized by abnormal epicardial patterns although conduction velocity is normal. While these findings relate to an advanced stage of aging, it is not yet known when and how ventricular electrical impairment originates and which is the underlying substrate. To address these points, we performed continuous telemetry ECG recordings in freely moving rats over a six-month period to monitor ECG waveform changes, heart rate variability and the incidence of cardiac arrhythmias. At the end of the study, we performed in-vivo multiple lead epicardial recordings and histopathology of cardiac tissue. We found that the duration of ECG waves and intervals gradually increased and heart rate variability gradually decreased with age. Moreover, the incidence of cardiac arrhythmias gradually increased, with atrial arrhythmias exceeding ventricular arrhythmias. Epicardial multiple lead recordings confirmed abnormalities in ventricular activation patterns, likely attributable to distal conducting system dysfunctions. Microscopic analysis of aged heart specimens revealed multifocal connective tissue deposition and perinuclear myocytolysis in the atria. Our results demonstrate that aging gradually modifies the terminal part of the specialized cardiac conducting system, creating a substrate for increased arrhythmogenesis. These findings may open new therapeutic options in the management of cardiac arrhythmias in the elderly population.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

The Effect of Aging on the Specialized Conducting System: A Telemetry ECG Study in Rats over a 6 Month Period

et al. 2014

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“…When symptomatic bradycardia is related to extrinsic causes, removal of potentially reversible causes of the bradycardia is always the first approach to management 2-4). Severe symptomatic bradycardia has been observed during therapy with beta-blockers and non-DHP calcium channels antagonists 3-5).…”

Section: Discussionmentioning

confidence: 99%

“…Combined drug therapy, advanced age, a history of prior myocardial infarction, decreased systolic performance, and ventricular arrhythmia increase the risk of bradyarrhythmic complications associated with drug therapy 2)8)12). In a study of patients with high-degree AV block, a QRS width ≥120 ms was an independent predictor for the progression of a high-degree AV block after drug withdrawal 13).…”

Section: Discussionmentioning

confidence: 99%

Prognosis and Natural History of Drug-Related Bradycardia

et al. 2009

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Background and ObjectivesThe prognosis and natural history of bradycardia related to drugs such as beta-blockers and non-dihydropyridine calcium channel blockers are not well known.Subjects and MethodsWe retrospectively analyzed 38 consecutive patients (age 69±11, 21 women) with drug-related bradycardia (DRB) between March 2005 and September 2007. A drug-associated etiology for the bradycardia was established based on the medical history and patient response to drug discontinuation. The mean follow-up duration was 18±8 months.ResultsThe initial electrocardiogram (ECG) showed sinus bradycardia (heart rate ≤40/min) in 13 patients, sinus bradycardia with junctional escape beats in 18 patients, and third-degree atrioventricular (AV) block in seven patients. Drug discontinuation was followed by resolution of bradycardia in 60% of patients (n=23). Among them, five (17.8%) patients resumed taking the culprit medication after discharge and none developed bradycardia again. Bradycardia persisted in 10 (26.3%) patients despite drug withdrawal, and a permanent pacemaker was implanted in seven of them. Third-degree AV block, QRS width, and bradycardia requiring temporary transvenous pacing were significantly associated with the bradycardia caused by drugs.ConclusionBeta-blockers were the most common drugs associated with DRB. However, in one quarter of the cases the DRB was not associated with drugs; in these patients permanent pacemaker implantation should be considered.

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“…Aging is considered a risk factor for ventricular arrhythmia [ 67 , 68 ]. In addition, aging is also associated with an increase in the percentage of incidence of atrial fibrillation [ 60 , 69 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

Rice

Fannin

Gillette

et al. 2014

Journal of Aging Research

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Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging.

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Cited by 32 publications

References 67 publications

The Effect of Aging on the Specialized Conducting System: A Telemetry ECG Study in Rats over a 6 Month Period

The Effect of Aging on the Specialized Conducting System: A Telemetry ECG Study in Rats over a 6 Month Period

Prognosis and Natural History of Drug-Related Bradycardia

Efficacy of Female Rat Models in Translational Cardiovascular Aging Research

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